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Plasmodium falciparum, the parasite that causes the deadliest form of malaria, has evolved multiple proteins known as invasion ligands that bind to specific erythrocyte receptors to facilitate invasion of human erythrocytes. The...

Plasmodium falciparum cultured erythrocyte glycophorin host cell invasion Malaria red blood cells transcriptional variation Computational Biology Erythrocytes Glycophorins Humans Ligands Plasmodium falciparum Protein Binding Proteomics Receptors Cell Surface

Animals Biological Evolution Humans Immunity Innate Life Cycle Stages Models Molecular Primates Protozoan Proteins Receptors Cell Surface Trypanosoma brucei brucei Trypanosomiasis African Tsetse Flies

Antigens Protozoan Erythrocytes host-parasite interactions Humans Immunity Malaria Merozoite Surface Protein 1 Plasmodium yoelii Polymorphism Single Nucleotide Protozoan Proteins Receptors Cell Surface Virulence

Plasmodium vivax malaria is much less common in Africa than the rest of the world because the parasite relies primarily on the Duffy antigen/chemokine receptor (DARC) to invade human erythrocytes, and the majority of Africans...

Antigens Protozoan DNA Copy Number Variations DNA Protozoan Duffy Blood-Group System Erythrocytes Ethiopia Genome Protozoan Humans Malaria Vivax Phylogeny Plasmodium vivax Polymorphism Single Nucleotide Protozoan Proteins Receptors Cell Surface whole genome sequencing

BACKGROUND: Testosterone supplementation has been linked to increased cardiovascular disease risk in some observational studies. The causal role of testosterone can be investigated using a Mendelian randomization approach....

causal inference Disease aetiology Genetic epidemiology Mendelian randomization sex hormones Testosterone Adiponectin Aged Anthropometry blood pressure Coronary Artery Disease Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Humans Jumonji Domain-Containing Histone Demethylases Lipids Male Mendelian Randomization Analysis Middle Aged Oxidoreductases N-Demethylating Receptors Cell Surface Risk Factors stroke Testosterone United Kingdom United States

Fbxo7/PARK15 Tomm20 glycogen synthase kinase mitophagy protein array ubiquitin ligases Antigens Neoplasm Cell Cycle Proteins Cell Line Tumor F-Box Proteins Fluorescent Antibody Technique Glycogen Synthase Kinase 3 beta HEK293 Cells Humans Immunoprecipitation Inhibitor of Apoptosis Proteins Membrane Transport Proteins Mitochondrial Precursor Protein Import Complex Proteins Neoplasm Proteins Parkinson Disease Point Mutation Polymorphism Single Nucleotide Receptors Cell Surface SKP Cullin F-Box Protein Ligases TNF Receptor-Associated Factor 2 Ubiquitination

Misfolded or damaged proteins are typically targeted for destruction by proteasome-mediated degradation, but the mammalian ubiquitin machinery involved is incompletely understood. Here, using forward genetic screens in human...

ERAD MARCH6 TRC8 intramembrane proteolysis protein quality control Endoplasmic Reticulum Gene Knockout Techniques HeLa Cells Heme Oxygenase-1 Humans Mass Spectrometry Membrane Proteins Proteolysis Receptors Cell Surface Ubiquitin-Protein Ligases Ubiquitination

Antigen-Presenting Cells B7-2 Antigen Cells Cultured Dendritic Cells Down-Regulation Humans Immunophenotyping Interleukin-10 Interleukin-8 MACROPHAGES Membrane Glycoproteins Receptors Cell Surface Receptors Immunologic Salmonella Infections Salmonella typhimurium Up-Regulation

The regulated turnover of endoplasmic reticulum (ER)-resident membrane proteins requires their extraction from the membrane lipid bilayer and subsequent proteasome-mediated degradation. Cleavage within the transmembrane domain...

Aspartic Acid Endopeptidases HeLa Cells Heme Oxygenase-1 Humans Membrane Proteins Protein Structure Tertiary Proteolysis Proteomics Receptors Cell Surface Ubiquitination

Animals Case-Control Studies Cell Lineage Duffy Blood-Group System Endothelial Cells Female Hepatic Stellate Cells Hepatocytes Humans Liver Liver Cirrhosis MACROPHAGES Male Membrane Glycoproteins Membrane Proteins Mice Phenotype Receptor Platelet-Derived Growth Factor alpha Receptors Cell Surface Receptors Immunologic Single-Cell Analysis Tetraspanin 29 Transcriptome Transendothelial and Transepithelial Migration

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective...

ATP-Binding Cassette Transporters Animals Databases Pharmaceutical Humans Ion Channels Ligands Pharmaceutical Preparations Protein Transport Proteins Receptors Cell Surface Receptors Cytoplasmic and Nuclear

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2-4 after infection with SARS-CoV-2. The GenOMICC...

ATP-Binding Cassette Transporters covid-19 Cell Adhesion Molecules Critical Care Critical Illness E-Selectin Factor VIII Fucosyltransferases Genome Human Genome-Wide Association Study Host-Pathogen Interactions Humans Interleukin-10 Receptor beta Subunit Lectins C-Type Mucin-1 Nerve Tissue Proteins Phospholipid Transfer Proteins Receptors Cell Surface Repressor Proteins SARS-CoV-2 whole genome sequencing