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Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of...

3D chromatin structure DNA Methylation biological noise Chromatin epigenetics Gene Expression genome architecture Heterogeneity Transcription variability Adaptation Physiological Biological Variation Individual Biological Variation Population Chromatin Epigenesis Genetic genetic variation Humans Precision Medicine Transcription Genetic