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Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion.
Hemma Brandstaetter, Chieko Kishi-Itakura, David A Tumbarello, Dietmar J Manstein, Folma Buss
Feb 10, 2015
BafA1 bafilomycin A1 EGF epidermal growth factor EGFR epidermal growth factor receptor EM electron microscopy GFP green fluorescent protein KD knockdown LAMP1 lysosomal-associated membrane protein 1 LC3 microtubule-associated protein 1 light chain 3 MVB multivesicular body MYO1C myosin IC PB phosphate buffer PCIP pentachloropseudilin PtdIns(4 5)P2 phosphatidylinositol 4 5-bisphosphate RFP red fluorescent protein RPE retinal pigment epithelium Autophagy Cholesterol Electron microscopy lipid raft lysosome MYO1C Autophagy Cell Line Cell Movement Endocytosis Endosomes Humans Lysosomes Membrane Fusion Membrane Microdomains Myosin Type I Myosins Phagosomes Protein Transport