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Cover Image for New therapeutic approaches for Krabbe disease

New therapeutic approaches for Krabbe disease

Samantha J Spratley, Janet E Deane

May 03, 2016

GALC Krabbe disease galactocerebroside lysosomal storage disorder pharmacological chaperone therapy β-galactocerebrosidase Animals Enzyme Replacement Therapy Galactosylceramidase Humans Leukodystrophy Globoid Cell Molecular Chaperones

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Cover Image for Expression of Ripk1 and DAM genes correlates with severity and progression of Krabbe disease.

Expression of Ripk1 and DAM genes correlates with severity and progression of Krabbe disease.

María B Cachón-González, Susan Wang, Timothy M Cox

Jun 22, 2021

Animals Autophagosomes Biomarkers Disease Models Animal Disease Progression Disease Susceptibility Gene Expression Gene Knockdown Techniques Humans Leukodystrophy Globoid Cell Mice Microglia Neuroinflammatory Diseases Protein Transport Receptor-Interacting Protein Serine-Threonine Kinases Severity of Illness Index Transcriptome

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Cover Image for Molecular Mechanisms of Disease Pathogenesis Differ in Krabbe Disease Variants.

Molecular Mechanisms of Disease Pathogenesis Differ in Krabbe Disease Variants.

Samantha J Spratley, Chris H Hill, Agnete H Viuff, James R Edgar, Karsten Skjødt, Janet E Deane

Apr 26, 2016

Krabbe disease galactocerebrosidase globoid cell leukodystrophy glycosphingolipid lysosomal storage disease Cell Line Galactosylceramidase Humans Leukodystrophy Globoid Cell Lysosomes Mutation Protein Processing Post-Translational

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