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Results: 37
Energy and Electron Transfer Dynamics within a Series of Perylene Diimide/Cyclophane Systems.
Seán TJ Ryan, Ryan M Young, James J Henkelis, Nema Hafezi, Nicolaas A Vermeulen, Andreas Hennig, Edward J Dale, Yilei Wu, Matthew D Krzyaniak, Athan Fox, Werner M Nau, Michael R Wasielewski, J Fraser Stoddart, Oren A Scherman
Apr 29, 2016
Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking.
Alexander V Strizhak, Krishna Sharma, Oleg Babii, Sergii Afonin, Anne S Ulrich, Igor V Komarov, David R Spring
Dec 04, 2018
Photoisomerizable diarylethenes equipped with triple bonds are promising building blocks for constructing bistable photocontrollable systems. Here we report on the design, synthesis and application of a cross-linking reagent...
Bioinspired Total Synthesis of Bussealin E.
David G Twigg, Leonardo Baldassarre, Elizabeth C Frye, Warren RJD Galloway, David R Spring
Jun 01, 2018
The first total synthesis of bussealin E, a natural product with a unique cycloheptadibenzofuran scaffold, is reported. A strategy inspired by a proposed biosynthesis was employed whereby a diphenylpropane derivative underwent...
Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.
Jessica Iegre, Paul Brear, David J Baker, Yaw Sing Tan, Eleanor L Atkinson, Hannah F Sore, Daniel H O' Donovan, Chandra S Verma, Marko Hyvönen, David R Spring
Apr 26, 2019
The discovery of new Protein-Protein Interaction (PPI) modulators is currently limited by the difficulties associated with the design and synthesis of selective small molecule inhibitors. Peptides are a potential solution for...
Toward the total synthesis of patellazole B
Andrew W Phillips, Matthew J Anketell, Tudor Balan, Nelson YS Lam, Simon Williams, Ian Paterson
Nov 15, 2018
The patellazoles are a family of complex marine macrolides that exhibit potent cytotoxicity against cancer cell lines. However, despite extensive characterisation efforts, their full stereochemical assignment has remained...
Neutron imaging and modelling inclined vortex driven thin films.
The vortex fluidic device (VFD) is a thin film microfluidic platform which has a wide range of applications in synthesis and other areas of science, and it is important to understand the nature of the thin film of liquid in its...
Enabling synthesis in fragment-based drug discovery by reactivity mapping
In fragment-based drug discovery (FBDD), a weakly binding fragment hit is elaborated into a potent ligand by bespoke functionalization along specific directions (growth vectors) from the fragment core in order to complement the...
Probing the chemical structure of monolayer covalent-organic frameworks grown via Schiff-base condensation reactions.
Ya Hu, Niall Goodeal, Ying Chen, Alex M Ganose, Robert G Palgrave, Hugo Bronstein, Matthew O Blunt
Feb 15, 2018
Two-dimensional covalent-organic frameworks (2D-COFs) on surfaces offer a facile route to new 2D materials. Schiff-base condensation reactions have proven to be an effective fabrication route for such materials. We present...
A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A.
As part of our ongoing studies towards the total synthesis of phormidolide A (1), we explored the chelation-controlled vinylmetal addition of iodide 2 to aldehyde 3 to install the reported 17S configuration. While the...
Time dependent decomposition of ammonia borane for the controlled production of 2D hexagonal boron nitride.
Vitaliy Babenko, George Lane, Antal A Koos, Adrian T Murdock, Karwei So, Jude Britton, Seyyed Shayan Meysami, Jonathan Moffat, Nicole Grobert
Jan 24, 2018
Ammonia borane (AB) is among the most promising precursors for the large-scale synthesis of hexagonal boron nitride (h-BN) by chemical vapour deposition (CVD). Its non-toxic and non-flammable properties make AB particularly...
Palladium-catalysed C-H activation of aliphatic amines to give strained nitrogen heterocycles.
The development of new chemical transformations based on catalytic functionalization of unactivated C-H bonds has the potential to simplify the synthesis of complex molecules dramatically. Transition metal catalysis has emerged...
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