Mechanical-Stress-Related Epigenetic Regulation of ZIC1 Transcription Factor in the Etiology of Postmenopausal Osteoporosis.
Harish K Datta,
Marianne K Kringen,
Stephen P Tuck,
Georgia Salpingidou,
Ole K Olstad,
Kaare M Gautvik,
Simon J Cockell,
Vigdis T Gautvik,
Michael Prediger,
Jun Jie Wu,
Mark A Birch,
Sjur Reppe
Mar 10, 2022
Mechanical loading exerts a profound influence on bone density and architecture, but the exact mechanism is unknown. Our study shows that expression of the neurological transcriptional factor zinc finger of the cerebellum 1...