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Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture
Abstract Tailoring of the activity and specificity of proteases is critical for their utility across industrial, medical and research purposes. However, engineering or evolving protease catalysts...
Philipp Knyphausen, Mariana Rangel Pereira, Paul Brear, Marko Hyvönen, Lutz Jermutus, Florian Hollfelder
Feb 11, 2023
UMI-linked consensus sequencing enables phylogenetic analysis of directed evolution
Paul Jannis Zurek, Philipp Knyphausen, Katharina Neufeld, Ahir Pushpanath, Florian Hollfelder
Nov 26, 2020
Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Jiahui Tao, Michael F. Jobling, Shyra J. Gardai, Carlos W. Bertoncini, Nunilo Cremades, Michael Bova, Stephen Ballaron, Xiao-Hua Chen, Wenxian Mao, Phuong Nguyen, Mariano C. Tabios, Mitali A. Tambe, Jean-Christophe Rochet, Hans-Dieter Junker, Daniel Schwizer, Renate Sekul, Inge Ott, John P. Anderson, Balazs Szoke, Wherly Hoffman, John Christodoulou, Ted Yednock, David A. Agard, Dale Schenk, Lisa McConlogue
Nov 17, 2020
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age
Sarah E. Harris, Simon R. Cox, Steven Bell, Riccardo E. Marioni, Bram P. Prins, Alison Pattie, Janie Corley, Susana Muñoz Maniega, Maria Valdés Hernández, Zoe Morris, Sally John, Paola G. Bronson, Elliot M. Tucker-Drob, John M. Starr, Mark E. Bastin, Joanna M. Wardlaw, Adam S. Butterworth, Ian J. Deary
Feb 09, 2021