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Results: 1
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Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice.
Alice P Sowton
,
Nisha Padmanabhan
,
Simon J Tunster
,
Ben D McNally
,
Antonio Murgia
,
Aisha Yusuf
,
Julian L Griffin
,
Andrew J Murray
,
Erica D Watson
Mar 17, 2020
5-methyl-THF
5-methyltetrahydofolate
Agl
amylo-alpha-1
6-glucosidase
4-alpha-glucanotransferase gene
BCA
bicinchoninic acid
Bhmt
betaine-homocysteine S-methyltransferase gene
Ce
cholesteryl-ester
Cebpa
CCAAT/enhancer binding protein (C/EBP)
alpha gene
Cer
ceramide
DAG
diacylglycerol
Ddit3
DNA damage inducible transcript 3 gene
ETS
electron transport system
FCCP
p-trifluoromethoxyphenyl hydrazine
FFA
free fatty acid
G6pc
glucose 6-phophastase gene
Gbe1
glycogen branching enzyme 1 gene
Glycogen
GSK3
glycogen synthase kinase gene
Gyg
glycogenin gene
Gys2
glycogen synthase 2 gene
HOAD
3-hydoxyacyl-CoA dehydrogenase
Hepatic fuel storage
Isca1
iron‑sulfur cluster assembly 1 gene
JO2
oxygen flux
LC-MS
liquid chromatography-mass spectrometry
LPC
lysophosphatidylcholine
lipidomics
Liver metabolism
Mitochondrial function
MTHFR
methylenetetrahydrofolate reductase gene
Mtr
methionine synthase gene (also MS)
MTRR
methionine synthase reductase gene (also MSR)
Myc
myelocytomatosis oncogene
NAFLD
non-alcoholic fatty liver disease
NASH
non-alcoholic steatohepatitis
Ndufs
NADH:ubiquinone oxidoreductase core subunit (ETS complex I) gene
OXPHOS
oxidative phosphorylation
One‑carbon metabolism
PA
phosphatidic acid
PAS
periodic acid Schiff
PC
phosphatidylcholine
PE
phosphatidylethanolamine
PG
phosphatidylglycerol
PI
phosphatidylinositol
PIP
phosphatidylinositol phosphate(s)
PL
phospholipid
PS
phosphatidylserine
RIPA
Radioimmunoprecipitation assay
SAH
S-adenosylhomocysteine
SAM
S-adenosylmethionine
SM
sphingomyelin
TAG
triacylglycerol
Ugp2
UDP-glucose pyrophophorylase 2 gene
gt
gene-trap
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