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Ventilator-Associated Pneumonia-Quantum Uncertainty in the ICU?
Andrew Conway Morris
May 21, 2018
More has been written about ventilator-associated pneumonia (VAP) than any other nosocomial infection, with more PubMed records than the next two most prevalent nosocomial infections combined. However, despite this monumental...
Epidemiology, etiology, and diagnosis of health care acquired pneumonia including ventilator-associated pneumonia in Nepal.
Sabina Dongol, Gyan Kayastha, Nhukesh Maharjan, Sarita Pyatha, Rajkumar K C, Louise Thwaites, Buddha Basnyat, Stephen Baker, Abhilasha Karkey
Nov 22, 2021
Epidemiologic data regarding health care acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) from Nepal are negligible. We conducted a prospective observational cohort study in the intensive care unit (ICU) of a...
16S pan-bacterial PCR can accurately identify patients with ventilator-associated pneumonia
A Conway Morris, N Gadsby, JP McKenna, TP Hellyer, P Dark, S Singh, TS Walsh, DF McAuley, K Templeton, AJ Simpson, R McMullan
Dec 13, 2016
Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia.
Thomas P Hellyer, Andrew Conway Morris, Daniel F McAuley, Timothy S Walsh, Niall H Anderson, Suveer Singh, Paul Dark, Alistair I Roy, Simon V Baudouin, Stephen E Wright, Gavin D Perkins, Kallirroi Kefala, Melinda Jeffels, Ronan McMullan, Cecilia M O'Kane, Craig Spencer, Shondipon Laha, Nicole Robin, Savita Gossain, Kate Gould, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Emma M Browne, James G MacFarlane, Sarah Wiscombe, John D Widdrington, Ian Dimmick, Ian F Laurenson, Frans Nauwelaers, A John Simpson
Jun 26, 2020
BACKGROUND: Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-acquired pneumonia (VAP). However, successful...
Pulmonary infections complicating ARDS.
Charles-Edouard Luyt, Lila Bouadma, Andrew Conway Morris, Jayesh A Dhanani, Marin Kollef, Jeffrey Lipman, Ignacio Martin-Loeches, Saad Nseir, Otavio T Ranzani, Antoine Roquilly, Matthieu Schmidt, Antoni Torres, Jean-François Timsit
Dec 02, 2020
Pulmonary infection is one of the main complications occurring in patients suffering from acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of lung immune defenses and microbiota may...
Effectiveness of biomarker-based exclusion of ventilator-acquired pneumonia to reduce antibiotic use (VAPrapid-2)
Thomas P Hellyer, Niall H Anderson, Jennie Parker, Paul Dark, Tina Van Den Broeck, Suveer Singh, Ronan McMullan, Ashley M Agus, Lydia M Emerson, Bronagh Blackwood, Savita Gossain, Tim S Walsh, Gavin D Perkins, Andrew Conway Morris, Daniel F McAuley, A John Simpson
Jul 18, 2018
BACKGROUND: Ventilator-acquired pneumonia (VAP) is a common reason for antimicrobial therapy in the intensive care unit (ICU). Biomarker-based diagnostics could improve antimicrobial stewardship through rapid exclusion of VAP....
Antibiotic stewardship biomarker randomised controlled trial Ventilator-acquired pneumonia Anti-Bacterial Agents Antimicrobial Stewardship Bacteria Biomarkers Bronchoalveolar Lavage Fluid Clinical Protocols Colony Count Microbial Hospital Mortality Humans Interleukin-1beta Interleukin-8 Length of Stay Organ Dysfunction Scores Patient Selection Pneumonia Bacterial Pneumonia Ventilator-Associated Predictive Value of Tests Prospective Studies Research Design Respiration Artificial Time Factors United Kingdom Unnecessary Procedures
Pulmonary Aspergillosis in Patients with Suspected Ventilator-associated Pneumonia in UK ICUs.
Laura Loughlin, Thomas P Hellyer, P Lewis White, Danny F McAuley, Andrew Conway Morris, Raquel B Posso, Malcolm D Richardson, David W Denning, A John Simpson, Ronan McMullan
Jul 06, 2020
Rationale:Aspergillus infection in patients with suspected ventilator-associated pneumonia remains uncharacterized because of the absence of a disease definition and limited access to sensitive diagnostic tests.Objectives: To...
Aspergillus Critical Care Diagnostic Tests prevalence Adult Age Distribution Aged Aspergillus Cohort Studies Comorbidity Critical Care Critical Illness DNA Fungal Female Follow-Up Studies Humans Intensive Care Units Male Middle Aged Pneumonia Ventilator-Associated Polymerase Chain Reaction prevalence Prospective Studies Pulmonary Aspergillosis Radiography Thoracic Risk Assessment Sex Distribution statistics Nonparametric United Kingdom
Ventilator-associated pneumonia in critically ill patients with COVID-19.
Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar, Nicholas M Brown, Stephen Baker, Vilas Navapurkar, Gordon Dougan, Josefin Bartholdson Scott, Andrew Conway Morris
Jan 04, 2021
Low-pathogenicity Mycoplasma spp. alter human monocyte and macrophage function and are highly prevalent among patients with ventilator-acquired pneumonia.
TJ Nolan, NJ Gadsby, TP Hellyer, KE Templeton, R McMullan, JP McKenna, J Rennie, CT Robb, TS Walsh, AG Rossi, A Conway Morris, AJ Simpson
Oct 21, 2016
Assisted Ventilation Bacterial Infection Cytokine Biology innate immunity Pneumonia Aged Bronchoalveolar Lavage Fluid Bronchoscopy Cross Infection Female Humans Intensive Care Units Lipopolysaccharides MACROPHAGES Male Middle Aged Monocytes Mycoplasma Phagocytosis Pneumonia Bacterial Pneumonia Ventilator-Associated Polymerase Chain Reaction prevalence United Kingdom
Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia.
Andrew Conway Morris, Kallirroi Kefala, Thomas S Wilkinson, Olga Lucia Moncayo-Nieto, Kevin Dhaliwal, Lesley Farrell, Timothy S Walsh, Simon J Mackenzie, David G Swann, Peter JD Andrews, Niall Anderson, John RW Govan, Ian F Laurenson, Hamish Reid, Donald J Davidson, Christopher Haslett, Jean-Michel Sallenave, A John Simpson
Jul 02, 2020
BACKGROUND: Ventilator-associated pneumonia (VAP) is the most commonly fatal nosocomial infection. Clinical diagnosis of VAP remains notoriously inaccurate. The hypothesis was tested that significantly augmented inflammatory...
Contrasting effects of linezolid on healthy and dysfunctional human neutrophils
Stephen J Evans, Aled EL Roberts, Andrew Conway Morris, A John Simpson, Llinos G Harris, Dietrich Mack, Rowena E Jenkins, Thomas S Wilkinson
Oct 12, 2020
Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of ventilator-associated pneumonia (VAP). Patients with VAP have poorly functioning neutrophils, related to increased levels of the complement fragment...