Search
Results: 123
Is information provided within chronic subdural haematoma education resources adequate? A scoping review.
Conor S Gillespie, Samuel Khanna, Mark E Vivian, Samuel McKoy, Alvaro Yanez Touzet, Ellie Edlmann, Daniel J Stubbs, Benjamin M Davies
Apr 17, 2023
Background
Chronic subdural haematoma (CSDH) is becoming increasingly prevalent, due to an aging population with increasing risk factors. Due to its variable disease course and high morbidity, patient centred care and...
Published by: PLOS ONE
Drug-perturbation-based stratification of blood cancer.
Sascha Dietrich, Małgorzata Oleś, Junyan Lu, Leopold Sellner, Simon Anders, Britta Velten, Bian Wu, Jennifer Hüllein, Michelle da Silva Liberio, Tatjana Walther, Lena Wagner, Sophie Rabe, Sonja Ghidelli-Disse, Marcus Bantscheff, Andrzej K Oleś, Mikołaj Słabicki, Andreas Mock, Christopher C Oakes, Shihui Wang, Sina Oppermann, Marina Lukas, Vladislav Kim, Martin Sill, Axel Benner, Anna Jauch, Lesley Ann Sutton, Emma Young, Richard Rosenquist, Xiyang Liu, Alexander Jethwa, Kwang Seok Lee, Joe Lewis, Kerstin Putzker, Christoph Lutz, Davide Rossi, Andriy Mokhir, Thomas Oellerich, Katja Zirlik, Marco Herling, Florence Nguyen-Khac, Christoph Plass, Emma Andersson, Satu Mustjoki, Christof von Kalle, Anthony D Ho, Manfred Hensel, Jan Dürig, Ingo Ringshausen, Marc Zapatka, Wolfgang Huber, Thorsten Zenz
Mar 08, 2018
As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here...
ANCA-Associated Glomerulonephritis
Arda Göçeroğlu, Annelies E Berden, Marta Fiocco, Oliver Flossmann, Kerstin W Westman, Franco Ferrario, Gill Gaskin, Charles D Pusey, E Christiaan Hagen, Laure-Hélène Noël, Niels Rasmussen, Rüdiger Waldherr, Michael Walsh, Jan A Bruijn, David RW Jayne, Ingeborg M Bajema, European Vasculitis Society (EUVAS)
Feb 24, 2020
Relapse in ANCA-associated vasculitis (AAV) has been studied previously, but there are few studies on renal relapse in particular. Identifying patients at high risk of renal relapse may aid in optimizing clinical management. We...
Aged Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Antineutrophil Cytoplasmic Chronic Disease Europe Female Follow-Up Studies Glomerular Filtration Rate glomerulonephritis Humans Incidence Kidney Kidney Failure Chronic Male Middle Aged Proportional Hazards Models Recurrence Regression Analysis Risk Factors Treatment Outcome
Chronic Inflammatory Disease in the Pancreas, Kidney and Salivary Glands of English Cocker Spaniels and Dogs of Other Breeds Shows Similar Histological Features to Human IgG4-related Disease.
Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma
Ellie Edlmann, Eric P Thelin, Karen Caldwell, Carole Turner, Peter Whitfield, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A Anderson, Oliver Richards, Monica Gherle, Emma Toman, Dipankar Nandi, Phillip Kane, Beatrice Pantaleo, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J Marcus, Aswin Chari, Antonio Belli, Simon Bond, Rafael Gafoor, Sarah Dawson, Lynne Whitehead, Paul Brennan, Ian Wilkinson, Angelos G Kolias, Peter JA Hutchinson, Dex-CSDH trial collaborative and BNTRC collaborative.
Mar 08, 2019
Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.
Harriet CT Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye, Kate N Bishop
Mar 21, 2019
BACKGROUND: Detection of a retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), has recently been reported in 67% of patients with chronic fatigue syndrome. We have studied a total of 170 samples from chronic...
The immunological response to traumatic brain injury.
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults in the developed world. The accuracy of early outcome-prediction remains poor even when all known prognostic factors are considered...
Adaptive immune system Autoimmunity innate immune system Neuroinflammation Traumatic brain injury Adaptive Immunity Alarmins Animals Astrocytes Autoantibodies Autoimmune Diseases of the Nervous System Brain Damage Chronic Brain Injuries Traumatic Cytokines Humans Immunity Innate immunomodulation Lymphocyte Subsets Mice Mice Knockout Microglia Neurodegenerative Diseases Neutrophils pattern recognition Automated Rats Time Factors
Estimating the number of people with hepatitis C virus who have ever injected drugs and have yet to be diagnosed
Teresa C Prevost, Anne M Presanis, Avril Taylor, David J Goldberg, Sharon J Hutchinson, Daniela De Angelis
Jul 11, 2018
AIMS: To estimate the number of people who have ever injected drugs (defined here as PWID) living in Scotland in 2009 who have been infected with the hepatitis C virus (HCV) and to quantify and characterize the population...
2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of lupus nephritis.
Antonis Fanouriakis, Myrto Kostopoulou, Kim Cheema, Hans-Joachim Anders, Martin Aringer, Ingeborg Bajema, John Boletis, Eleni Frangou, Frederic A Houssiau, Jane Hollis, Adexandre Karras, Francesca Marchiori, Stephen D Marks, Gabriella Moroni, Marta Mosca, Ioannis Parodis, Manuel Praga, Matthias Schneider, Josef S Smolen, Vladimir Tesar, Maria Trachana, Ronald F van Vollenhoven, Alexandre E Voskuyl, YK Onno Teng, Bernadette van Leew, George Bertsias, David Jayne, Dimitrios T Boumpas
Nov 03, 2021
OBJECTIVE: To update the 2012 EULAR/ERA-EDTA recommendations for the management of lupus nephritis (LN). METHODS: Following the EULAR standardised operating procedures, a systematic literature review was performed. Members of a...
Lupus Nephritis Systemic Lupus Erythematosus Treatment Antirheumatic Agents Azathioprine Calcineurin Inhibitors Drug Therapy Combination Europe Glomerular Filtration Rate Glucocorticoids Humans Hydroxychloroquine Immunosuppressive Agents Kidney Failure Chronic Lupus Nephritis Mycophenolic Acid Proteinuria Societies Medical
Anaesthesia Choice for Creation of Arteriovenous Fistula (ACCess) study protocol
Alan Jr Macfarlane, Rachel J Kearns, Marc James Clancy, David Kingsmore, Karen Stevenson, Andrew Jackson, Patrick Mark, Margaret Aitken, Ramani Moonesinghe, Cecilia Vindrola-Padros, Lucian Gaianu, Gavin Pettigrew, Reza Motallebzadeh, Nikolaos Karydis, Alex Vesey, Rita Singh, Thalakunte Muniraju, Stuart Suttie, Alex McConnachie, Kirsty Wetherall, Kariem El-Boghdadly, Rosemary Hogg, Iain Thomson, Vishal Nangalia, Emma Aitken, Access collaborative group, ACCess collaborative group
Jan 28, 2022
INTRODUCTION: Arteriovenous fistulae (AVF) are the 'gold standard' vascular access for haemodialysis. Universal usage is limited, however, by a high early failure rate. Several small, single-centre studies have demonstrated...
adult anaesthesia end-stage renal failure TRANSPLANT SURGERY vascular surgery Anesthesia Local Arteriovenous Fistula Arteriovenous Shunt Surgical Humans Kidney Failure Chronic Multicenter Studies as Topic Randomized Controlled Trials as Topic Renal Dialysis Retrospective Studies Treatment Outcome Vascular Patency
Delivery of biannual ultrasound surveillance for individuals with cirrhosis and cured hepatitis C in the UK.
Victoria Hamill, Will Gelson, Douglas MacDonald, Paul Richardson, Stephen D Ryder, Mark Aldersley, Stuart McPherson, Sumita Verma, Rohini Sharma, Sharon Hutchinson, Jennifer Benselin, Eleanor Barnes, Indra Neil Guha, William L Irving, Hamish Innes
Feb 20, 2023
Smoking, alcohol consumption, and 24 gastrointestinal diseases
Shuai Yuan, Jie Chen, Xixian Ruan, Yuhao Sun, Ke Zhang, Xiaoyan Wang, Xue Li, Dipender Gill, Stephen Burgess, Edward Giovannucci, Susanna C Larsson
Mar 15, 2023
Mendelian randomization alcohol consumption EPIDEMIOLOGY Gastrointestinal Diseases Genetics Genomics Global Health None Smoking Humans Mendelian Randomization Analysis Genetic Predisposition to Disease Duodenal Ulcer Smoking Alcohol Drinking Esophageal Neoplasms Liver Diseases Alcoholic Gastritis Pancreatitis Chronic Genome-Wide Association Study Polymorphism Single Nucleotide
Chronic subdural haematoma
Peter Hutchinson is supported by a Research Professorship from the National Institute for Health Research (NIHR), the NIHR Cambridge Biomedical Research Centre, a European Union Seventh Framework Program grant (CENTER-TBI; grant...
Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation
Menno Pruijm, Iosif A Mendichovszky, Per Liss, Patricia Van der Niepen, Stephen C Textor, Lilach O Lerman, CT Paul Krediet, Anna Caroli, Michel Burnier, Pottumarthi Vara Prasad
Sep 20, 2018
PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL).
B cells provide immunity to extracellular pathogens by secreting a diverse repertoire of antibodies with high affinity and specificity for exposed antigens. The B cell receptor (BCR) is a transmembrane antibody, which...
Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia.
Velislava N Petrova, Luke Muir, Paul F McKay, George S Vassiliou, Kenneth GC Smith, Paul A Lyons, Colin A Russell, Carl A Anderson, Paul Kellam, Rachael JM Bashford-Rogers
Nov 05, 2018
B cells B-cell receptor seq chronic lymphocytic leukemia isotype switching repertoire analysis B-Lymphocytes Gene Rearrangement B-Lymphocyte Humans Immunoglobulin Class Switching Immunoglobulin Isotypes Immunoglobulin Joining Region Immunoglobulin Variable Region Leukemia Lymphocytic Chronic B-Cell Leukocytes Mononuclear Multigene Family Receptors Antigen B-Cell Somatic Hypermutation Immunoglobulin
Ischemia-reperfusion injury in renal transplantation
Renal ischemia-reperfusion injury (IRI) is a significant clinical challenge faced by clinicians perioperatively in kidney transplantation. Recent work has demonstrated the key importance of transmembrane receptors in the injured...
ischemia-reperfusion injury tubular epithelial cells Allografts Basic Helix-Loop-Helix Transcription Factors Clinical Trials Phase II as Topic Epithelial Cells Humans Hypoxia-Inducible Factor 1 Kidney Failure Chronic Kidney Transplantation Kidney Tubules Receptors Lysosphingolipid Reperfusion Injury Signal Transduction Toll-Like Receptors
A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population.
Konstantinos Voskarides, Charalambos Stefanou, Myrtani Pieri, Panayiota Demosthenous, Kyriakos Felekkis, Maria Arsali, Yiannis Athanasiou, Dimitris Xydakis, Kostas Stylianou, Eugenios Daphnis, Giorgos Goulielmos, Petros Loizou, Judith Savige, Martin Höhne, Linus A Völker, Thomas Benzing, Patrick H Maxwell, Daniel P Gale, Mathias Gorski, Carsten Böger, Barbara Kollerits, Florian Kronenberg, Bernhard Paulweber, Michalis Zavros, Alkis Pierides, Constantinos Deltas
Feb 07, 2019
BACKGROUND: Recent data emphasize that thin basement membrane nephropathy (TBMN) should not be viewed as a form of benign familial hematuria since chronic renal failure (CRF) and even end-stage renal disease (ESRD), is a...
Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life
Ji-Yeon Lee, Kyungdo Han, Eugene Han, Gyuri Kim, Hanna Cho, Kwang Joon Kim, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Carol Brayne, Yong-Ho Lee
Mar 15, 2019
CONTEXT: The risk for dementia among subjects who are obese with normal metabolic profiles, or called metabolically healthy obese (MHO), remains uninvestigated. OBJECTIVE: To determine the association between late-life metabolic...
Aged Alzheimer Disease Blood Glucose Cholesterol HDL Cholesterol LDL Cohort Studies Comorbidity Dementia Dementia Vascular Diabetes mellitus Female Humans Hyperlipidemias Hypertension Incidence Male Metabolic Syndrome Middle Aged obesity obesity Metabolically Benign Renal Insufficiency Chronic Republic of Korea Retrospective Studies Risk Factors Thinness Triglycerides
A Simple Clinical Tool for Stratifying Risk of Clinically Significant CKD after Nephrectomy
Robert J Ellis, Sharon J Del Vecchio, Kevin MJ Gallagher, Danielle N Aliano, Neil Barber, Damien M Bolton, Etienne TS Chew, Jeff S Coombes, Michael D Coory, Ian D Davis, James F Donaldson, Ross S Francis, Graham G Giles, Glenda C Gobe, Carmel M Hawley, David W Johnson, Alexander Laird, Steve Leung, Manar Malki, David JT Marco, Alan S McNeill, Rachel E Neale, Keng L Ng, Simon Phipps, Grant D Stewart, Victoria M White, Simon T Wood, Susan J Jordan
Apr 06, 2020
BACKGROUND: Clinically significant CKD following surgery for kidney cancer is associated with increased morbidity and mortality, but identifying patients at increased CKD risk remains difficult. Simple methods to stratify risk...
Nephrectomy chronic kidney disease Glomerular Filtration Rate kidney cancer renal cell carcinoma Risk stratification Aged Aged 80 and over Evidence-Based Medicine Female Glomerular Filtration Rate Humans Kidney Neoplasms Logistic Models Male Middle Aged Nephrectomy Postoperative Complications Renal Insufficiency Chronic Reproducibility of Results Risk Assessment Sensitivity and Specificity Severity of Illness Index
A practical guide for mutational signature analysis in hematological malignancies.
Francesco Maura, Andrea Degasperi, Ferran Nadeu, Daniel Leongamornlert, Helen Davies, Luiza Moore, Romina Royo, Bachisio Ziccheddu, Xose S Puente, Herve Avet-Loiseau, Peter J Cambell, Serena Nik-Zainal, Elias Campo, Nikhil Munshi, Niccolò Bolli
Jul 15, 2019
Using structural and functional MRI as a neuroimaging technique to investigate chronic fatigue syndrome/myalgic encephalopathy
OBJECTIVE: This systematic review aims to synthesise and evaluate structural MRI (sMRI) and functional MRI (fMRI) studies in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). METHODS: We systematically searched...
Randomised controlled trial of prolonged treatment in the remission phase of ANCA-associated vasculitis.
Alexandre Karras, Christian Pagnoux, Marion Haubitz, Kirsten de Groot, Xavier Puechal, Jan Willem Cohen Tervaert, Mårten Segelmark, Loic Guillevin, David Jayne, European Vasculitis Society
Feb 27, 2020
OBJECTIVES: A prospective randomised trial to compare two different durations of maintenance immunosuppressive therapy for the prevention of relapse in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV)....
ANCA Azathioprine maintenance therapy Relapse Vasculitis Adult Aged Anti-Inflammatory Agents Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Antineutrophil Cytoplasmic Azathioprine Creatinine cyclophosphamide Female Glomerular Filtration Rate Humans Immunosuppressive Agents Kidney Failure Chronic Maintenance Chemotherapy Male Middle Aged Prednisolone Prospective Studies Remission Induction Secondary Prevention Survival Rate Time Factors
Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial
Angelos G Kolias, Ellie Edlmann, Eric P Thelin, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A Anderson, Oliver Richards, Peter Whitfield, Monica Gherle, Karen Caldwell, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J Marcus, Aswin Chari, Paul Brennan, Antonio Belli, Simon Bond, Carole Turner, Lynne Whitehead, Ian Wilkinson, Peter J Hutchinson, British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators
Feb 07, 2019
BACKGROUND: Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20%...
chronic subdural haematoma Dexamethasone Neurology Neurosurgery Randomised control trial Cost-Benefit Analysis Dexamethasone Double-Blind Method Drug Administration Schedule Drug Costs Glucocorticoids Hematoma Subdural Chronic Humans Multicenter Studies as Topic Randomized Controlled Trials as Topic Time Factors Treatment Outcome United Kingdom
|
|< |
< |
1 |