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In vitro sensitivity of human parainfluenza 3 clinical isolates to ribavirin, favipiravir and zanamivir.
Ten considerations for effectively managing the COVID-19 transition
KB Habersaat, C Betsch, M Danchin, CR Sunstein, R Böhm, A Falk, NT Brewer, SB Omer, M Scherzer, S Sah, EF Fischer, AE Scheel, D Fancourt, S Kitayama, E Dubé, J Leask, M Dutta, NE MacDonald, A Temkina, A Lieberoth, M Jackson, S Lewandowsky, H Seale, N Fietje, P Schmid, M Gelfand, L Korn, S Eitze, L Felgendreff, P Sprengholz, C Salvi, R Butler
Sep 09, 2020
Governments around the world have implemented measures to manage the transmission of coronavirus disease 2019 (COVID-19). While the majority of these measures are proving effective, they have a high social and economic cost, and...
Impact of COVID-19 pandemic on treatment patterns in metastatic clear cell renal cell carcinoma.
Stefanie Aeppli, Eric Innocents Eboulet, Tim Eisen, Bernard Escudier, Stefanie Fischer, James Larkin, Viktor Gruenwald, David McDermott, Jan Oldenburg, Aurelius Omlin, Camillo Porta, Brian Rini, Manuela Schmidinger, Cora Sternberg, Christian Rothermundt
Sep 15, 2020
BACKGROUND: The coronavirus pandemic has provoked discussions among healthcare providers how to manage cancer patients when faced with the threat of severe acute respiratory syndrome related coronavirus 2 (SARS-CoV-2) infection....
covid-19 decision criteria pandemic renal cell carcinoma treatment pattern Antineoplastic Agents Betacoronavirus covid-19 Carcinoma Renal Cell Clinical Decision-Making Coronavirus Infections Humans Immunologic Factors Kidney Neoplasms Medical Oncology Pandemics Pneumonia Viral Practice Patterns Physicians' Protein Kinase Inhibitors SARS-CoV-2 Urology
Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation.
HHV-8 KSHV NK cell receptor ligands herpesvirus host cell restriction factors lytic reactivation Proteomics Viral immune evasion Antigens Differentiation T-Lymphocyte Cell Line DNA-Directed DNA Polymerase Down-Regulation Endothelial Cells Gene Library Gene Ontology Genes Viral Genetic Testing Herpesvirus 8 Human Humans immunomodulation Kinetics Ligands Mutation Proteome Proteomics Sarcoma Kaposi Up-Regulation Viral Proteins Virus Activation eIF-2 Kinase
Metagenomic analyses and genetic diversity of Tomato leaf curl Arusha virus affecting tomato plants in Kenya.
Edith Khamonya Avedi, Adedapo Olutola Adediji, Dora Chao Kilalo, Florence Mmogi Olubayo, Isaac Macharia, Elijah Miinda Ateka, Eunice Magoma Machuka, Josiah Musembi Mutuku
Jan 07, 2021
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
Erik Volz, Verity Hill, John T McCrone, Anna Price, David Jorgensen, Áine O'Toole, Joel Southgate, Robert Johnson, Ben Jackson, Fabricia F Nascimento, Sara M Rey, Samuel M Nicholls, Rachel M Colquhoun, Ana da Silva Filipe, James Shepherd, David J Pascall, Rajiv Shah, Natasha Jesudason, Kathy Li, Ruth Jarrett, Nicole Pacchiarini, Matthew Bull, Lily Geidelberg, Igor Siveroni, COG-UK Consortium, Ian Goodfellow, Nicholas J Loman, Oliver G Pybus, David L Robertson, Emma C Thomson, Andrew Rambaut, Thomas R Connor
Jan 12, 2021
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection...
Dynamic interventions to control COVID-19 pandemic
Rajiv Chowdhury, Kevin Heng, Md Shajedur Rahman Shawon, Gabriel Goh, Daisy Okonofua, Carolina Ochoa-Rosales, Valentina Gonzalez-Jaramillo, Abbas Bhuiya, Daniel Reidpath, Shamini Prathapan, Sara Shahzad, Christian L Althaus, Nathalia Gonzalez-Jaramillo, Oscar H Franco, Global Dynamic Interventions Strategies for COVID-19 Collaborative Group
Aug 07, 2020
To date, non-pharmacological interventions (NPI) have been the mainstay for controlling the coronavirus disease-2019 (COVID-19) pandemic. While NPIs are effective in preventing health systems overload, these long-term measures...
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group, Peter Horby, Marion Mafham, Louise Linsell, Jennifer L Bell, Natalie Staplin, Jonathan R Emberson, Martin Wiselka, Andrew Ustianowski, Einas Elmahi, Benjamin Prudon, Tony Whitehouse, Timothy Felton, John Williams, Jakki Faccenda, Jonathan Underwood, J Kenneth Baillie, Lucy C Chappell, Saul N Faust, Thomas Jaki, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Kathryn Rowan, Joel Tarning, James A Watson, Nicholas J White, Edmund Juszczak, Richard Haynes, Martin J Landray
Dec 17, 2020
BACKGROUND: Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from uncontrolled studies and small, randomized trials. METHODS...
Reductions in commuting mobility correlate with geographic differences in SARS-CoV-2 prevalence in New York City.
Stephen M Kissler, Nishant Kishore, Malavika Prabhu, Dena Goffman, Yaakov Beilin, Ruth Landau, Cynthia Gyamfi-Bannerman, Brian T Bateman, Jon Snyder, Armin S Razavi, Daniel Katz, Jonathan Gal, Angela Bianco, Joanne Stone, Daniel Larremore, Caroline O Buckee, Yonatan H Grad
Nov 02, 2020
SARS-CoV-2-related mortality and hospitalizations differ substantially between New York City neighborhoods. Mitigation efforts require knowing the extent to which these disparities reflect differences in prevalence and...
Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab.
Nicholas A Kennedy, James R Goodhand, Claire Bewshea, Rachel Nice, Desmond Chee, Simeng Lin, Neil Chanchlani, Jeffrey Butterworth, Rachel Cooney, Nicholas M Croft, Ailsa L Hart, Peter M Irving, Klaartje B Kok, Christopher A Lamb, Jimmy K Limdi, Jonathan Macdonald, Dermot PB McGovern, Shameer J Mehta, Charles D Murray, Kamal V Patel, Richard Cg Pollok, Timothy Raine, Richard K Russell, Christian P Selinger, Philip J Smith, Jack Bowden, Timothy J McDonald, Charlie W Lees, Shaji Sebastian, Nicholas Powell, Tariq Ahmad, Contributors to the CLARITY IBD study
Mar 23, 2021
OBJECTIVE: Antitumour necrosis factor (anti-TNF) drugs impair protective immunity following pneumococcal, influenza and viral hepatitis vaccination and increase the risk of serious respiratory infections. We sought to determine...
covid-19 Autoimmune Disease CLARITY inflammatory bowel disease inflammatory diseases Infliximab vedoluzimab Adult Antibodies Monoclonal Humanized Antibodies Viral Antibody Formation covid-19 Female Gastrointestinal Agents Humans Inflammatory Bowel Diseases Infliximab Male Middle Aged Prospective Studies SARS-CoV-2 Serologic Tests United Kingdom
Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.
Vincent CT Mok, Sarah Pendlebury, Adrian Wong, Suvarna Alladi, Lisa Au, Philip M Bath, Geert Jan Biessels, Christopher Chen, Charlotte Cordonnier, Martin Dichgans, Jacqueline Dominguez, Philip B Gorelick, SangYun Kim, Timothy Kwok, Steven M Greenberg, Jianping Jia, Rajesh Kalaria, Miia Kivipelto, Kandiah Naegandran, Linda CW Lam, Bonnie Yin Ka Lam, Allen TC Lee, Hugh S Markus, John O'Brien, Ming-Chyi Pai, Leonardo Pantoni, Perminder Sachdev, Ingmar Skoog, Eric E Smith, Velandai Srikanth, Guk-Hee Suh, Joanna Wardlaw, Ho Ko, Sandra E Black, Philip Scheltens
Jun 18, 2020
We have provided an overview on the profound impact of COVID-19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health-care settings...
Personal protective equipment and intensive care unit healthcare worker safety in the COVID-19 era (PPE-SAFE)
Alexis Tabah, Mahesh Ramanan, Kevin B Laupland, Niccolò Buetti, Andrea Cortegiani, Johannes Mellinghoff, Andrew Conway Morris, Luigi Camporota, Nathalie Zappella, Muhammed Elhadi, Pedro Povoa, Karin Amrein, Gabriela Vidal, Lennie Derde, Matteo Bassetti, Guy Francois, Nathalie Ssi Yan Kai, Jan J De Waele, PPE-SAFE contributors
Jun 18, 2020
PURPOSE: To survey healthcare workers (HCW) on availability and use of personal protective equipment (PPE) caring for COVID-19 patients in the intensive care unit (ICU). MATERIALS AND METHOD: A web-based survey distributed...
covid-19 Health care workers Intensive Care Personal protective equipment Safety Adult Africa Allied Health Personnel Asia Betacoronavirus covid-19 Coronavirus Infections Europe Eye Protective Devices Female Gloves Protective Headache Health Personnel Hot Temperature Humans Infectious Disease Transmission Patient-to-Professional Intensive Care Units Male masks Middle Aged North America Nurses Occupational health Oceania Pandemics Personal Protective Equipment Personnel Staffing and Scheduling Physicians Pneumonia Viral Respiratory Protective Devices SARS-CoV-2 South America Surgical Attire Surveys and Questionnaires Thirst
Caring for patients with cancer in the COVID-19 era.
Joris van de Haar, Louisa R Hoes, Charlotte E Coles, Kenneth Seamon, Stefan Fröhling, Dirk Jäger, Franco Valenza, Filippo de Braud, Luigi De Petris, Jonas Bergh, Ingemar Ernberg, Benjamin Besse, Fabrice Barlesi, Elena Garralda, Alejandro Piris-Giménez, Michael Baumann, Giovanni Apolone, Jean Charles Soria, Josep Tabernero, Carlos Caldas, Emile E Voest
May 13, 2020
The current COVID-19 pandemic challenges oncologists to profoundly re-organize oncological care in order to dramatically reduce hospital visits and admissions and therapy-induced immune-related complications without compromising...
The role of imaging in 2019 novel coronavirus pneumonia (COVID-19).
Wenjing Yang, Arlene Sirajuddin, Xiaochun Zhang, Guanshu Liu, Zhongzhao Teng, Shihua Zhao, Minjie Lu
May 17, 2020
Almost the entire world, not only China, is currently experiencing the outbreak of a novel coronavirus that causes respiratory disease, severe pneumonia, and even death. The outbreak began in Wuhan, China, in December of 2019...
Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.
Harriet CT Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye, Kate N Bishop
Mar 21, 2019
BACKGROUND: Detection of a retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), has recently been reported in 67% of patients with chronic fatigue syndrome. We have studied a total of 170 samples from chronic...
Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease.
Edith L Pfister, Natalie DiNardo, Erica Mondo, Florie Borel, Faith Conroy, Cara Fraser, Gwladys Gernoux, Xin Han, Danjing Hu, Emily Johnson, Lori Kennington, PengPeng Liu, Suzanne J Reid, Ellen Sapp, Petr Vodicka, Tim Kuchel, A Jennifer Morton, David Howland, Richard Moser, Miguel Sena-Esteves, Guangping Gao, Christian Mueller, Marian DiFiglia, Neil Aronin
Sep 20, 2018
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a genetic expansion of the CAG repeat region in the huntingtin (HTT) gene. Studies in HD mouse models have shown that artificial miRNAs can reduce mutant...
AAV Huntington's disease RNAi large animal models Animals Animals Genetically Modified Dependovirus Disease Models Animal Electrolytes Genetic Vectors Genome Viral Humans Huntingtin Protein Huntington Disease Immunoassay Injections Kidney Liver MicroRNAs Microglia Mutant Proteins Neostriatum Neurons RNA Messenger Sheep
Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist.
Lior Soday, Yongxu Lu, Jonas D Albarnaz, Colin TR Davies, Robin Antrobus, Geoffrey L Smith, Michael P Weekes
Apr 16, 2019
Histone deacetylase host-pathogen interaction Immune Evasion innate immunity interferon Poxvirus quantitative proteomics restriction factor systems virology tandem mass tag Cytomegalovirus Down-Regulation Gene Expression Regulation Viral Herpesvirus 1 Human Histone Deacetylases Host-Pathogen Interactions Humans Immune Evasion Interferons Membrane Proteins Proteasome Endopeptidase Complex Proteolysis Proteomics Time Factors Vaccinia vaccinia virus Viral Proteins
Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome.
Agnieszka Szymula, Richard D Palermo, Amr Bayoumy, Ian J Groves, Mohammed Ba Abdullah, Beth Holder, Robert E White
Jul 31, 2018
The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has...
Adult B-Lymphocytes Cell Transformation Viral Cells Cultured Epstein-Barr Virus Infections Female Gene Expression Regulation Viral Genome Viral HEK293 Cells Herpesvirus 4 Human Humans Infant Newborn Leukemia B-Cell Pregnancy Promoter Regions Genetic Protein Binding Transcription Factors Viral Proteins
Collaboration during a crisis - the Lighthouse Lab volunteers.
As a group of early-career researchers, we recount our experiences of volunteering at one of the national Lighthouse Labs based at the UK Biocentre in Milton Keynes. We worked together as part of a multidisciplinary team to...
Snake venom phospholipase A2s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2.
Andrei E Siniavin, Maria A Streltsova, Maria A Nikiforova, Denis S Kudryavtsev, Svetlana D Grinkina, Vladimir A Gushchin, Vera A Mozhaeva, Vladislav G Starkov, Alexey V Osipov, Sarah CR Lummis, Victor I Tsetlin, Yuri N Utkin
Jan 06, 2022
The COVID-19 pandemic caused by SARS-CoV-2 requires new treatments both to alleviate the symptoms and to prevent the spread of this disease. Previous studies demonstrated good antiviral and virucidal activity of phospholipase...
Molecular modelling Pseudotyped SARS-CoV-2 virus Receptor binding domain Replication Cycle Surface Plasmon Resonance Time-of-drug-addition assay Angiotensin-Converting Enzyme 2 Animals Antibody Affinity Antiviral Agents Cell Fusion Cell Line Chlorocebus aethiops Cytopathogenic Effect Viral HEK293 Cells Humans Models Molecular Phospholipases A2 Protein Domains SARS-CoV-2 Spike Glycoprotein Coronavirus Surface Plasmon Resonance Vero Cells Viper Venoms Virus Attachment COVID-19 Drug Treatment
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
Dinesh Aggarwal, Ben Warne, Aminu S Jahun, William L Hamilton, Thomas Fieldman, Louis du Plessis, Verity Hill, Beth Blane, Emmeline Watkins, Elizabeth Wright, Grant Hall, Catherine Ludden, Richard Myers, Myra Hosmillo, Yasmin Chaudhry, Malte L Pinckert, Iliana Georgana, Rhys Izuagbe, Danielle Leek, Olisaeloka Nsonwu, Gareth J Hughes, Simon Packer, Andrew J Page, Marina Metaxaki, Stewart Fuller, Gillian Weale, Jon Holgate, Christopher A Brown, Cambridge Covid-19 testing Centre, University of Cambridge Asymptomatic COVID-19 Screening Programme Consortium, COVID-19 Genomics UK (COG-UK) Consortium, Rob Howes, Duncan McFarlane, Gordon Dougan, Oliver G Pybus, Daniela De Angelis, Patrick H Maxwell, Sharon J Peacock, Michael P Weekes, Chris Illingworth, Ewan M Harrison, Nicholas J Matheson, Ian G Goodfellow
Mar 13, 2022
Rolling circle RNA synthesis catalyzed by RNA.
RNA-catalyzed RNA replication is widely considered a key step in the emergence of life's first genetic system. However, RNA replication can be impeded by the extraordinary stability of duplex RNA products, which must be...
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Phil Palmer, Joanne Marie M Del Rosario, Kelly AS da Costa, George W Carnell, Chloe Q Huang, Jonathan L Heeney, Nigel J Temperton, David A Wells
Mar 30, 2022
The emergence of COVID-19 has emphasised that biological assay data must be analysed quickly to develop safe, effective and timely vaccines/therapeutics. For viruses such as SARS-CoV-2, the primary way of measuring immune...
ELLA SARS-C0V-2 Biological Assay Data analysis dose-response Influenza pseudotype neutralization pseudovirus Antibodies Neutralizing Antibodies Viral covid-19 Data Interpretation Statistical Dose-Response Relationship Drug Humans Immunoassay Influenza A virus Influenza Human Quality Control SARS-CoV-2 Software
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity.
Bo Meng, Adam Abdullahi, Isabella ATM Ferreira, Niluka Goonawardane, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Pehuén Pereyra Gerber, Saman Fatihi, Surabhi Rathore, Samantha K Zepeda, Guido Papa, Steven A Kemp, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Kotaro Shirakawa, Akifumi Takaori-Kondo, Teresa Brevini, Donna L Mallery, Oscar J Charles, CITIID-NIHR BioResource COVID-19 Collaboration, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ecuador-COVID19 Consortium, John E Bowen, Anshu Joshi, Alexandra C Walls, Laurelle Jackson, Darren Martin, Kenneth GC Smith, John Bradley, John AG Briggs, Jinwook Choi, Elo Madissoon, Kerstin B Meyer, Petra Mlcochova, Lourdes Ceron-Gutierrez, Rainer Doffinger, Sarah A Teichmann, Andrew J Fisher, Matteo S Pizzuto, Anna de Marco, Davide Corti, Myra Hosmillo, Joo Hyeon Lee, Leo C James, Lipi Thukral, David Veesler, Alex Sigal, Fotios Sampaziotis, Ian G Goodfellow, Nicholas J Matheson, Kei Sato, Ravindra K Gupta
Mar 31, 2022
The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its...
Adult Aged Aged 80 and over Angiotensin-Converting Enzyme 2 Animals Antibodies Neutralizing Antibodies Viral covid-19 COVID-19 Vaccines Cell Line Cell Membrane Chlorocebus aethiops Convalescence Female Humans Immune Sera Intestines Lung Male Membrane Fusion Middle Aged Mutation Nasal Mucosa SARS-CoV-2 Serine Endopeptidases Spike Glycoprotein Coronavirus Tissue Culture Techniques Virulence Virus Internalization Virus Replication
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