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Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.
Jingxu Guo, Bin Liu, Midory Thorikay, Minmin Yu, Xiaoyan Li, Zhen Tong, Richard M Salmon, Randy Read, Peter Ten Dijke, Nicholas Morrell, Wei Li
May 09, 2022
Heterozygous mutations in BMPR2 (bone morphogenetic protein (BMP) receptor type II) cause pulmonary arterial hypertension. BMPRII is a receptor for over 15 BMP ligands, but why BMPR2 mutations cause lung-specific pathology is...