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The devil's in the detail
Models of memory propose that separate systems underpin the storage and recollection of specific events from our past (e.g., the first day at school), and of the generic structure of our experiences (e.g., how lonely I am), and...
Discrimination in the workplace, reported by people with major depressive disorder
EPM Brouwers, J Mathijssen, T Van Bortel, L Knifton, K Wahlbeck, C Van Audenhove, N Kadri, Ch Chang, BR Goud, D Ballester, LF Tófoli, R Bello, MF Jorge-Monteiro, H Zäske, I Milaćić, A Uçok, C Bonetto, A Lasalvia, G Thornicroft, J Van Weeghel, ASPEN/INDIGO Study Group*
Feb 27, 2019
OBJECTIVE: Whereas employment has been shown to be beneficial for people with Major Depressive Disorder (MDD) across different cultures, employers' attitudes have been shown to be negative towards workers with MDD. This may form...
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.
Loes CA Rutten-Jacobs, Daniel J Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S Markus, Matthew Traylor
Sep 05, 2018
BACKGROUND AND PURPOSE: Structural integrity of the white matter is a marker of cerebral small vessel disease, which is the major cause of vascular dementia and a quarter of all strokes. Genetic studies provide a way to obtain...
cerebral small vessel diseases Diffusion tensor imaging Genetic Association Studies Humans white matter Adult Aged Biological Specimen Banks cerebral small vessel diseases Dementia Depression Depressive Disorder Major Diffusion Magnetic Resonance Imaging Female Genome-Wide Association Study Humans Male Middle Aged stroke United Kingdom white matter
Generalised anxiety disorder and hospital admissions
Olivia Remes, Nicholas Wainwright, Paul Surtees, Louise Lafortune, Kay-Tee Khaw, Carol Brayne
Jun 12, 2018
OBJECTIVE: Generalised anxiety disorder (GAD) is the most common anxiety disorder in the general population and has been associated with high economic and human burden. However, it has been neglected in the health services...
EPIDEMIOLOGY Mental Health Public Health Adult Age Distribution Aged Anxiety Disorders Comorbidity Depressive Disorder Major Diagnostic and Statistical Manual of Mental Disorders England Female Humans Longitudinal Studies Male Middle Aged Patient Admission Prospective Studies Registries Self Report Sex Distribution
Adolescents with current major depressive disorder show dissimilar patterns of age-related differences in ACC and thalamus.
Cindy C Hagan, Julia ME Graham, Roger Tait, Barry Widmer, Adrienne O van Nieuwenhuizen, Cinly Ooi, Kirstie J Whitaker, Tiago Simas, Edward T Bullmore, Belinda R Lennox, Barbara J Sahakian, Ian M Goodyer, John Suckling
Apr 01, 2015
Case report
BACKGROUND: Major depressive disorder and associated mood syndromes are amongst the most common psychiatric disorders. To date, electroconvulsive therapy (ECT) is considered the most effective short-term treatment for patients...
Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis.
Jingying Wang, Huichun Luo, Rasmus Schülke, Xinyi Geng, Barbara J Sahakian, Shouyan Wang
Jan 05, 2022
BACKGROUND: Transcranial direct current stimulation (tDCS) has shown mixed results for depression treatment. The efficacies of tDCS combination therapies have not been investigated deliberately. This review aims to evaluate the...
Thyroid Function and Mood Disorders
Aleksander Kuś, Alisa D Kjaergaard, Eirini Marouli, Fabiola del Greco M, Rosalie BTM Sterenborg, Layal Chaker, Robin P Peeters, Tomasz Bednarczuk, Bjørn O Åsvold, Stephen Burgess, Panos Deloukas, Alexander Teumer, Christina Ellervik, Marco Medici
Apr 28, 2021
Background: Observational studies suggest that even minor variations in thyroid function are associated with the risk of mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). However, it is unknown...
Mendelian randomization study Bipolar Disorder Depression Mood Disorders normal-range thyroid function Thyroid Adult Bipolar Disorder Depressive Disorder Major Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Mood Disorders risk Thyroid Function Tests Thyroid Gland Thyrotropin Thyroxine
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
Till FM Andlauer, Jose Guzman-Parra, Fabian Streit, Jana Strohmaier, Maria José González, Susana Gil Flores, Francisco J Cabaleiro Fabeiro, Francisco Del Río Noriega, Fermin Perez Perez, Jesus Haro González, Guillermo Orozco Diaz, Yolanda de Diego-Otero, Berta Moreno-Küstner, Georg Auburger, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Stefan Herms, Per Hoffmann, Josef Frank, Jerome C Foo, Jens Treutlein, Stephanie H Witt, Sven Cichon, Manolis Kogevinas, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Fabio Rivas, Fermín Mayoral, Bertram Müller-Myhsok, Andreas J Forstner, Markus M Nöthen, Marcella Rietschel
Mar 22, 2021
Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD...
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus
Johann Steiner, Martin Walter, Tomasz Gos, Gilles J Guillemin, Hans-Gert Bernstein, Zoltán Sarnyai, Christian Mawrin, Ralf Brisch, Hendrik Bielau, Louise Meyer zu Schwabedissen, Bernhard Bogerts, Aye-Mu Myint
Sep 23, 2011
BDNF Val66Met polymorphism in patterns of neural activation in individuals with MDD and healthy controls.
Danuta M Lisiecka, Erik O'Hanlon, Andrew J Fagan, Angela Carballedo, Derek Morris, John Suckling, Thomas Frodl
Jun 24, 2015
Brain-Derived Neurotrophic Factor Emotional response functional magnetic resonance imaging Major depressive disorder Prefrontal Cortex Striatum Adult Alleles Brain Brain-Derived Neurotrophic Factor Case-Control Studies Depressive Disorder Major Emotions Female Functional Neuroimaging Genotype Humans Magnetic Resonance Imaging Male Middle Aged Polymorphism Single Nucleotide
Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients.
M Heslin, JM Lappin, K Donoghue, B Lomas, U Reininghaus, A Onyejiaka, T Croudace, PB Jones, RM Murray, P Fearon, GA Doody, P Dazzan, TJ Craig, C Morgan
May 13, 2016
Depression outcomes Prognosis Psychosis Psychotic major depression Adult Bipolar Disorder Depressive Disorder Major employment Female Follow-Up Studies Humans Incidence Male Prisons Psychotic Disorders Regression Analysis Schizophrenia Self-Injurious Behavior Social Isolation Treatment Outcome Young Adult
Functional MRI of emotional memory in adolescent depression.
Rosemary J Holt, Julia M Graham, Kirstie J Whitaker, Cindy C Hagan, Cinly Ooi, Paul O Wilkinson, Adrienne O van Nieuwenhuizen, Belinda R Lennox, Barbara J Sahakian, Ian M Goodyer, Edward T Bullmore, John Suckling
Jan 13, 2016
Memory Flexibility training (MemFlex) to reduce depressive symptomatology in individuals with major depressive disorder
Caitlin Hitchcock, Emily Hammond, Catrin Rees, Inderpal Panesar, Peter Watson, Aliza Werner-Seidler, Tim Dalgleish
Jan 21, 2020
BACKGROUND: Major depressive disorder (MDD) is associated with chronic biases in the allocation of attention and recollection of personal memories. Impaired flexibility in attention and autobiographical memory retrieval is seen...
A randomised controlled trial of memory flexibility training (MemFlex) to enhance memory flexibility and reduce depressive symptomatology in individuals with major depressive disorder.
Caitlin Hitchcock, Siobhan Gormley, Catrin Rees, Evangeline Rodrigues, Julia Gillard, Inderpal Panesar, Isobel M Wright, Emily Hammond, Peter Watson, Aliza Werner-Seidler, Tim Dalgleish
Mar 25, 2019
UNLABELLED: Successful navigation within the autobiographical memory store is integral to daily cognition. Impairment in the flexibility of memory retrieval can thereby have a detrimental impact on mental health. This randomised...
A machine learning algorithm to differentiate bipolar disorder from major depressive disorder using an online mental health questionnaire and blood biomarker data.
Jakub Tomasik, Sung Yeon Sarah Han, Giles Barton-Owen, Dan-Mircea Mirea, Nayra A Martin-Key, Nitin Rustogi, Santiago G Lago, Tony Olmert, Jason D Cooper, Sureyya Ozcan, Pawel Eljasz, Grégoire Thomas, Robin Tuytten, Tim Metcalfe, Thea S Schei, Lynn P Farrag, Lauren V Friend, Emily Bell, Dan Cowell, Sabine Bahn
Mar 08, 2021
The vast personal and economic burden of mood disorders is largely caused by their under- and misdiagnosis, which is associated with ineffective treatment and worsening of outcomes. Here, we aimed to develop a diagnostic...
Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system.
Miruna C Barbu, Floris Huider, Archie Campbell, Carmen Amador, Mark J Adams, Mary-Ellen Lynall, David M Howard, Rosie M Walker, Stewart W Morris, Jenny van Dongen, David J Porteous, Kathryn L Evans, Edward Bullmore, Gonneke Willemsen, Dorret I Boomsma, Heather C Whalley, Andrew M McIntosh
May 12, 2022
Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder
Benjamin I Perry, Rachel Upthegrove, Nils Kappelmann, Peter B Jones, Stephen Burgess, Golam M Khandaker
Jul 19, 2021
Neural correlates of three types of negative life events during angry face processing in adolescents.
Fanny Gollier-Briant, Marie-Laure Paillère-Martinot, Hervé Lemaitre, Ruben Miranda, Hélène Vulser, Robert Goodman, Jani Penttilä, Maren Struve, Tahmine Fadai, Viola Kappel, Luise Poustka, Yvonne Grimmer, Uli Bromberg, Patricia Conrod, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Christian Büchel, Herta Flor, Juergen Gallinat, Hugh Garavan, Andreas Heinz, Claire Lawrence, Karl Mann, Frauke Nees, Tomas Paus, Zdenka Pausova, Vincent Frouin, Marcella Rietschel, Trevor W Robbins, Michael N Smolka, Gunter Schumann, IMAGEN Consortium+, Jean-Luc Martinot, Eric Artiges
May 21, 2018
Negative life events (NLE) contribute to anxiety and depression disorders, but their relationship with brain functioning in adolescence has rarely been studied. We hypothesized that neural response to social threat would relate...
A cluster randomized controlled platform trial comparing group MEmory specificity training (MEST) to group psychoeducation and supportive counselling (PSC) in the treatment of recurrent depression.
Aliza Werner-Seidler, Caitlin Hitchcock, Anna Bevan, Anna McKinnon, Julia Gillard, Theresa Dahm, Isobel Chadwick, Inderpal Panesar, Lauren Breakwell, Viola Mueller, Evangeline Rodrigues, Catrin Rees, Siobhan Gormley, Susanne Schweizer, Peter Watson, Filip Raes, Laura Jobson, Tim Dalgleish
Jul 13, 2018
Impaired ability to recall specific autobiographical memories is characteristic of depression, which when reversed, may have therapeutic benefits. This cluster-randomized controlled pilot trial investigated efficacy and aspects...
Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.
Benjamin U Phillips, Sigma Dewan, Simon RO Nilsson, Trevor W Robbins, Christopher J Heath, Lisa M Saksida, Timothy J Bussey, Johan Alsiö
Jul 13, 2018
RATIONALE: Dysregulation of the serotonin (5-HT) system is a pathophysiological component in major depressive disorder (MDD), a condition closely associated with abnormal emotional responsivity to positive and negative feedback....
5-HT2C receptor SB 242084 WAY 163909 Aminopyridines Animals Azepines Depressive Disorder Major Discrimination Learning Indoles Male Mice Probability Learning Receptor Serotonin 5-HT2C Reinforcement psychology Reversal Learning Serotonin 5-HT2 Receptor Agonists Serotonin 5-HT2 Receptor Antagonists Task Performance and Analysis Visual Perception
Subgenual activation and the finger of blame
Karen E Lythe, Jennifer A Gethin, Clifford I Workman, Matthew A Lambon Ralph, John FW Deakin, Jorge Moll, Roland Zahn
Oct 01, 2020
BACKGROUND: Subgenual cingulate cortex (SCC) responses to self-blaming emotion-evoking stimuli were previously found in individuals prone to self-blame with and without a history of major depressive disorder (MDD). This...
Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures.
Jiao Li, Jakob Seidlitz, John Suckling, Feiyang Fan, Gong-Jun Ji, Yao Meng, Siqi Yang, Kai Wang, Jiang Qiu, Huafu Chen, Wei Liao
Mar 18, 2021
Major depressive disorder (MDD) has been shown to be associated with structural abnormalities in a variety of spatially diverse brain regions. However, the correlation between brain structural changes in MDD and gene expression...
No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing.
John J Cole, Alison McColl, Robin Shaw, Mary-Ellen Lynall, Philip J Cowen, Peter de Boer, Wayne C Drevets, Neil Harrison, Carmine Pariante, Linda Pointon, NIMA Consortium, Carl Goodyear, Edward Bullmore, Jonathan Cavanagh
Jun 04, 2021
The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation forthe variance in this heterogeneous condition. Peripheral blood...
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