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Results: 7
Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
Hafsa Munir, James O. Jones, Tobias Janowitz, Markus Hoffmann, Maximilien Euler, Carla P. Martins, Sarah J. Welsh, Jacqueline D. Shields
Jan 29, 2021
Abstract: Tumors consist of cancer cells and a network of non-cancerous stroma. Cancer-associated fibroblasts (CAF) are known to support tumorigenesis, and are emerging as immune modulators. Neutrophils release histone-bound...
IDO1 + Paneth cells promote immune escape of colorectal cancer
Sandra Pflügler, Jasmin Svinka, Irene Scharf, Ilija Crncec, Martin Filipits, Pornpimol Charoentong, Markus Tschurtschenthaler, Lukas Kenner, Monira Awad, Judith Stift, Marina Schernthanner, Romana Bischl, Dietmar Herndler-Brandstetter, Elisabeth Glitzner, Herwig P. Moll, Emilio Casanova, Gerald Timelthaler, Maria Sibilia, Michael Gnant, Sigurd Lax, Josef Thaler, Mathias Müller, Birgit Strobl, Thomas Mohr, Arthur Kaser, Zlatko Trajanoski, Gerwin Heller, Robert Eferl
Feb 18, 2021
Abstract: Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune...
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 28, 2021
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
Mohamed Amgad, Elisabeth Specht Stovgaard, Eva Balslev, Jeppe Thagaard, Weijie Chen, Sarah Dudgeon, Ashish Sharma, Jennifer K. Kerner, Carsten Denkert, Yinyin Yuan, Khalid AbdulJabbar, Stephan Wienert, Peter Savas, Leonie Voorwerk, Andrew H. Beck, Anant Madabhushi, Johan Hartman, Manu M. Sebastian, Hugo M. Horlings, Jan Hudeček, Francesco Ciompi, David A. Moore, Rajendra Singh, Elvire Roblin, Marcelo Luiz Balancin, Marie-Christine Mathieu, Jochen K. Lennerz, Pawan Kirtani, I-Chun Chen, Jeremy P. Braybrooke, Giancarlo Pruneri, Sandra Demaria, Sylvia Adams, Stuart J. Schnitt, Sunil R. Lakhani, Federico Rojo, Laura Comerma, Sunil S. Badve, Mehrnoush Khojasteh, W. Fraser Symmans, Christos Sotiriou, Paula Gonzalez-Ericsson, Katherine L. Pogue-Geile, Rim S. Kim, David L. Rimm, Giuseppe Viale, Stephen M. Hewitt, John M. S. Bartlett, Frédérique Penault-Llorca, Shom Goel, Huang-Chun Lien, Sibylle Loibl, Zuzana Kos, Sherene Loi, Matthew G. Hanna, Stefan Michiels, Marleen Kok, Torsten O. Nielsen, Alexander J. Lazar, Zsuzsanna Bago-Horvath, Loes F. S. Kooreman, Jeroen A. W. M. van der Laak, Joel Saltz, Brandon D. Gallas, Uday Kurkure, Michael Barnes, Roberto Salgado, Lee A. D. Cooper, Aini Hyytiäinen, Akira I. Hida, Alastair Thompson, Alex Lefevre, Allen Gown, Amy Lo, Anna Sapino, Andre Moreira, Andrea Richardson, Andrea Vingiani, Andrew M. Bellizzi, Andrew Tutt, Angel Guerrero-Zotano, Anita Grigoriadis, Anna Ehinger, Anna C. Garrido-Castro, Anne Vincent-Salomon, Anne-Vibeke Laenkholm, Ashley Cimino-Mathews, Ashok Srinivasan, Balazs Acs, Baljit Singh, Benjamin Calhoun, Benjamin Haibe-Kans, Benjamin Solomon, Bibhusal Thapa, Brad H. Nelson, Carlos Castaneda, Carmen Ballesteroes-Merino, Carmen Criscitiello, Carolien Boeckx, Cecile Colpaert, Cecily Quinn, Chakra S. Chennubhotla, Charles Swanton, Cinzia Solinas, Crispin Hiley, Damien Drubay, Daniel Bethmann, Deborah A. Dillon, Denis Larsimont, Dhanusha Sabanathan, Dieter Peeters, Dimitrios Zardavas, Doris Höflmayer, Douglas B. Johnson, E. Aubrey Thompson, Edi Brogi, Edith Perez, Ehab A. ElGabry, Elizabeth F. Blackley, Emily Reisenbichler, Enrique Bellolio, Ewa Chmielik, Fabien Gaire, Fabrice Andre, Fang-I Lu, Farid Azmoudeh-Ardalan, Forbius Tina Gruosso, Franklin Peale, Fred R. Hirsch, Frederick Klaushen, Gabriela Acosta-Haab, Gelareh Farshid, Gert van den Eynden, Giuseppe Curigliano, Giuseppe Floris, Glenn Broeckx, Harmut Koeppen, Harry R. Haynes, Heather McArthur, Heikki Joensuu, Helena Olofsson, Ian Cree, Iris Nederlof, Isabel Frahm, Iva Brcic, Jack Chan, Jacqueline A. Hall, James Ziai, Jane Brock, Jelle Wesseling, Jennifer Giltnane, Jerome Lemonnier, Jiping Zha, Joana M. Ribeiro, Jodi M. Carter, Johannes Hainfellner, John Le Quesne, Jonathan W. Juco, Jorge Reis-Filho, Jose van den Berg, Joselyn Sanchez, Joseph Sparano, Joël Cucherousset, Juan Carlos Araya, Julien Adam, Justin M. Balko, Kai Saeger, Kalliopi Siziopikou, Karen Willard-Gallo, Karolina Sikorska, Karsten Weber, Keith E. Steele, Kenneth Emancipator, Khalid El Bairi, Kim R. M. Blenman, Kimberly H. Allison, Koen K. van de Vijver, Konstanty Korski, Lajos Pusztai, Laurence Buisseret, Leming Shi, Liu Shi-wei, Luciana Molinero, M. Valeria Estrada, Maartje van Seijen, Magali Lacroix-Triki, Maggie C. U. Cheang, Maise al Bakir, Marc van de Vijver, Maria Vittoria Dieci, Marlon C. Rebelatto, Martine Piccart, Matthew P. Goetz, Matthias Preusser, Melinda E. Sanders, Meredith M. Regan, Michael Christie, Michael Misialek, Michail Ignatiadis, Michiel de Maaker, Mieke van Bockstal, Miluska Castillo, Nadia Harbeck, Nadine Tung, Nele Laudus, Nicolas Sirtaine, Nicole Burchardi, Nils Ternes, Nina Radosevic-Robin, Oleg Gluz, Oliver Grimm, Paolo Nuciforo, Paul Jank, Petar Jelinic, Peter H. Watson, Prudence A. Francis, Prudence A. Russell, Robert H. Pierce, Robert Hills, Roberto Leon-Ferre, Roland de Wind, Ruohong Shui, Sabine Declercq, Sam Leung, Sami Tabbarah, Sandra C. Souza, Sandra O’Toole, Sandra Swain, Scooter Willis, Scott Ely, Seong- Rim Kim, Shahinaz Bedri, Sheeba Irshad, Shi-Wei Liu, Shona Hendry, Simonetta Bianchi, Sofia Bragança, Soonmyung Paik, Stephen B. Fox, Stephen J. Luen, Stephen Naber, Sua Luz, Susan Fineberg, Teresa Soler, Thomas Gevaert, Timothy d’Alfons, Tom John, Tomohagu Sugie, Veerle Bossuyt, Venkata Manem, Vincente Peg Cámaea, Weida Tong, Wentao Yang, William T. Tran, Yihong Wang, Yves Allory, Zaheed Husain
Feb 12, 2021
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy.
Marcel P Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C Stinchcombe, Michal A Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S Thommen, Gillian M Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Feb 02, 2023
Tumors induce de novo steroid biosynthesis in T cells to evade immunity
Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Jul 17, 2020
Abstract: Tumors subvert immune cell function to evade immune responses, yet the complex mechanisms driving immune evasion remain poorly understood. Here we show that tumors induce de novo steroidogenesis in T lymphocytes to...
IDO1 + Paneth cells promote immune escape of colorectal cancer
Sandra Pflügler, Jasmin Svinka, Irene Scharf, Ilija Crncec, Martin Filipits, Pornpimol Charoentong, Markus Tschurtschenthaler, Lukas Kenner, Monira Awad, Judith Stift, Marina Schernthanner, Romana Bischl, Dietmar Herndler-Brandstetter, Elisabeth Glitzner, Herwig P. Moll, Emilio Casanova, Gerald Timelthaler, Maria Sibilia, Michael Gnant, Sigurd Lax, Josef Thaler, Mathias Müller, Birgit Strobl, Thomas Mohr, Arthur Kaser, Zlatko Trajanoski, Gerwin Heller, Robert Eferl
May 22, 2021
Abstract: Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune...