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Developmental programming of offspring adipose tissue biology and obesity risk
Abstract: Obesity is reaching epidemic proportions and imposes major negative health crises and an economic burden in both high and low income countries. The multifaceted nature of obesity represents a major health challenge...
Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance.
Simon T Bond, Emily J King, Darren C Henstridge, Adrian Tran, Sarah C Moody, Christine Yang, Yingying Liu, Natalie A Mellett, Artika P Nath, Michael Inouye, Elizabeth J Tarling, Thomas Q de Aguiar Vallim, Peter J Meikle, Anna C Calkin, Brian G Drew
Jan 04, 2021
The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (Trim28), a gene...