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Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS)
Philip M Bath, Lisa J Woodhouse, Jason P Appleton, Maia Beridze, Hanne Christensen, Robert A Dineen, Lelia Duley, Timothy J England, Katie Flaherty, Diane Havard, Stan Heptinstall, Marilyn James, Kailash Krishnan, Hugh S Markus, Alan A Montgomery, Stuart J Pocock, Marc Randall, Annemarei Ranta, Thompson G Robinson, Polly Scutt, Graham S Venables, Nikola Sprigg, TARDIS Investigators
Mar 07, 2018
BACKGROUND: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy...
Acute Disease Aged Aspirin Brain Ischemia Clopidogrel Denmark Dipyridamole Drug Therapy Combination Female Georgia Hemorrhage Humans Ischemia Ischemic Attack Transient Male Middle Aged New Zealand Platelet Aggregation Inhibitors Prospective Studies Recurrence Research Design Risk Assessment stroke Thrombolytic Therapy Ticlopidine Treatment Outcome United Kingdom
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.
Pranvera Sadiku, Joseph A Willson, Rebecca S Dickinson, Fiona Murphy, Alison J Harris, Amy Lewis, David Sammut, Ananda S Mirchandani, Eilise Ryan, Emily R Watts, AA Roger Thompson, Helen M Marriott, David H Dockrell, Cormac T Taylor, Martin Schneider, Patrick H Maxwell, Edwin R Chilvers, Massimilliano Mazzone, Veronica Moral, Chris W Pugh, Peter J Ratcliffe, Christopher J Schofield, Bart Ghesquiere, Peter Carmeliet, Moira Kb Whyte, Sarah R Walmsley
Apr 05, 2018
2019 WSES guidelines for the management of severe acute pancreatitis.
Ari Leppäniemi, Matti Tolonen, Antonio Tarasconi, Helmut Segovia-Lohse, Emiliano Gamberini, Andrew W Kirkpatrick, Chad G Ball, Neil Parry, Massimo Sartelli, Daan Wolbrink, Harry Van Goor, Gianluca Baiocchi, Luca Ansaloni, Walter Biffl, Federico Coccolini, Salomone Di Saverio, Yoram Kluger, Ernest Moore, Fausto Catena
Jun 12, 2020
Although most patients with acute pancreatitis have the mild form of the disease, about 20-30% develops a severe form, often associated with single or multiple organ dysfunction requiring intensive care. Identifying the severe...
Cohort profile of the Biomarkers of Acute Serious Illness in Children (BASIC) study
Yael Feinstein, Jennifer Claire Walker, Mark J Peters, Simon Nadel, Nazima Pathan, Naomi Edmonds, Jethro Herberg, Myrsini Kaforou, Victoria Wright, Michael Levin, Padmanabhan Ramnarayan
Dec 12, 2018
Biomarkers children multi-omics retreival Acute Disease Adolescent Bacterial Infections Biomarkers Child Child Preschool Cohort Studies Critical Care Critical Illness Emergency Medical Services England Female Follow-Up Studies Humans Infant Infant Newborn Male Multiple Organ Failure Prospective Studies
Stress Hyperglycemia Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis.
Xinmin Yang, Ruwen Zhang, Tao Jin, Ping Zhu, Linbo Yao, Lan Li, Wenhao Cai, Rajarshi Mukherjee, Dan Du, Xianghui Fu, Jing Xue, Reynaldo Martina, Tingting Liu, Sayali Pendharkar, Anthony R Phillips, Vikesh K Singh, Robert Sutton, John A Windsor, Lihui Deng, Qing Xia, Wei Huang
May 27, 2022
BACKGROUND/AIMS: Stress hyperglycemia is common in critical illness but it has not been clearly studied in patients with acute pancreatitis (AP). This study aimed to investigate the specific blood glucose (BG) level that defines...
The diagnostic accuracy of the natriuretic peptides in heart failure
Emmert Roberts, Andrew J Ludman, Katharina Dworzynski, Abdallah Al-Mohammad, Martin R Cowie, John JV McMurray, Jonathan Mant, NICE Guideline Development Group for Acute Heart Failure
May 02, 2018
OBJECTIVES: To determine and compare the diagnostic accuracy of serum natriuretic peptide levels (B type natriuretic peptide, N terminal probrain natriuretic peptide (NTproBNP), and mid-regional proatrial natriuretic peptide...
Clinical frailty adds to acute illness severity in predicting mortality in hospitalized older adults
Frail Elderly hospital medicine Mortality Patient acuity Survival Analysis Acute Disease Aged Aged 80 and over Emergency Service hospital England Female Frail Elderly Geriatric Assessment Hospital Mortality Humans Length of Stay Male Proportional Hazards Models Retrospective Studies Severity of Illness Index
Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic
Shahida Din, Alexandra Kent, Richard C Pollok, Susanna Meade, Nicholas A Kennedy, Ian Arnott, R Mark Beattie, Felix Chua, Rachel Cooney, Robin J Dart, James Galloway, Daniel R Gaya, Subrata Ghosh, Mark Griffiths, Laura Hancock, Richard Hansen, Ailsa Hart, Christopher Andrew Lamb, Charlie W Lees, Jimmy K Limdi, James O Lindsay, Kamal Patel, Nick Powell, Charles D Murray, Chris Probert, Tim Raine, Christian Selinger, Shaji Sebastian, Philip J Smith, Phil Tozer, Andrew Ustianowski, Lisa Younge, Mark A Samaan, Peter M Irving
Jun 29, 2020
OBJECTIVE: Management of acute severe UC (ASUC) during the novel COVID-19 pandemic presents significant dilemmas. We aimed to provide COVID-19-specific guidance using current British Society of Gastroenterology (BSG) guidelines...
Retrospective analysis assessing the spatial and temporal distribution of paediatric acute respiratory tract infections in Ho Chi Minh City, Vietnam.
Nhan Thi Ho, Corinne Thompson, Le Nguyen Thanh Nhan, Hoang Minh Tu Van, Nguyen Thanh Dung, Phuc Tran My, Vo Minh Quang, Ngo Ngoc Quang Minh, Tran Anh Tuan, Nguyen Thanh Hung, Ha Manh Tuan, Nguyen Van Vinh Chau, Marcel Wolbers, Guy E Thwaites, Marc Choisy, Stephen Baker
Apr 10, 2019
BACKGROUND: Acute respiratory tract infections (ARIs) are the leading cause of morbidity and mortality in young children in low/middle-income countries. Using routine hospital data, we aimed to examine the spatial distribution...
acute respiratory infections lower respiratory infections Pediatrics spatial distribution Temporal patterns upper respiratory infections Acute Disease Adolescent Child Child Preschool Female Hospitalization Hospitals Pediatric Humans Incidence Infant Infant Newborn Male Respiratory Tract Infections Retrospective Studies Risk Factors Seasons Spatio-Temporal Analysis Vietnam weather
Variation in quality of acute stroke care by day and time of admission
Mariya Melnychuk, Stephen Morris, Georgia Black, Angus IG Ramsay, Jeannie Eng, Anthony Rudd, Abigail Baim-Lance, Martin M Brown, Naomi J Fulop, Robert Simister
Sep 14, 2020
OBJECTIVE: To investigate variations in quality of acute stroke care and outcomes by day and time of admission in London hyperacute stroke units compared with the rest of England. DESIGN: Prospective cohort study using...
The stability of care preferences following acute illness
BACKGROUND: Patient preferences are integral to person-centred care, but preference stability is poorly understood in older people, who may experience fluctuant illness trajectories with episodes of acute illness. We aimed to...
Finding a 'new normal' following acute illness
Simon Noah Etkind, Natasha Lovell, Caroline Jane Nicholson, Irene J Higginson, Fliss Em Murtagh
Nov 26, 2020
Appraising the causal role of smoking in multiple diseases
BACKGROUND: The causal association between cigarette smoking and several diseases remains equivocal. The purpose of this study was to appraise the causal role of smoking in a wide range of diseases by summarizing the evidence...
Characterization of healing following atherosclerotic carotid plaque rupture in acutely symptomatic patients
Zhongzhao Teng, Andrew J Degnan, Umar Sadat, Fang Wang, Victoria E Young, Martin J Graves, Shengyong Chen, Jonathan H Gillard
Nov 15, 2011
Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.
Malick M Gibani, Elizabeth Jones, Amber Barton, Celina Jin, Juliette Meek, Susana Camara, Ushma Galal, Eva Heinz, Yael Rosenberg-Hasson, Gerlinde Obermoser, Claire Jones, Danielle Campbell, Charlotte Black, Helena Thomaides-Brears, Christopher Darlow, Christina Dold, Laura Silva-Reyes, Luke Blackwell, Maria Lara-Tejero, Xuyao Jiao, Gabrielle Stack, Christoph J Blohmke, Jennifer Hill, Brian Angus, Gordon Dougan, Jorge Galán, Andrew J Pollard
Jul 02, 2020
Salmonella Typhi is a human host-restricted pathogen that is responsible for typhoid fever in approximately 10.9 million people annually1. The typhoid toxin is postulated to have a central role in disease pathogenesis, the...
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.
Dimitrios Papaioannou, Andreas Petri, Oliver M Dovey, Sara Terreri, Eric Wang, Frances A Collins, Lauren A Woodward, Allison E Walker, Deedra Nicolet, Felice Pepe, Prasanthi Kumchala, Marius Bill, Christopher J Walker, Malith Karunasiri, Krzysztof Mrózek, Miranda L Gardner, Virginia Camilotto, Nina Zitzer, Jonathan L Cooper, Xiongwei Cai, Xiaoqing Rong-Mullins, Jessica Kohlschmidt, Kellie J Archer, Michael A Freitas, Yi Zheng, Robert J Lee, Iannis Aifantis, George Vassiliou, Guramrit Singh, Sakari Kauppinen, Clara D Bloomfield, Adrienne M Dorrance, Ramiro Garzon
Dec 09, 2019
Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated...
Acute Disease Animals Cell Line Tumor Cell Proliferation HEK293 Cells Humans K562 Cells Leukemia Myeloid Mice Inbred NOD Mice Knockout Mice SCID Mutation Nuclear Proteins Nucleophosmin Protein Biosynthesis RNA Long Noncoding RNA Ribosomal THP-1 Cells Transcription Genetic Transplantation Heterologous
Predicting the Individual Risk of Acute Severe Colitis at Diagnosis.
Monica Cesarini, Gary S Collins, Anders Rönnblom, Antonieta Santos, Lai Mun Wang, Daniel Sjöberg, Miles Parkes, Satish Keshav, Simon PL Travis
Mar 19, 2019
BACKGROUND AND AIMS: Acute severe colitis [ASC] is associated with major morbidity. We aimed to develop and externally validate an index that predicted ASC within 3 years of diagnosis. METHODS: The development cohort included...
Biomarkers acute severe colitis Clinical Trials PREDICTION Ulcerative colitis Acute Disease Adult Age Factors C-Reactive Protein Colitis Ulcerative Colonoscopy Disease Progression Female Hemoglobins Hospitalization Humans Male Middle Aged Nomograms Predictive Value of Tests Risk Factors Severity of Illness Index Sex Factors
Effectiveness of a quality improvement collaborative in reducing time to surgery for patients requiring emergency cholecystectomy.
JR Bamber, TJ Stephens, DA Cromwell, E Duncan, GP Martin, NF Quiney, JF Abercrombie, IJ Beckingham, Cholecystectomy Quality Improvement Collaborative
Oct 11, 2019
BACKGROUND: Acute gallstone disease is a high-volume emergency general surgery presentation with wide variations in the quality of care provided across the UK. This controlled cohort evaluation assessed whether participation in...
Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers.
Richard Rubenstein, Binggong Chang, John K Yue, Allen Chiu, Ethan A Winkler, Ava M Puccio, Ramon Diaz-Arrastia, Esther L Yuh, Pratik Mukherjee, Alex B Valadka, Wayne A Gordon, David O Okonkwo, Peter Davies, Sanjeev Agarwal, Fan Lin, George Sarkis, Hamad Yadikar, Zhihui Yang, Geoffrey T Manley, Kevin KW Wang, and the TRACK-TBI Investigators, Shelly R Cooper, Kristen Dams-O'Connor, Allison J Borrasso, Tomoo Inoue, Andrew IR Maas, David K Menon, David M Schnyer, Mary J Vassar
Jul 19, 2018
Direct targeted therapy for MLL-fusion-driven high-risk acute leukaemias.
Sandra Cantilena, Luca Gasparoli, Deepali Pal, Olaf Heidenreich, Jan-Henning Klusmann, Joost HA Martens, Alexandre Faille, Alan J Warren, Mawar Karsa, Ruby Pandher, Klaartje Somers, Owen Williams, Jasper de Boer
Jul 22, 2022
BACKGROUND: Improving the poor prognosis of infant leukaemias remains an unmet clinical need. This disease is a prototypical fusion oncoprotein-driven paediatric cancer, with MLL (KMT2A)-fusions present in most cases. Direct...
Differential prevalence and geographic distribution of hepatitis C virus genotypes in acute and chronic hepatitis C patients in Vietnam.
Chau Le Ngoc, Thanh Tran Thi Thanh, Phuong Tran Thi Lan, Trinh Nguyen Mai, Trang Nguyen Hoa, Ngoc Nghiem My, Tan Le Van, Hung Le Manh, Phuong Le Thanh, Chau Nguyen Van Vinh, Guy Thwaites, Graham Cooke, Gabrielle M Heilek, Cecilia Shikuma, Thuy Le, Stephen Baker, Motiur Rahman, VIZIONS consortium
Apr 10, 2019
BACKGROUND: The highest burden of disease from hepatitis C virus (HCV) is found in Southeast Asia, but our understanding of the epidemiology of infection in many heavily burdened countries is still limited. In particular, there...
Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.
Shu Mei Teo, Howard HF Tang, Danny Mok, Louise M Judd, Stephen C Watts, Kym Pham, Barbara J Holt, Merci Kusel, Michael Serralha, Niamh Troy, Yury A Bochkov, Kristine Grindle, Robert F Lemanske, Sebastian L Johnston, James E Gern, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Nov 12, 2018
Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children. In this study, the occurrence of acute respiratory tract illnesses (ARIs) and the...
airway microbiota allergic sensitization Asthma lower respiratory infection Acute Disease Asthma Child Preschool Cohort Studies Disease Susceptibility Female Humans Hypersensitivity Immunoglobulin E Infant Longitudinal Studies Male Microbiota nasopharynx Prospective Studies Respiratory Sounds Respiratory Tract Infections Risk Factors
The Management of Acute Colonic Diverticulitis in the COVID-19 Era
Roberto Cirocchi, Riccardo Nascimbeni, Gloria Burini, Carlo Boselli, Francesco Barberini, Justin Davies, Salomone Di Saverio, Diletta Cassini, Bruno Amato, Gian Andrea Binda, Gabrio Bassotti
Jan 06, 2022
Background and Objective: During the COVID-19 pandemic, health systems worldwide made major changes to their organization, delaying diagnosis and treatment across a broad spectrum of pathologies. Concerning surgery, there was an...
Diagnosis and treatment of acute appendicitis
Salomone Di Saverio, Mauro Podda, Belinda De Simone, Marco Ceresoli, Goran Augustin, Alice Gori, Marja Boermeester, Massimo Sartelli, Federico Coccolini, Antonio Tarasconi, Nicola De' Angelis, Dieter G Weber, Matti Tolonen, Arianna Birindelli, Walter Biffl, Ernest E Moore, Michael Kelly, Kjetil Soreide, Jeffry Kashuk, Richard Ten Broek, Carlos Augusto Gomes, Michael Sugrue, Richard Justin Davies, Dimitrios Damaskos, Ari Leppäniemi, Andrew Kirkpatrick, Andrew B Peitzman, Gustavo P Fraga, Ronald V Maier, Raul Coimbra, Massimo Chiarugi, Gabriele Sganga, Adolfo Pisanu, Gian Luigi De' Angelis, Edward Tan, Harry Van Goor, Francesco Pata, Isidoro Di Carlo, Osvaldo Chiara, Andrey Litvin, Fabio C Campanile, Boris Sakakushev, Gia Tomadze, Zaza Demetrashvili, Rifat Latifi, Fakri Abu-Zidan, Oreste Romeo, Helmut Segovia-Lohse, Gianluca Baiocchi, David Costa, Sandro Rizoli, Zsolt J Balogh, Cino Bendinelli, Thomas Scalea, Rao Ivatury, George Velmahos, Roland Andersson, Yoram Kluger, Luca Ansaloni, Fausto Catena
Apr 15, 2021
BACKGROUND AND AIMS: Acute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and...
acute appendicitis Adult Appendicitis Score Alvarado score Antibiotics Appendectomy Appendiceal abscess Appendicitis diagnosis score Appendicitis guidelines CT scan appendicitis Complicated appendicitis Consensus conference Diagnostic laparoscopy Imaging Jerusalem guidelines Laparoscopic appendectomy non-operative management Phlegmon Abdominal Pain Acute Disease Anti-Bacterial Agents Appendectomy Appendicitis Evidence-Based Medicine Humans laparoscopy Practice Guidelines as Topic
2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting.
Massimo Sartelli, Dieter G Weber, Yoram Kluger, Luca Ansaloni, Federico Coccolini, Fikri Abu-Zidan, Goran Augustin, Offir Ben-Ishay, Walter L Biffl, Konstantinos Bouliaris, Rodolfo Catena, Marco Ceresoli, Osvaldo Chiara, Massimo Chiarugi, Raul Coimbra, Francesco Cortese, Yunfeng Cui, Dimitris Damaskos, Gian Luigi De' Angelis, Samir Delibegovic, Zaza Demetrashvili, Belinda De Simone, Francesco Di Marzo, Salomone Di Saverio, Therese M Duane, Mario Paulo Faro, Gustavo P Fraga, George Gkiokas, Carlos Augusto Gomes, Timothy C Hardcastle, Andreas Hecker, Aleksandar Karamarkovic, Jeffry Kashuk, Vladimir Khokha, Andrew W Kirkpatrick, Kenneth YY Kok, Kenji Inaba, Arda Isik, Francesco M Labricciosa, Rifat Latifi, Ari Leppäniemi, Andrey Litvin, John E Mazuski, Ronald V Maier, Sanjay Marwah, Michael McFarlane, Ernest E Moore, Frederick A Moore, Ionut Negoi, Leonardo Pagani, Kemal Rasa, Ines Rubio-Perez, Boris Sakakushev, Norio Sato, Gabriele Sganga, Walter Siquini, Antonio Tarasconi, Matti Tolonen, Jan Ulrych, Sannop K Zachariah, Fausto Catena
May 07, 2021
Acute colonic diverticulitis is one of the most common clinical conditions encountered by surgeons in the acute setting. An international multidisciplinary panel of experts from the World Society of Emergency Surgery (WSES)...
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