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The single greatest risk factor for neurodegenerative diseases is aging. Aging of cells such as microglia in the nervous system has an impact not only on the ability of those cells to function but also on cells they interact...

The origin of enzyme catalysis remains a question of debate despite much intense study. We report a QM/MM theoretical study of the S _N2 methyl transfer reaction catalyzed by a glycine N-methyltransferase (GNMT) and...

Basic leucine zipper (bZIP) proteins reside at the end of cell-signaling cascades and function to modulate transcription of specific gene targets. bZIPs are recognized as important regulators of cellular processes such as...

There is now crucial medical importance placed on understanding the role of early stage, subvisible protein aggregation, particularly in neurodegenerative disease. While there are strategies for detecting such aggregates in...

Organ-Chips are micro-engineered systems that aim to recapitulate the organ microenvironment. Implementation of Organ-Chips within the pharmaceutical industry aims to improve the probability of success of drugs reaching late...

Active infrared thermography is a fast and accurate non-destructive evaluation technique that is of particular relevance to the aerospace industry for the inspection of aircraft and helicopters’ primary and secondary...

Reactions of β-diketiminato magnesium and calcium hydrides with 1 atm of CO result in a reductive coupling process to produce the corresponding derivatives of the cis-ethenediolate dianion. Computational (DFT) analysis of...

Voltammetric analysis is often dependent on pH and on the addition of buffer reagents to optimise the analytical procedure. This approach is not always possible for in situ analytical measurements, for example when studying...

The catalytic activities of supported metal nanoparticles can be tuned by appropriate design of synthesis strategies. Each step in a catalyst synthesis method can play an important role in preparing the most efficient...

The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer's disease is increased age. Therefore, understanding the changes that occur as a result of aging is central to any possible prevention...

The role of arginines R64 and R89 at non-annular lipid binding sites of KcsA, on the modulation of channel activity by anionic lipids has been investigated. In wild-type (WT) KcsA reconstituted into asolectin lipid membranes...

A new bio-imaging method has been developed by introducing an experimental verification of capacitively coupled resistivity imaging in a small scale. This paper focuses on the 2D circular array imaging sensor as well as a 3D...

A new bio-imaging method has been developed by introducing an experimental verification of capacitively coupled resistivity imaging in a small scale. This paper focuses on the 2D circular array imaging sensor as well as a 3D...

Transgene-design is a web application to help design transgenes for use in mammalian studies. It is predicated on the recent discovery that human intronless transgenes and native retrogenes can be expressed very effectively...

AzuFluor® 435-DPA-Zn, an azulene fluorophore bearing two zinc(ii)-dipicolylamine receptor motifs, exhibits fluorescence enhancement in the presence of adenosine diphosphate. Selectivity for ADP over ATP, AMP and PPi results...

Photodynamic therapy (PDT) is a promising approach for the targeted treatment of cancer and various other human disorders. An effective, clinically approved approach in PDT involves the administration of 5-aminolevulinic acid...

Aims: Drug-induced liver injury, especially acetaminophen (APAP)-induced liver injury, is a leading cause of liver failure worldwide. Mouse models were used to evaluate the effect of microelement selenium levels on the...