Tissue-Specific Human Extracellular Matrix Scaffolds Promote Pancreatic Tumour Progression and Chemotherapy Resistance.
Walid Al-Akkad,
Pilar Acedo,
Maria-Giovanna Vilia,
Luca Frenguelli,
Alexander Ney,
Irene Rodriguez-Hernandez,
Peter L Labib,
Domenico Tamburrino,
Gabriele Spoletini,
Andrew R Hall,
Simone Canestrari,
Anna Osnato,
Jose Garcia-Bernardo,
Leinal Sejour,
Vessela Vassileva,
Ioannis S Vlachos,
Giuseppe Fusai,
Tu Vinh Luong,
Steven R Whittaker,
Stephen P Pereira,
Ludovic Vallier,
Massimo Pinzani,
Krista Rombouts,
Giuseppe Mazza
Jan 04, 2023
Over 80% of patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed at a late stage and are locally advanced or with concurrent metastases. The aggressive phenotype and relative chemo- and radiotherapeutic resistance...