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BACKGROUND AND AIMS: Acute severe colitis [ASC] is associated with major morbidity. We aimed to develop and externally validate an index that predicted ASC within 3 years of diagnosis. METHODS: The development cohort included...

Biomarkers acute severe colitis Clinical Trials PREDICTION Ulcerative colitis Acute Disease Adult Age Factors C-Reactive Protein Colitis Ulcerative Colonoscopy Disease Progression Female Hemoglobins Hospitalization Humans Male Middle Aged Nomograms Predictive Value of Tests Risk Factors Severity of Illness Index Sex Factors

Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 IBD patients and compared these to 412 crypts...

Crohn's Disease IL17 PIGR ZC3H12A inflammatory bowel disease intestinal epithelia Mutation Rate mutational signatures somatic mutations Ulcerative colitis Adult Aged Aged 80 and over aging Clonal Evolution Colitis Colitis Ulcerative Crohn Disease DNA-Binding Proteins Epithelial Cells F-Box-WD Repeat-Containing Protein 7 Female Humans INDEL Mutation Inflammatory Bowel Diseases Interleukin-17 Intestinal Mucosa Male Middle Aged Mutation Rate Phylogeny Point Mutation Receptors Cell Surface Ribonucleases Toll-Like Receptors Transcription Factors whole genome sequencing

OBJECTIVES: Physical activity in paediatric and young adult patients suffering from inflammatory bowel disease (IBD) may play an important role in the overall health status. However, physical activity in these patients has not...

accelerometers Crohn’s Disease Paediatrics physical activity Ulcerative colitis Accelerometry Adolescent Child Chronic Disease Colitis Ulcerative Crohn Disease Exercise Female Humans Inflammatory Bowel Diseases Male Young Adult

Alleles Chromosome Mapping Colitis Ulcerative Crohn Disease Genetic Linkage Genetic Predisposition to Disease Genome-Wide Association Study Genotype Genotyping Techniques HLA-DRB1 Chains Heterozygote Humans Inflammatory Bowel Diseases Major Histocompatibility Complex Phenotype Polymorphism Single Nucleotide

Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a search for protein-truncating variants conferring protection against...

Alleles Colitis Ulcerative Genetic Association Studies Genetic Predisposition to Disease Genetic Testing Humans Mutation Protein Transport RNA Messenger Reproducibility of Results Sequence Analysis DNA Ubiquitin-Protein Ligases

Humans Mice Animals Verrucomicrobia Mucus Lectins Colitis Ulcerative