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Epac-induced ryanodine receptor type 2 activation inhibits sodium currents in atrial and ventricular murine cardiomyocytes.
Haseeb Valli, Shiraz Ahmad, Sujan Sriharan, Lydia D Dean, Andrew A Grace, Kamalan Jeevaratnam, Hugh R Matthews, Christopher L-H Huang
May 23, 2018
Acute RyR2 activation by exchange protein directly activated by cAMP (Epac) reversibly perturbs myocyte Ca2+ homeostasis, slows myocardial action potential conduction, and exerts pro-arrhythmic effects. Loose patch-clamp...
8-(4-chlorophenylthio)-2′-O-methyladenosine-3′ 5′-cyclic monophosphate Ca2+ homeostasis Epac Na+ current arrhythmic substrate conduction velocity dantrolene ryanodine receptor Action Potentials Animals Calcium Cyclic AMP Dantrolene Gene Expression Regulation Guanine Nucleotide Exchange Factors Heart Mice Mice Inbred C57BL Microelectrodes Muscle Relaxants Central Myocytes Cardiac Patch-Clamp Techniques Ryanodine Receptor Calcium Release Channel Sodium Channels