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Results: 1071
Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias.
Eleanor King, John Tiernan O'Brien, Paul Donaghy, Christopher Morris, Nicola Barnett, Kirsty Olsen, Carmen Martin-Ruiz, John-Paul Taylor, Alan J Thomas
Jan 29, 2018
Aged Aged 80 and over Alzheimer Disease C-Reactive Protein Case-Control Studies Cognitive Dysfunction Cytokines Female Humans Inflammation Interferon-gamma Interleukin-10 Interleukin-12 Interleukin-13 Interleukin-1beta Interleukin-2 Interleukin-4 Interleukin-6 Interleukin-8 Lewy Body Disease Male Prodromal Symptoms Tumor Necrosis Factor-alpha
Critical Thresholds of Intracranial Pressure-Derived Continuous Cerebrovascular Reactivity Indices for Outcome Prediction in Noncraniectomized Patients with Traumatic Brain Injury.
Frederick A Zeiler, Joseph Donnelly, Peter Smielewski, David K Menon, Peter J Hutchinson, Marek Czosnyka
Feb 19, 2018
The aim of the study was to compare intracranial pressure (ICP)-derived cerebrovascular reactivity indices in their ability to predict six-month outcome, and to determine/compare critical thresholds related to outcome for each...
How does the femoral cortex depend on bone shape? A methodology for the joint analysis of surface texture and shape.
In humans, there is clear evidence of an association between hip fracture risk and femoral neck bone mineral density, and some evidence of an association between fracture risk and the shape of the proximal femur. Here, we...
Shape Spatial normalization Statistical parametric mapping Textured surfaces Adult Aged Aged 80 and over Algorithms Anatomic Landmarks Computer Simulation Female Femur Hip Fractures Humans Organ Size Radiographic Image Interpretation Computer-Assisted Risk Factors Surface Properties Tomography X-Ray Computed
Clinical prevalence of Lewy body dementia.
Joseph PM Kane, Ajenthan Surendranathan, Allison Bentley, Sally AH Barker, John-Paul Taylor, Alan J Thomas, Louise M Allan, Richard J McNally, Peter W James, Ian G McKeith, David J Burn, John O'Brien
Apr 05, 2018
Background: The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and...
Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE)
Steven Bell, Michael Sweeting, Anna Ramond, Ryan Chung, Stephen Kaptoge, Matthew Walker, Thomas Bolton, Jennifer Sambrook, Carmel Moore, Amy McMahon, Sarah Fahle, Donna Cullen, Susan Mehenny, Angela M Wood, Jane Armitage, Willem H Ouwehand, Gail Miflin, David J Roberts, John Danesh, Emanuele Di Angelantonio, COMPARE Study Group
Jan 04, 2021
OBJECTIVE: To compare four haemoglobin measurement methods in whole blood donors. BACKGROUND: To safeguard donors, blood services measure haemoglobin concentration in advance of each donation. NHS Blood and Transplant's (NHSBT)...
HemoCue gravimetry haemoglobin screening inappropriate bleeding inappropriate deferral non-invasive haemoglobin measurement whole blood donor Adolescent Adult Aged Aged 80 and over Anemia Biomarkers Blood Donors Cross-Over Studies Donor Selection Female Hemoglobinometry Hemoglobins Humans Male Middle Aged Reference Standards Sensitivity and Specificity Spectrophotometry Young Adult
Fulminant corticobasal degeneration
Helen Ling, Ellen Gelpi, Karen Davey, Zane Jaunmuktane, Kin Y Mok, Edwin Jabbari, Roberto Simone, Lea R'Bibo, Sebastian Brandner, Matthew J Ellis, Johannes Attems, David Mann, Glenda M Halliday, S Al-Sarraj, J Hedreen, James W Ironside, Gabor G Kovacs, E Kovari, S Love, Jean Paul G Vonsattel, Kieren SJ Allinson, Daniela Hansen, Teisha Bradshaw, Núria Setó-Salvia, Selina Wray, Rohan de Silva, Huw R Morris, Thomas T Warner, John Hardy, Janice L Holton, Tamas Revesz
Jan 15, 2021
Corticobasal degeneration typically progresses gradually over 5-7 years from onset till death. Fulminant corticobasal degeneration cases with a rapidly progressive course were rarely reported (RP-CBD). This study aimed to...
A Highly Tailored Text and Voice Messaging Intervention to Improve Medication Adherence in Patients With Either or Both Hypertension and Type 2 Diabetes in a UK Primary Care Setting
Aikaterini Kassavou, Venus Mirzaei, James Brimicombe, Simon Edwards, Efthalia Massou, A Toby Prevost, Simon Griffin, Stephen Sutton
Aug 03, 2020
BACKGROUND: The efficacy of a highly tailored digital intervention to support medication adherence and feasibility to support clinical effectiveness as an adjunct to the primary care setting has not been evaluated. OBJECTIVE...
Hypertension interactive voice response Medication Adherence Text Messaging Type 2 diabetes Adolescent Adult Aged Aged 80 and over Diabetes mellitus Type 2 Feasibility Studies Female Humans Hypertension Male Medication Adherence Middle Aged Quality of life Text Messaging Treatment Outcome United Kingdom Young Adult
Comparative effectiveness of cognitive therapies delivered face-to-face or over the telephone
Geoffrey C Hammond, Tim J Croudace, Muralikrishnan Radhakrishnan, Louise Lafortune, Alison Watson, Fiona McMillan-Shields, Peter B Jones
Aug 05, 2020
OBJECTIVES: To compare the clinical and cost-effectiveness of face-to-face (FTF) with over-the-telephone (OTT) delivery of low intensity cognitive behavioural therapy. DESIGN: Observational study following SROBE guidelines....
Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia
RJ Haidry, MA Butt, JM Dunn, A Gupta, G Lipman, HL Smart, P Bhandari, L Smith, R Willert, G Fullarton, M di Pietro, C Gordon, I Penman, H Barr, P Patel, N Kapoor, J Hoare, R Narayanasamy, Y Ang, A Veitch, K Ragunath, M Novelli, LB Lovat, UK RFA Registry
Aug 20, 2020
BACKGROUND: Barrett's oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by...
BARRETT'S OESOPHAGUS ENDOSCOPIC PROCEDURES OESOPHAGEAL CANCER Adenocarcinoma Adult Aged Aged 80 and over Barrett Esophagus Catheter Ablation Disease Progression Esophageal Neoplasms Esophagoscopy Female Follow-Up Studies Humans Male Middle Aged Precancerous Conditions Prospective Studies Registries Time Factors Treatment Outcome United Kingdom
How does uncertainty shape patient experience in advanced illness? A secondary analysis of qualitative data.
Simon Noah Etkind, Katherine Bristowe, Katharine Bailey, Lucy Ellen Selman, Fliss Em Murtagh
Nov 26, 2020
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group, Peter Horby, Marion Mafham, Louise Linsell, Jennifer L Bell, Natalie Staplin, Jonathan R Emberson, Martin Wiselka, Andrew Ustianowski, Einas Elmahi, Benjamin Prudon, Tony Whitehouse, Timothy Felton, John Williams, Jakki Faccenda, Jonathan Underwood, J Kenneth Baillie, Lucy C Chappell, Saul N Faust, Thomas Jaki, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Kathryn Rowan, Joel Tarning, James A Watson, Nicholas J White, Edmund Juszczak, Richard Haynes, Martin J Landray
Dec 17, 2020
BACKGROUND: Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from uncontrolled studies and small, randomized trials. METHODS...
What influenced people with chronic or refractory breathlessness and advanced disease to take part and remain in a drug trial? A qualitative study.
BACKGROUND: Recruitment and retention in clinical trials remains an important challenge, particularly in the context of advanced disease. It is important to understand what affects retention to improve trial quality, minimise...
breathlessness Palliative Care person-centred care Qualitative randomised controlled trial Recruitment Retention Aged Aged 80 and over Chronic Disease Double-Blind Method Dyspnea Feasibility Studies Female Heart Failure Humans Lung Diseases Interstitial Male Middle Aged motivation Neoplasms Patient Participation Pulmonary Disease Chronic Obstructive qualitative research Quality of life Severity of Illness Index Surveys and Questionnaires United Kingdom
How and to what extent can pensions facilitate increased use of health services by older people
Shanquan Chen, Xi Chen, Stephen Law, Henry Lucas, Shenlan Tang, Qian Long, Lei Xue, Zheng Wang
Nov 09, 2020
Occupational Animal Contact in Southern and Central Vietnam.
Nguyen Thi Kha Tu, Ngo Tri Tue, Olli Vapalahti, Anna-Maija K Virtala, Le Van Tan, Maia A Rabaa, Juan Carrique-Mas, Guy E Thwaites, Stephen Baker, VIZIONS consortium
Nov 12, 2020
Despite the global zoonotic disease burden, the underlying exposures that drive zoonotic disease emergence are not understood. Here, we aimed to assess exposures to potential sources of zoonotic disease and investigate the...
Animal health workers cohort Emerging infections Exposure risk Slaughterers Vietnam zoonosis Abattoirs Adolescent Adult Aged Aged 80 and over Animals Cross-Sectional Studies Farmers Female Humans Male Meat Products Middle Aged occupational exposure Risk Assessment Socioeconomic Factors Surveys and Questionnaires Vietnam Young Adult Zoonoses
The implications of the gender-based prohibitions relating to human germline genome editing in the Human Fertilisation and Embryology Act.
Amarpreet Kaur
Nov 16, 2020
Assisted Reproductive Technologies Gender recognition certificates Germline genome editing Legislation transgender Uterine Transplants Adolescent Adult Aged Aged 80 and over embryology Female Gender Identity Gene Editing Germ Cells Humans Male Middle Aged Surveys and Questionnaires Transgender Persons Young Adult
The use of commercial computerised cognitive games in older adults
Brain training programs are currently one effective solution to prevent cognitive decline in healthy aging. We conducted a meta-analysis of randomized controlled trials assessing the use of commercially available computerised...
Cortical thickness mapping to identify focal osteoporosis in patients with hip fracture.
Kenneth ES Poole, Graham M Treece, Paul M Mayhew, Jan Vaculík, Pavel Dungl, Martin Horák, Jan J Štěpán, Andrew H Gee
Oct 15, 2020
BACKGROUND: Individuals with osteoporosis are predisposed to hip fracture during trips, stumbles or falls, but half of all hip fractures occur in those without generalised osteoporosis. By analysing ordinary clinical CT scans...
The Relationship Between Cognitive Performance Using Tests Assessing a Range of Cognitive Domains and Future Dementia Diagnosis in a British Cohort
Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12.
Netta Mäkinen, Mervi Aavikko, Tuomas Heikkinen, Minna Taipale, Jussi Taipale, Riitta Koivisto-Korander, Ralf Bützow, Pia Vahteristo
Jan 03, 2020
Uterine leiomyosarcomas (ULMSs) are aggressive smooth muscle tumors associated with poor clinical outcome. Despite previous cytogenetic and molecular studies, their molecular background has remained elusive. To examine somatic...
Adaptor Proteins Signal Transducing Aged Aged 80 and over Co-Repressor Proteins DNA Helicases Exome Female Gene Expression Regulation Neoplastic High-Throughput Nucleotide Sequencing Humans Leiomyosarcoma Mediator Complex Middle Aged Molecular Chaperones Mutation Rate Nuclear Proteins Telomere Homeostasis Tumor Suppressor Protein p53 Uterine Neoplasms X-linked Nuclear Protein
A critical appraisal of Monro's erroneous description of the cerebral interventricular foramina
Anatomic connections between the cerebral lateral and third ventricles have been mischaracterized since Monro's original erroneous description of his eponymous foramina (FoMs) as being only one T-shaped passage. Accurate...
Evaluation of universal immunohistochemical screening of sebaceous neoplasms in a service setting.
BACKGROUND: Muir-Torre syndrome (MTS) is a subtype of Lynch syndrome, which encompasses the combination of sebaceous skin tumours or keratoacanthomas and internal malignancy, due to mutations in DNA mismatch repair genes....
The AMBER care bundle for hospital inpatients with uncertain recovery nearing the end of life
Jonathan Koffman, Emel Yorganci, Fliss Murtagh, Deokhee Yi, Wei Gao, Stephen Barclay, Andrew Pickles, Irene Higginson, Halle Johnson, Rebecca Wilson, Sylvia Bailey, Colleen Ewart, Catherine Evans
Oct 22, 2019
BACKGROUND: Patients admitted to hospital with a terminal illness and uncertain recovery often receive inconsistent care and do not have the opportunity to die in their preferred place of death. Previous end-of-life care...
clinical uncertainty complex intervention end of life care FEASIBILITY CLUSTER RCT mixed methods outcomes Palliative Care Aged Aged 80 and over Cluster Analysis England Feasibility Studies Female Focus Groups Hospitalization Humans Inpatients Interviews as Topic Male Middle Aged Patient Care Bundles qualitative research Terminal Care uncertainty
Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.
Vincent CT Mok, Sarah Pendlebury, Adrian Wong, Suvarna Alladi, Lisa Au, Philip M Bath, Geert Jan Biessels, Christopher Chen, Charlotte Cordonnier, Martin Dichgans, Jacqueline Dominguez, Philip B Gorelick, SangYun Kim, Timothy Kwok, Steven M Greenberg, Jianping Jia, Rajesh Kalaria, Miia Kivipelto, Kandiah Naegandran, Linda CW Lam, Bonnie Yin Ka Lam, Allen TC Lee, Hugh S Markus, John O'Brien, Ming-Chyi Pai, Leonardo Pantoni, Perminder Sachdev, Ingmar Skoog, Eric E Smith, Velandai Srikanth, Guk-Hee Suh, Joanna Wardlaw, Ho Ko, Sandra E Black, Philip Scheltens
Jun 18, 2020
We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health-care settings...
Cardiac Energetics in Patients With Aortic Stenosis and Preserved Versus Reduced Ejection Fraction.
Mark A Peterzan, William T Clarke, Craig A Lygate, Hannah A Lake, Justin Yc Lau, Jack J Miller, Errin Johnson, Jennifer J Rayner, Moritz J Hundertmark, Rana Sayeed, Mario Petrou, George Krasopoulos, Vivek Srivastava, Stefan Neubauer, Christopher T Rodgers, Oliver J Rider
Jun 30, 2020
aortic valve stenosis creatine kinase Heart Failure Magnetic Resonance Spectroscopy metabolism Adenosine Triphosphate Adult Aged Aged 80 and over aortic valve stenosis Biomarkers creatine kinase Energy Metabolism Female Humans Magnetic Resonance Spectroscopy Male Middle Aged Prospective Studies Stroke Volume Ventricular Dysfunction Left Ventricular Function Left
Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward)
Adrian Murray Brunt, Joanne S Haviland, Duncan A Wheatley, Mark A Sydenham, Abdulla Alhasso, David J Bloomfield, Charlie Chan, Mark Churn, Susan Cleator, Charlotte E Coles, Andrew Goodman, Adrian Harnett, Penelope Hopwood, Anna M Kirby, Cliona C Kirwan, Carolyn Morris, Zohal Nabi, Elinor Sawyer, Navita Somaiah, Liba Stones, Isabel Syndikus, Judith M Bliss, John R Yarnold, FAST-Forward Trial Management Group
May 26, 2020
BACKGROUND: We aimed to identify a five-fraction schedule of adjuvant radiotherapy (radiation therapy) delivered in 1 week that is non-inferior in terms of local cancer control and is as safe as an international standard...
Adult Aged Aged 80 and over Breast Neoplasms Female Follow-Up Studies Humans Kaplan-Meier Estimate Mastectomy Middle Aged Neoplasm Grading Neoplasm Metastasis Neoplasm Recurrence Local Neoplasm Staging Radiation Dose Hypofractionation Radiation Injuries Radiotherapy Adjuvant Risk Assessment Treatment Outcome United Kingdom
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