Search

Bayesian methods closed testing Multiple comparisons response-adaptive randomization Type I error Adaptive Clinical Trials as Topic Bias Computer Simulation Humans Hypercholesterolemia Models Statistical Random Allocation Research Design

Adaptive Clinical Trials as Topic Clinical Trials Phase II as Topic Cohort Studies Computer Simulation Humans Medical Oncology Neoplasms Non-Randomized Controlled Trials as Topic Research Design Sample Size Treatment Outcome

We propose a novel response-adaptive randomization procedure for multi-armed trials with continuous outcomes that are assumed to be normally distributed. Our proposed rule is non-myopic, and oriented toward a patient benefit...

Gittins index adaptive designs continuous endpoint dichotomization missing data unknown variance Adaptive Clinical Trials as Topic Algorithms Biometry Clinical Trials Phase II as Topic Computer Simulation Endpoint Determination Humans Models Statistical Neoplasms Patient Dropouts Randomized Controlled Trials as Topic Treatment Outcome

Multiarm clinical trials, which compare several experimental treatments against control, are frequently recommended due to their efficiency gain. In practise, all potential treatments may not be ready to be tested in a phase...

adding-arm disjunctive power multiarm number of rejected hypotheses Adaptive Clinical Trials as Topic Biostatistics Clinical Protocols Controlled Clinical Trials as Topic Cryotherapy decision theory Humans Multivariate Analysis Nerve Block Osteoarthritis Knee