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The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome.
Emma J Crosbie, Neil AJ Ryan, Mark J Arends, Tjalling Bosse, John Burn, Joanna M Cornes, Robin Crawford, Diana Eccles, Ian M Frayling, Sadaf Ghaem-Maghami, Heather Hampel, Noah D Kauff, Henry C Kitchener, Sarah J Kitson, Ranjit Manchanda, Raymond FT McMahon, Kevin J Monahan, Usha Menon, Pål Møller, Gabriela Möslein, Adam Rosenthal, Peter Sasieni, Mourad W Seif, Naveena Singh, Pauline Skarrott, Tristan M Snowsill, Robert Steele, Marc Tischkowitz, Manchester International Consensus Group, D Gareth Evans
Feb 07, 2020
PURPOSE: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with...
Penetrance estimates for BRCA1, BRCA2 (also applied to Lynch syndrome) based on presymptomatic testing
D Gareth Evans, Emma Woodward, Elaine F Harkness, Anthony Howell, Inga Plaskocinska, Eamonn R Maher, Marc D Tischkowitz, Fiona Lalloo
Jul 02, 2018
PURPOSE: The identification of BRCA1, BRCA2 or mismatch repair (MMR) pathogenic gene variants in familial breast/ovarian/colorectal cancer families facilitates predictive genetic testing of at-risk relatives. However...
Lynch syndrome BRCA1 BRCA2 Penetrance pre-symptomatic Adult Aged BRCA1 Protein BRCA2 Protein Bayes Theorem Breast Neoplasms Colorectal Neoplasms Hereditary Nonpolyposis Female Genetic Predisposition to Disease Genetic Testing Humans Male Middle Aged MutL Protein Homolog 1 MutS Homolog 2 Protein Mutation Ovarian Neoplasms Penetrance Risk Assessment
Benjamin G Challis, Narayanan Kandasamy, Andrew S Powlson, Olympia Koulouri, Anand Kumar Annamalai, Lisa Happerfield, Alison J Marker, Mark J Arends, Serena Nik-Zainal, Mark Gurnell
May 12, 2016
Mutational landscape of normal epithelial cells in Lynch Syndrome patients.
Bernard CH Lee, Philip S Robinson, Tim HH Coorens, Helen HN Yan, Sigurgeir Olafsson, Henry Lee-Six, Mathijs A Sanders, Hoi Cheong Siu, James Hewinson, Sarah SK Yue, Wai Yin Tsui, Annie SY Chan, Anthony KW Chan, Siu Lun Ho, Peter J Campbell, Inigo Martincorena, Simon JA Buczacki, Siu Tsan Yuen, Suet Yi Leung, Michael R Stratton
Jun 29, 2022
Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic...
Adenomas as a risk factor in familial colorectal cancer
Adenoma Adenomatous Polyposis Coli Carcinoma Colonic Polyps Colonoscopy Colorectal Neoplasms Colorectal Neoplasms Hereditary Nonpolyposis Databases Factual Early Detection of Cancer Genetic Predisposition to Disease Health Care Costs Humans Medical History Taking Models Theoretical Pedigree Practice Guidelines as Topic Risk Assessment State Medicine United Kingdom