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Cover Image for Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort. View Article
Association between a functional interleukin 6 receptor genetic variant and risk of depression and psychosis in a population-based birth cohort.
Golam M Khandaker, Stanley Zammit, Stephen Burgess, Glyn Lewis, Peter B Jones
Feb 13, 2018
OBJECTIVE: Interleukin 6 (IL-6) levels are commonly elevated in patients with depression and psychosis and in people who are at risk of developing these disorders. A common, functional variant in the IL6R gene (IL6R Asp358Ala;...
ALSPAC birth cohort Asp358Ala Depression IL-6 IL6R immunopsychiatry Inflammation interleukin 6 interleukin 6 receptor Interleukin 6 receptor gene Mendelian randomization Psychosis rs2228145 Adolescent C-Reactive Protein Child Cohort Studies Depressive Disorder Female Genetic Predisposition to Disease Genotype Humans Interleukin-6 Male Polymorphism Single Nucleotide Psychotic Disorders Receptors Interleukin-6
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