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Efficient mitochondrial function is required in tissues with high energy demand such as the heart, and mitochondrial dysfunction is associated with cardiovascular disease. Expression of mitochondrial proteins is tightly...

cardiac Cell Biology human Mitochondria MOUSE protein translation ribosome 5' Untranslated Regions A549 Cells Animals Base Composition Cardiomyopathies Embryo Mammalian Female Humans Male Methyltransferases Mice Mitochondria Mitochondrial Proteins Myocytes Cardiac Protein Interaction Maps Ribosomes

A549 Cells Adaptor Proteins Signal Transducing Adolescent Adult Aged Case-Control Studies Cells Cultured Child Female Genetic Association Studies Genetic Predisposition to Disease HEK293 Cells Hearing Loss Humans Male Middle Aged Mutation Pedigree Polymorphism Single Nucleotide Syndrome Thrombocytopenia Young Adult

Influenza virus-infected cells vary widely in their expression of viral genes and only occasionally activate innate immunity. Here, we develop a new method to assess how the genetic variation in viral populations contributes to...

10x Chromium NS1 PB1 PacBio defective virus Heterogeneity Influenza virus interferon Single-cell RNA-seq A549 Cells genetic variation Humans Immunity Innate Influenza A virus H1N1 Subtype Sequence Analysis RNA Single-Cell Analysis Viral Nonstructural Proteins

A549 Cells Alleles Animals Birds Cell Line Cell Line Tumor Dogs HEK293 Cells Host Specificity Humans Influenza A virus H1N1 Subtype Influenza A virus H3N2 Subtype Influenza in Birds Influenza Human Madin Darby Canine Kidney Cells Mammals Mice Mice Inbred BALB C Orthomyxoviridae Infections Phylogeny Reassortant Viruses Viral Proteins Virulence Virus Replication

BACKGROUND: Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types differ in their...

Cancer Cryptic transcripts DNA Methylation HIF Hypoxia Immunotherapy Transcription factor binding A549 Cells Basic Helix-Loop-Helix Transcription Factors DNA Methylation Humans Hypoxia Hypoxia-Inducible Factor 1 Immune Tolerance MCF-7 Cells Tumor Escape

A549 Cells Animals Biomarkers Tumor Cell Cycle Cell Division Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Focal Adhesion Protein-Tyrosine Kinases Heterografts Humans Mice Proto-Oncogene Mas Proto-Oncogene Proteins c-met

Live cell Raman micro-spectroscopy is emerging as a promising bioanalytical technique for label-free discrimination of a range of different cell types (e.g. cancer cells and fibroblasts) and behaviors (e.g. apoptosis). The aim...

A549 Cells Bronchi Carcinogenesis Cell Culture Techniques Cell Line Cell Proliferation Coculture Techniques Epithelial Cells FIBROBLASTS Humans Lung Lung Neoplasms Sensitivity and Specificity Spectrum Analysis Raman

TAp73 is a transcription factor that plays key roles in brain development, aging, and cancer. At the cellular level, TAp73 is a critical homeostasis-maintaining factor, particularly following oxidative stress. Although major...

ROS TAp73 Mitochondria p53 family Translation A549 Cells HEK293 Cells Humans Mitochondria Oxidative Stress Protein Biosynthesis Reactive Oxygen Species TOR Serine-Threonine Kinases Tumor Protein p73

Deubiquitylases (DUBs) regulate critical signaling pathways at the intersection of host immunity and viral pathogenesis. Although RIG-I activation is heavily dependent on ubiquitylation, systematic analyses of DUBs that regulate...

RIG-I signaling RNA virus deubiquitylases influenza A Innate immune response Ubiquitylation viral subversion strategies A549 Cells Animals Cysteine Endopeptidases Cytosol DEAD Box Protein 58 Deubiquitinating Enzymes Dogs Gene Deletion HEK293 Cells Humans Influenza Human Interferon Regulatory Factor-3 Interferon Type I Madin Darby Canine Kidney Cells Male Mitochondrial Membranes NF-kappa B Proteasome Endopeptidase Complex Protein Multimerization Proteolysis Receptors Immunologic Signal Transduction Viral Nonstructural Proteins

A549 Cells Animals Caenorhabditis elegans Humans Immunity Innate RNA Interference RNA Nucleotidyltransferases RNA Viruses RNA Viral Transcriptome Virus Replication

The poly (ADP-ribose) polymerase (PARP) inhibitor olaparib is FDA approved for the treatment of BRCA-mutated breast, ovarian and pancreatic cancers. Olaparib inhibits PARP1/2 enzymatic activity and traps PARP1 on DNA at...

A549 Cells Animals Ataxia Telangiectasia Mutated Proteins Cell Death Cell Line Cell Line Tumor Chromosome Aberrations Drug Synergism Genomic Instability Humans Indoles Mice Morpholines Phthalazines Piperazines Poly(ADP-ribose) Polymerase Inhibitors Pyrimidines Sulfonamides Sulfoxides

Influenza B viruses (IBV) cause respiratory disease epidemics in humans and are therefore components of seasonal influenza vaccines. Serological methods are employed to evaluate vaccine immunogenicity prior to licensure....

Influenza B lentiviral (LV) vector pseudotype neutralization pseudotype viral particles serosurveillance A549 Cells Animals Antibodies Monoclonal Antibodies Neutralizing Antibodies Viral Antibody Specificity Dogs Genetic Vectors HEK293 Cells Hemagglutinin Glycoproteins Influenza Virus Humans Immunogenicity Vaccine Influenza B virus Influenza Vaccines Influenza Human Lentivirus Madin Darby Canine Kidney Cells Neutralization Tests Orthomyxoviridae Infections Vaccination Vaccine Potency

Novel symmetrical bis-pyrrolo[2,3-d]pyrimidines and bis-purines and their monomers were synthesized and evaluated for their antiproliferative activity in human lung adenocarcinoma (A549), cervical carcinoma (HeLa), ductal...

DFT calculations antiproliferative activity Apoptosis pancreatic adenocarcinoma purine pyrrolo[2 3-d]pyrimidines ULTRASOUND A549 Cells Antineoplastic Agents Cell Line Tumor Cell Proliferation Cell Survival Cycloaddition Reaction density functional theory Drug Screening Assays Antitumor HeLa Cells Humans Pyrimidines Pyrroles

7-methylguanosine (m7G) is present at mRNA caps and at defined internal positions within tRNAs and rRNAs. However, its detection within low-abundance mRNAs and microRNAs (miRNAs) has been hampered by a lack of sensitive...

7-methylguanosine G-Quadruplexes METTL1 RNA methylation SAM-dependent methyltransferase cell migration high-throughput sequencing let-7 miRNA biogenesis microRNA A549 Cells Base Sequence Biological Assay Caco-2 Cells Cell Movement Cell Proliferation Guanosine HEK293 Cells Humans Methylation Methyltransferases MicroRNAs Nucleic Acid Conformation RNA processing Post-Transcriptional