Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
Roy Rabbie,
Naser Ansari-Pour,
Oliver Cast,
Doreen Lau,
Francis Scott,
Sarah J. Welsh,
Christine Parkinson,
Leila Khoja,
Luiza Moore,
Mark Tullett,
Kim Wong,
Ingrid Ferreira,
Julia M. Martínez Gómez,
Mitchell Levesque,
Ferdia A. Gallagher,
Alejandro Jiménez-Sánchez,
Laura Riva,
Martin L. Miller,
Kieren Allinson,
Peter J. Campbell,
Pippa Corrie,
David C. Wedge,
David J. Adams
Aug 27, 2020
Abstract: Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma metastases...