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The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension.
Human genetic discoveries offer a powerful method to implicate pathways of major importance to disease pathobiology and hence provide targets for pharmacological intervention. The genetics of pulmonary arterial hypertension...
Heparin-induced thrombocytopaenia presenting as acute aortic mural thrombosis.
Maya Joanne Bienz, Pawel Obrocki, James Russell, Rajesh Jena, Iosif Alexandru Mendichovszky
Jan 21, 2019
Heparin-induced thrombocytopaenia (HIT) is a life and limb-threatening acquired autoimmune complication of heparin-based treatment, characterised by thrombocytopaenia and thrombosis. We present a case of a 77-year-old female...
Emergency endovascular management of peripheral artery aneurysms and pseudoaneurysms - a review.
Umar Sadat, Peter J Kullar, Ayesha Noorani, Jonathan H Gillard, David G Cooper, Jonathan R Boyle
Jun 16, 2011
Non-invasive MR imaging of inflammation in a patient with both asymptomatic carotid atheroma and an abdominal aortic aneurysm
Simon PS Howarth, Tjun Y Tang, Martin J Graves, Jean-Marie U-King-Im, Zhi-Yong Li, Stewart R Walsh, Michael E Gaunt, Jonathan H Gillard
Jun 16, 2011
1103 Clinical Sciences 1102 Cardiorespiratory Medicine and Haematology Biomedical Clinical Medicine and Science aging Diagnostic Radiology Cardiovascular Clinical Research Patient Safety Prevention Atherosclerosis Cardiovascular 4.2 Evaluation of markers and technologies 2.1 Biological and endogenous factors 4.1 Discovery and preclinical testing of markers and technologies
Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.
Oleg Pak, Susan Scheibe, Azadeh Esfandiary, Mareike Gierhardt, Akylbek Sydykov, Angela Logan, Athanasios Fysikopoulos, Florian Veit, Matthias Hecker, Florian Kroschel, Karin Quanz, Alexandra Erb, Katharina Schäfer, Mirja Fassbinder, Nasim Alebrahimdehkordi, Hossein A Ghofrani, Ralph T Schermuly, Ralf P Brandes, Werner Seeger, Michael P Murphy, Norbert Weissmann, Natascha Sommer
Jun 18, 2018
Increased mitochondrial reactive oxygen species (ROS), particularly superoxide have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension (PH) and right ventricular...
Clinical and cost-effectiveness analysis of an open label, single-centre, randomised trial of spinal cord stimulation (SCS) versus percutaneous myocardial laser revascularisation (PMR) in patients with refractory angina pectoris
MT Dyer, KA Goldsmith, SN Khan, LD Sharples, C Freeman, I Hardy, MJ Buxton, PM Schofield
Jun 16, 2011
Would primary healthcare professionals prescribe a polypill to manage cardiovascular risk? A qualitative interview study.
Satnam K Virdee, Sheila M Greenfield, Kate Fletcher, Richard J McManus, FD Richard Hobbs, Jonathan Mant
May 03, 2018
OBJECTIVES: A 'polypill' containing both blood pressure-lowering and cholesterol-lowering drugs could prevent up to 80% of cardiovascular disease events. Since little is known about the attitudes of primary healthcare...
Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
Sanna Vattulainen-Collanus, Mark Southwood, Xu Dong Yang, Stephen Moore, Prajakta Ghatpande, Nicholas W Morrell, Giorgio Lagna, Akiko Hata
Dec 13, 2018
The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary...