Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Felix A Dingler,
Meng Wang,
Anfeng Mu,
Christopher L Millington,
Nina Oberbeck,
Sam Watcham,
Lucas B Pontel,
Ashley N Kamimae-Lanning,
Frederic Langevin,
Camille Nadler,
Rebecca L Cordell,
Paul S Monks,
Rui Yu,
Nicola K Wilson,
Asuka Hira,
Kenichi Yoshida,
Minako Mori,
Yusuke Okamoto,
Yusuke Okuno,
Hideki Muramatsu,
Yuichi Shiraishi,
Masayuki Kobayashi,
Toshinori Moriguchi,
Tomoo Osumi,
Motohiro Kato,
Satoru Miyano,
Etsuro Ito,
Seiji Kojima,
Hiromasa Yabe,
Miharu Yabe,
Keitaro Matsuo,
Seishi Ogawa,
Berthold Göttgens,
Michael RG Hodskinson,
Minoru Takata,
Ketan J Patel
Nov 06, 2020
Reactive aldehydes arise as by-products of metabolism and are normally cleared by multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, mitochondrial ALDH2 and cytoplasmic ADH5, have greatly...