Search
Results: 25
Orientation selectivity in a multi-gated organic electrochemical transistor.
Paschalis Gkoupidenis, Dimitrios A Koutsouras, Thomas Lonjaret, Jessamyn A Fairfield, George G Malliaras
Mar 27, 2018
UNLABELLED: Neuromorphic devices offer promising computational paradigms that transcend the limitations of conventional technologies. A prominent example, inspired by the workings of the brain, is spatiotemporal information...
Imaging in the diagnosis and prognosis of traumatic brain injury.
INTRODUCTION: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Improved understanding of the impact of head injury and the extent and development of neuronal loss and cognitive dysfunction could...
1109 Neurosciences Biomedical Clinical Medicine and Science Injury - Childhood Injuries Injury - Trauma - (Head and Spine) Neurosciences Injury - Traumatic brain injury Diagnostic Radiology Pediatric Injury (total) Accidents/Adverse Effects Brain Disorders Neurological Injuries and accidents 4.2 Evaluation of markers and technologies
SORL1 mutations in early- and late-onset Alzheimer disease.
Michael L Cuccaro, Regina M Carney, Yalun Zhang, Christopher Bohm, Brian W Kunkle, Badri N Vardarajan, Patrice L Whitehead, Holly N Cukier, Richard Mayeux, Peter St George-Hyslop, Margaret A Pericak-Vance
Feb 07, 2019
OBJECTIVE: To characterize the clinical and molecular effect of mutations in the sortilin-related receptor (SORL1) gene. METHODS: We performed whole-exome sequencing in early-onset Alzheimer disease (EOAD) and late-onset...
1109 Neurosciences Biomedical Basic Science Human Genome Alzheimer's Disease Clinical Research Dementia Brain Disorders Neurodegenerative aging Genetics Acquired Cognitive Impairment Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Neurological 2.1 Biological and endogenous factors
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD.
Carol A Colton, Ryan T Mott, Hayley Sharpe, Qing Xu, William E Van Nostrand, Michael P Vitek
Aug 10, 2017
BACKGROUND: Microglia are associated with neuritic plaques in Alzheimer disease (AD) and serve as a primary component of the innate immune response in the brain. Neuritic plaques are fibrous deposits composed of the amyloid...
1109 Neurosciences 1107 Immunology Biomedical Basic Science aging Acquired Cognitive Impairment Neurosciences Dementia Genetics Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Alzheimer's Disease Brain Disorders Neurodegenerative Neurological 2.1 Biological and endogenous factors
Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology.
Steve Pedrini, Carlos Thomas, Hannah Brautigam, James Schmeidler, Lap Ho, Paul Fraser, David Westaway, Peter St George Hyslop, Ralph N Martins, Joseph D Buxbaum, Giulio M Pasinetti, Dara L Dickstein, Patrick R Hof, Michelle E Ehrlich, Sam Gandy
Jun 16, 2011
1109 Neurosciences Biomedical Basic Science aging Neurosciences Dementia Neurodegenerative Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Alzheimer's Disease Brain Disorders Nutrition Acquired Cognitive Impairment Neurological 2.1 Biological and endogenous factors 1.1 Normal biological development and functioning
The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration.
Apathy and impulsivity are common and often coexistent consequences of frontotemporal lobar degeneration (FTLD). They increase patient morbidity and carer distress, but remain under-estimated and poorly treated. Recent...
Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo.
John W Steele, Soong H Kim, John R Cirrito, Deborah K Verges, Jessica L Restivo, David Westaway, Paul Fraser, Peter St George Hyslop, Mary Sano, Ilya Bezprozvanny, Michelle E Ehrlich, David M Holtzman, Sam Gandy
Jun 16, 2011
ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology.
Carolin Koriath, Tammaryn Lashley, William Taylor, Ronald Druyeh, Athanasios Dimitriadis, Nicola Denning, Julie Williams, Jason D Warren, Nick C Fox, Jonathan M Schott, James B Rowe, John Collinge, Jonathan D Rohrer, Simon Mead
May 30, 2019
INTRODUCTION: Apolipoprotein E (ApoE) is the most important genetic risk factor for Alzheimer's disease (AD), with ApoE4 thought to enhance and accelerate amyloid-β (Aβ) pathology. ApoE4 has recently been described to increase...
1109 Neurosciences Acquired Cognitive Impairment Dementia Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) frontotemporal dementia (FTD) aging Brain Disorders Neurodegenerative Alzheimer's Disease Alzheimer's Disease Related Dementias (ADRD) Genetics Neurological 2.1 Biological and endogenous factors
A multiple sclerosis-like disorder in patients with OPA1 mutations.
Patrick Yu-Wai-Man, Achillefs Spyropoulos, Holly J Duncan, Joseph V Guadagno, Patrick F Chinnery
Apr 26, 2016
Correction to: The Edinburgh Consensus
Craig W Ritchie, Tom C Russ, Sube Banerjee, Bob Barber, Andrew Boaden, Nick C Fox, Clive Holmes, Jeremy D Isaacs, Ira Leroi, Simon Lovestone, Matt Norton, John O'Brien, Jim Pearson, Richard Perry, James Pickett, Adam D Waldman, Wai Lup Wong, Martin N Rossor, Alistair Burns
Jul 31, 2018
Since the publication of this article [1], it has come to the attention of the authors that information for one of the authors was not included in the competing interests section. Craig Richie has declared potential competing...
Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems
Alzheimer's disease
OBJECTIVE: Peripheral protein biomarkers of Alzheimer's disease (AD) may help identify novel treatment avenues by allowing early diagnosis, recruitment to clinical trials, and treatment initiation. The purpose of this review was...
1109 Neurosciences Biomedical Clinical Medicine and Science aging Neurosciences Dementia Neurodegenerative Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Alzheimer's Disease Brain Disorders Acquired Cognitive Impairment Neurological 4.1 Discovery and preclinical testing of markers and technologies
Overall judgment of loudness of time-varying sounds.
Listeners can judge the overall loudness of time-varying sounds quite easily, i.e., assign a single value that represents the loudness of the entire sound. This holds even if the duration is long and the judgment includes memory...
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
Marija Iljina, Laura Tosatto, Minee L Choi, Jason C Sang, Yu Ye, Craig D Hughes, Clare E Bryant, Sonia Gandhi, David Klenerman
Dec 04, 2017
Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model.
Diptaman Chatterjee, Mansi Bhatt, David Butler, Erwin De Genst, Christopher M Dobson, Anne Messer, Jeffrey H Kordower
Nov 21, 2018
Therapeutics designed to target α-synuclein (α-syn) aggregation may be critical in halting the progression of pathology in Parkinson's disease (PD) patients. Nanobodies are single-domain antibody fragments that bind with...
Long-term neurotoxicity of chemotherapy in adolescents and young adults treated for bone and soft tissue sarcomas.
Epilepsy, cognitive deficits and neuroanatomy in males with ZDHHC9 mutations.
Kate Baker, Duncan E Astle, Gaia Scerif, Jessica Barnes, Jennie Smith, Georgina Moffat, Jonathan Gillard, Torsten Baldeweg, F Lucy Raymond
May 20, 2015
1109 Neurosciences Clinical Clinical Medicine and Science Basic Behavioral and Social Science Neurosciences Neurodegenerative Genetics Clinical Research Intellectual and Developmental Disabilities (IDD) Brain Disorders Behavioral and Social Science Mental Health Epilepsy Neurological Mental Health 2.1 Biological and endogenous factors
E-I balance emerges naturally from continuous Hebbian learning in autonomous neural networks.
Spontaneous brain activity is characterized in part by a balanced asynchronous chaotic state. Cortical recordings show that excitatory (E) and inhibitory (I) drivings in the E-I balanced state are substantially larger than the...
Complicated spastic paraplegia in patients with AP5Z1 mutations (SPG48).
Jennifer Hirst, Marianna Madeo, Katrien Smets, James R Edgar, Ludger Schols, Jun Li, Anna Yarrow, Tine Deconinck, Jonathan Baets, Elisabeth Van Aken, Jan De Bleecker, Manuel B Datiles, Ricardo H Roda, Joachim Liepert, Stephan Züchner, Caterina Mariotti, Peter De Jonghe, Craig Blackstone, Michael C Kruer
Dec 19, 2018
OBJECTIVE: Biallelic mutations in the AP5Z1 gene encoding the AP-5 ζ subunit have been described in a small number of patients with hereditary spastic paraplegia (HSP) (SPG48); we sought to define genotype-phenotype correlations...
Multimodal imaging of brain connectivity reveals predictors of individual decision strategy in statistical learning.
Vasilis M Karlaftis, Joseph Giorgio, Petra E Vértes, Rui Wang, Yuan Shen, Peter Tino, Andrew E Welchman, Zoe Kourtzi
Jan 17, 2019
1701 Psychology 1109 Neurosciences Biomedical Behavioral and Social Science Neurosciences Bioengineering Brain Disorders Basic Behavioral and Social Science Mental Health Neurological 1.2 Psychological and socioeconomic processes 1.1 Normal biological development and functioning 2.3 Psychological social and economic factors