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Results: 10
A spatially resolved atlas of the human lung characterizes a gland-associated immune niche.
Elo Madissoon, Amanda J Oliver, Vitalii Kleshchevnikov, Anna Wilbrey-Clark, Krzysztof Polanski, Nathan Richoz, Ana Ribeiro Orsi, Lira Mamanova, Liam Bolt, Rasa Elmentaite, J Patrick Pett, Ni Huang, Chuan Xu, Peng He, Monika Dabrowska, Sophie Pritchard, Liz Tuck, Elena Prigmore, Shani Perera, Andrew Knights, Agnes Oszlanczi, Adam Hunter, Sara F Vieira, Minal Patel, Rik GH Lindeboom, Lia S Campos, Kazuhiko Matsuo, Takashi Nakayama, Masahiro Yoshida, Kaylee B Worlock, Marko Z Nikolić, Nikitas Georgakopoulos, Krishnaa T Mahbubani, Kourosh Saeb-Parsy, Omer Ali Bayraktar, Menna R Clatworthy, Oliver Stegle, Natsuhiko Kumasaka, Sarah A Teichmann, Kerstin B Meyer
Jan 13, 2023
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well defined. To (re)define tissue architecture of lung and airways, we profiled five...
Humoral and cellular immune responses to Lassa fever virus in Lassa fever survivors and their exposed contacts in Southern Nigeria.
Chinedu Ugwu, Testimony Olumade, Ebenezer Nwakpakpa, Venatius Onyia, Elizabeth Odeh, Rosemary Ogonna Duruiheoma, Chiedozie K Ojide, Matthew Afam Eke, Ifeanyi Emmanuel Nwafor, Nneka Chika-Igwenyi, Augustine M Abu, Benedict Azuogu, Nnennaya Ajayi, Emeka Ogah, Oluwafemi Ayodeji, Chukwuyem Abejegah, Nelson Adedosu, Nicholas Oyejide, Sylvester Abah, Abiola Omidele, Winifred Ingbian, Emmanuel Osoba, Philomena Eromon, Paul Oluniyi, Olusola Ogunsanya, Anise Happi, Patricia Otuh, Angalee Nadesalingam, George Carnell, Nina Krause, Ernest Aguinam, Rebecca Kinsley, Daniel Matthew L Storisteanu, Paul Tonks, Diana Nelson, Carley McAlister, Matthew Boisen, Robert Garry, Edward Wright, Nigel Temperton, Simon Frost, Jonathan Luke Heeney, Christian Happi
Dec 25, 2022
Biology and pathology of the uterine microenvironment and its natural killer cells
Abstract: Tissues are the new frontier of discoveries in immunology. Cells of the immune system are an integral part of tissue physiology and immunity. Determining how immune cells inhabit, housekeep, and defend gut, lung...
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway.
Brian J Willett, Joe Grove, Oscar A MacLean, Craig Wilkie, Giuditta De Lorenzo, Wilhelm Furnon, Diego Cantoni, Sam Scott, Nicola Logan, Shirin Ashraf, Maria Manali, Agnieszka Szemiel, Vanessa Cowton, Elen Vink, William T Harvey, Chris Davis, Patawee Asamaphan, Katherine Smollett, Lily Tong, Richard Orton, Joseph Hughes, Poppy Holland, Vanessa Silva, David J Pascall, Kathryn Puxty, Ana da Silva Filipe, Gonzalo Yebra, Sharif Shaaban, Matthew TG Holden, Rute Maria Pinto, Rory Gunson, Kate Templeton, Pablo R Murcia, Arvind H Patel, Paul Klenerman, Susanna Dunachie, PITCH Consortium, COVID-19 Genomics UK (COG-UK) Consortium, John Haughney, David L Robertson, Massimo Palmarini, Surajit Ray, Emma C Thomson
Aug 04, 2022
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T. R. Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R. Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A. Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R. Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E. Adolph
Apr 14, 2021
Abstract: The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by...
Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display
Tiziano Gaiotto, Walter Ramage, Christina Ball, Paul Risley, George W. Carnell, Nigel Temperton, Othmar G. Engelhardt, Simon E. Hufton
Feb 04, 2021
Abstract: Influenza H7N9 virus continues to cause infections in humans and represents a significant pandemic risk. During the most recent 5th epidemic wave in 2016/17 two distinct lineages with increased human infections and...
Immune dysregulation among students exposed to exam stress and its mitigation by mindfulness training
Lorinda Turner, Julieta Galante, Maris Vainre, Jan Stochl, Géraldine Dufour, Peter B. Jones
Apr 02, 2021
Abstract: Psychological distress persisting for weeks or more promotes pro-inflammatory immune dysregulation, a risk factor for a range of chronic diseases. We have recently shown that mindfulness training reduces distress among...
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2
Panagiota Vardaka, Teresa Lozano, Christopher Bot, Jonathan Ellery, Sarah K. Whiteside, Charlotte J. Imianowski, Stuart Farrow, Simon Walker, Hanneke Okkenhaug, Jie Yang, Klaus Okkenhaug, Paula Kuo, Rahul Roychoudhuri
Nov 03, 2020
Abstract: Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and...
Integrated genomics point to immune vulnerabilities in pleural mesothelioma
Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun, Spyridon Gennatas, Robert C. Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G. Nicholson, Sanjay Popat, Anne E. Willis, Marion MacFarlane, Mark Lathrop, Anne M. Bowcock, Miriam F. Moffatt, William O. C. M. Cookson
Sep 27, 2021
Immunological considerations and challenges for regenerative cellular therapies
Sandra Petrus-Reurer, Marco Romano, Sarah Howlett, Joanne Louise Jones, Giovanna Lombardi, Kourosh Saeb-Parsy
Jun 25, 2021
Abstract: The central goal of regenerative medicine is to replace damaged or diseased tissue with cells that integrate and function optimally. The capacity of pluripotent stem cells to produce unlimited numbers of differentiated...