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Estrogen Enhances the Expression of the Multidrug Transporter Gene ABCG2-Increasing Drug Resistance of Breast Cancer Cells through Estrogen Receptors.
Fung-Wei Chang, Hueng-Chuen Fan, Jui-Ming Liu, Tai-Ping Fan, Jin Jing, Chia-Ling Yang, Ren-Jun Hsu
Mar 22, 2018
BACKGROUND: Multidrug resistance is a major obstacle in the successful therapy of breast cancer. Studies have proved that this kind of drug resistance happens in both human cancers and cultured cancer cell lines. Understanding...
ATP-binding cassette sub-family G member 2 (ABCG2) Breast Cancer Estrogen estrogen receptor α (ERα) mitoxantrone (MX) ATP Binding Cassette Transporter Subfamily G Member 2 Adenosine Triphosphate Breast Neoplasms Cell Death Cell Hypoxia Drug Resistance Neoplasm Estrogens Female Gene Expression Regulation Neoplastic Genes Mitochondrial Humans MCF-7 Cells Models Biological Oligonucleotide Array Sequence Analysis Reactive Oxygen Species Receptors Estrogen