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Results: 5
Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression.
Aleksandr Talishinsky, Jonathan Downar, Petra E Vértes, Jakob Seidlitz, Katharine Dunlop, Charles J Lynch, Heather Whalley, Andrew McIntosh, Fidel Vila-Rodriguez, Zafiris J Daskalakis, Daniel M Blumberger, Conor Liston
Sep 28, 2022
The neural substrates of depression may differ in men and women, but the underlying mechanisms are incompletely understood. Here, we show that depression is associated with sex-specific patterns of abnormal functional...
Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat
Laith Alexander, Christian M. Wood, Philip L. R. Gaskin, Stephen J. Sawiak, Tim D. Fryer, Young T. Hong, Lauren McIver, Hannah F. Clarke, Angela C. Roberts
Oct 28, 2021
Abstract: Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex...
Brain-behaviour modes of covariation in healthy and clinically depressed young people
Agoston Mihalik, Fabio S. Ferreira, Maria J. Rosa, Michael Moutoussis, Gabriel Ziegler, Joao M. Monteiro, Liana Portugal, Rick A. Adams, Rafael Romero-Garcia, Petra E. Vértes, Manfred G. Kitzbichler, František Váša, Matilde M. Vaghi, Edward T. Bullmore, Peter Fonagy, Ian M. Goodyer, Peter B. Jones, Raymond Dolan, Janaina Mourão-Miranda, Tobias Hauser, Sharon Neufeld, Michelle St Clair, Kirstie Whitaker, Becky Inkster, Gita Prabhu, Cinly Ooi, Umar Toseeb, Barry Widmer, Junaid Bhatti, Laura Villis, Ayesha Alrumaithi, Sarah Birt, Aislinn Bowler, Kalia Cleridou, Hina Dadabhoy, Emma Davies, Ashlyn Firkins, Sian Granville, Elizabeth Harding, Alexandra Hopkins, Daniel Isaacs, Janchai King, Danae Kokorikou, Christina Maurice, Cleo McIntosh, Jessica Memarzia, Harriet Mills, Ciara O’Donnell, Sara Pantaleone, Jenny Scott, Pasco Fearon, John Suckling, Anne-Laura van Harmelen, Rogier Kievit
Aug 07, 2020
Abstract: Understanding how variations in dimensions of psychometrics, IQ and demographics relate to changes in brain connectivity during the critical developmental period of adolescence and early adulthood is a major challenge....
Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat
Laith Alexander, Christian M. Wood, Philip L. R. Gaskin, Stephen J. Sawiak, Tim D. Fryer, Young T. Hong, Lauren McIver, Hannah F. Clarke, Angela C. Roberts
Oct 26, 2020
Abstract: Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex...
Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures
Jiao Li, Jakob Seidlitz, John Suckling, Feiyang Fan, Gong-Jun Ji, Yao Meng, Siqi Yang, Kai Wang, Jiang Qiu, Huafu Chen, Wei Liao
Mar 12, 2021
Abstract: Major depressive disorder (MDD) has been shown to be associated with structural abnormalities in a variety of spatially diverse brain regions. However, the correlation between brain structural changes in MDD and gene...