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In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
Xiaodong Shi, Muyuan Chen, Zhili Yu, James M. Bell, Hans Wang, Isaac Forrester, Heather Villarreal, Joanita Jakana, Dijun Du, Ben F. Luisi, Steven J. Ludtke, Zhao Wang
Jun 15, 2020
Abstract: Multidrug efflux pumps actively expel a wide range of toxic substrates from the cell and play a major role in intrinsic and acquired drug resistance. In Gram-negative bacteria, these pumps form tripartite assemblies...