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A RAC-GEF network critical for early intestinal tumourigenesis
K. A. Pickering, K. Gilroy, J. W. Cassidy, S. K. Fey, A. K. Najumudeen, L. B. Zeiger, D. F. Vincent, D. M. Gay, J. Johansson, R. P. Fordham, B. Miller, W. Clark, A. Hedley, E. B. Unal, C. Kiel, E. McGhee, L. M. Machesky, C. Nixon, A. E. Johnsson, M. Bain, D. Strathdee, S. R. van Hoof, J. P. Medema, K. I. Anderson, S. M. Brachmann, V. M. Stucke, A. Malliri, M. Drysdale, M. Turner, L. Serrano, K. Myant, A. D. Campbell, O. J. Sansom
Jan 04, 2021
Abstract: RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon...