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Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters
DA Rhodes, Hung-Chang Chen, James C Williamson, Alfred Hill, Jack Yuan, Sam Smith, Harriet Rhodes, John Trowsdale, Paul J Lehner, Thomas Herrmann, Matthias Eberl
Jul 04, 2018
Activation of human Vγ9/Vδ2 T cells by ‘phosphoantigens’ (pAg), the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) and the endogenous isoprenoid intermediate isopentenyl pyrophosphate (IPP)...
1 Underpinning research 1.1 Normal biological development and functioning 2.1 Biological and endogenous factors 2 Aetiology Generic Health Relevance ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter Subfamily G Member 1 ATP Binding Cassette Transporter Subfamily G Member 2 Antigen Presentation Antigens CD Butyrophilins Diphosphates HLA Antigens HeLa Cells Humans Interferon-gamma Lymphocyte Activation Neoplasm Proteins Protein Stability Receptors Antigen T-Cell gamma-delta T-Lymphocytes
Gamma delta T-cell large granular lymphocyte lymphoma in a dog.
Ana Liza Ortiz, Sofia Carvalho, Chiara Leo, Fulvio Riondato, Joy Archer, Francesco Cian
May 26, 2015
IL-7-dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response.
Hung-Chang Chen, Nils Eling, Celia Pilar Martinez-Jimenez, Louise McNeill O'Brien, Valentina Carbonaro, John C Marioni, Duncan T Odom, Maike de la Roche
Jun 03, 2019
IL-7 Ageing lymph node tumour response γδ T-cell lineage aging Animals Carcinoma Lewis Lung Cell Differentiation Cell Lineage Gene Expression Regulation Neoplastic Immunophenotyping Interleukin-17 Interleukin-7 Lymph Nodes Mice Mice Inbred C57BL Receptors Antigen T-Cell gamma-delta Signal Transduction T-Lymphocyte Subsets Tumor Burden
Classification of intestinal T-cell receptor repertoires using machine learning methods can identify patients with coeliac disease regardless of dietary gluten status.
Andrew D Foers, M Saad Shoukat, Oliver E Welsh, Killian Donovan, Russell Petry, Shelley C Evans, Michael Eb FitzPatrick, Nadine Collins, Paul Klenerman, Anna Fowler, Elizabeth J Soilleux
Dec 03, 2020
In coeliac disease (CeD), immune-mediated small intestinal damage is precipitated by gluten, leading to variable symptoms and complications, occasionally including aggressive T-cell lymphoma. Diagnosis, based primarily on...
TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells.
Maria Papadopoulou, Paola Tieppo, Naomi McGovern, Françoise Gosselin, Jerry KY Chan, Glenn Goetgeluk, Nicolas Dauby, Alexandra Cogan, Catherine Donner, Florent Ginhoux, Bart Vandekerckhove, David Vermijlen
Oct 28, 2019
Phosphoantigen-reactive Vγ9Vδ2 T cells represent the main innate human γδ T cell subset and dominate the fetal and adult peripheral blood γδ T cell repertoire. It has been hypothesized that adult blood Vγ9Vδ2 T cells find their...
Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin.
David A Rhodes, Hung-Chang Chen, Amanda J Price, Anthony H Keeble, Martin S Davey, Leo C James, Matthias Eberl, John Trowsdale
Apr 02, 2015
Animals Antigens Antigens CD Binding Sites Butyrophilins COS Cells Cell Line Tumor Chlorocebus aethiops Crystallography X-Ray Diphosphates Diphosphonates Escherichia coli Gene Expression Regulation Hemiterpenes Humans Imidazoles Lymphocyte Activation Membrane Proteins Models Molecular Organophosphorus Compounds Phosphoproteins Plakins Primary Cell Culture Protein Binding Receptors Antigen T-Cell gamma-delta Recombinant Fusion Proteins Signal Transduction T-Lymphocytes Two-Hybrid System Techniques Zoledronic Acid