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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, OM Dovey, A Mupo, V Grinkevich, M Li, M Mazan, M Gozdecka, S Ohnishi, J Cooper, M Patel, T McKerrell, B Chen, AF Domingues, P Gallipoli, S Teichmann, H Ponstingl, U McDermott, J Saez-Rodriguez, BJP Huntly, F Iorio, C Pina, GS Vassiliou, K Yusa
Dec 05, 2016
Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia.
Haematopoietic stem cells (HSC) are situated at the apex of the haematopoietic differentiation hierarchy, ensuring the life-long supply of mature haematopoietic cells and forming a reservoir to replenish the haematopoietic...
Evi1 Counteracts Anti-Leukemic and Stem Cell Inhibitory Effects of All-Trans Retinoic Acid on Flt3-ITD/Npm1c-Driven Acute Myeloid Leukemia Cells.
Chi Huu Nguyen, Alexander M Grandits, George S Vassiliou, Philipp B Staber, Gerwin Heller, Rotraud Wieser
Oct 19, 2020
All-trans retinoic acid (atRA) has a dramatic impact on the survival of patients with acute promyelocytic leukemia, but its therapeutic value in other types of acute myeloid leukemia (AML) has so far remained unclear. Given that...
Viewing AML through a New Lens
Epigenetic modifications, such as histone modifications and DNA methylation, are essential for ensuring the dynamic control of gene regulation in every cell type. These modifications are associated with gene activation or...