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Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes.
Marco Colombo, Stuart J McGurnaghan, Luke AK Blackbourn, R Neil Dalton, David Dunger, Samira Bell, John R Petrie, Fiona Green, Sandra MacRury, John A McKnight, John Chalmers, Andrew Collier, Paul M McKeigue, Helen M Colhoun, Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators
Jan 07, 2021
AIMS/HYPOTHESIS: We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression in type 1 diabetes beyond prior eGFR, comparing their performance with urinary...
Clinical science EPIDEMIOLOGY Metabolomics Nephropathy Proteomics Adult Aged Albumins Albuminuria Biomarkers Blood Chemical Analysis Cohort Studies Creatinine Diabetes mellitus Type 1 Diabetic Nephropathies Diagnostic Techniques Endocrine Enzyme-Linked Immunosorbent Assay Female Humans Kidney Function Tests Male Middle Aged Prognosis Prospective Studies Scotland Serum Albumin Urinalysis
Mixed-meal tolerance test to assess residual beta-cell secretion
Yue Ruan, Ruben H Willemsen, Malgorzata E Wilinska, Martin Tauschmann, David B Dunger, Roman Hovorka
Feb 05, 2019
AIMS: Residual beta-cell secretion in type 1 diabetes is commonly assessed by area-under-curve of plasma C-peptide concentration (AUCCpep ) following mixed-meal tolerance test (MMTT). We aimed to investigate alternative measures...
C-Peptide beta-cell secretion mixed-meal tolerance test type 1 diabetes Adolescent Area Under Curve Blood Glucose C-Peptide Child Diabetes mellitus Type 1 Diagnostic Techniques Endocrine Feasibility Studies Female Glycated Hemoglobin Humans Insulin Secretion Insulin-Secreting Cells Male Meals Postprandial Period