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Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues.
Laurel C Chandler, Alun R Barnard, Sarah L Caddy, Maria I Patrício, Michelle E McClements, Howell Fu, Cristina Rada, Robert E MacLaren, Kanmin Xue
Aug 12, 2020
The therapeutic effects of gene therapy using adeno-associated virus (AAV) vectors are dependent on the efficacy of viral transduction. Currently, we have reached the safe limits of AAV vector dose, beyond which damaging...