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Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia.
Charles C Bell, Katie A Fennell, Yih-Chih Chan, Florian Rambow, Miriam M Yeung, Dane Vassiliadis, Luis Lara, Paul Yeh, Luciano G Martelotto, Aljosja Rogiers, Brandon E Kremer, Olena Barbash, Helai P Mohammad, Timothy M Johanson, Marian L Burr, Arindam Dhar, Natalie Karpinich, Luyi Tian, Dean S Tyler, Laura MacPherson, Junwei Shi, Nathan Pinnawala, Chun Yew Fong, Anthony T Papenfuss, Sean M Grimmond, Sarah-Jane Dawson, Rhys S Allan, Ryan G Kruger, Christopher R Vakoc, David L Goode, Shalin H Naik, Omer Gilan, Enid YN Lam, Jean-Christophe Marine, Rab K Prinjha, Mark A Dawson
Aug 21, 2019
Non-genetic drug resistance is increasingly recognised in various cancers. Molecular insights into this process are lacking and it is unknown whether stable non-genetic resistance can be overcome. Using single cell...
Animals Antineoplastic Agents Bone Marrow CRISPR-Cas Systems Cell Line Tumor Drug Resistance Neoplasm Epigenesis Genetic Female Gene Expression Regulation Leukemic HEK293 Cells Humans Kaplan-Meier Estimate Leukemia Myeloid Acute Mice Mice Inbred C57BL Sequence Analysis RNA Single-Cell Analysis Trans-Activators Transcription Genetic Treatment Outcome Xenograft Model Antitumor Assays