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Peptide-targeted dendrimeric prodrugs of 5-aminolevulinic acid
Photodynamic therapy (PDT) is a promising approach for the targeted treatment of cancer and various other human disorders. An effective, clinically approved approach in PDT involves the administration of 5-aminolevulinic acid...
Aminolevulinic Acid click chemistry Fluorescence diagnosis Peptide Photodynamic therapy prodrug protoporphyrin IX /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Glycolysis inhibition improves photodynamic therapy response rates for equine sarcoids.
Photodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to...
A Neural Network Approach to Identify the Peritumoral Invasive Areas in Glioblastoma Patients by Using MR Radiomics.
Jiun-Lin Yan, Chao Li, Anouk van der Hoorn, Natalie R Boonzaier, Tomasz Matys, Stephen J Price
Jul 02, 2020
The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its progression...
Adult Aged Aminolevulinic Acid Brain Neoplasms Cohort Studies Contrast Media Diffusion Magnetic Resonance Imaging Disease Progression Female Glioblastoma Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Neural Networks Computer Optical Imaging Retrospective Studies
Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin.
BACKGROUND: Acquiring clinically annotated, spatially stratified tissue samples from human glioblastoma (GBM) is compromised by haemorrhage, brain shift and subjective identification of 'normal' brain. We tested the use of...
Local alkylating chemotherapy applied immediately after 5-ALA guided resection of glioblastoma does not provide additional benefit.
William Sage, Mathew Guilfoyle, Catriona Luney, Adam Young, Rohitashwa Sinha, Donatella Sgubin, Joseph H McAbee, Ruichong Ma, Sarah Jefferies, Rajesh Jena, Fiona Harris, Kieren Allinson, Tomasz Matys, Wendi Qian, Thomas Santarius, Stephen Price, Colin Watts
May 25, 2018
Grade IV glioma is the most common and aggressive primary brain tumour. Gross total resection with 5-aminolevulinic acid (5-ALA) guided surgery combined with local chemotherapy (carmustine wafers) is an attractive treatment...
Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas
Georgios Solomou, Aref-Ali Gharooni, Waqqas Patel, Conor S Gillespie, Melissa Gough, Ashwin Venkatesh, Michael TC Poon, Victoria Wykes, Stephen John Price, Michael D Jenkinson, Colin Watts, Puneet Plaha
Jul 27, 2022
INTRODUCTION: 5-aminolevulinic acid (5-ALA) is a proagent developed for fluorescent-guided surgery for high-grade glioma patients associated with a significant increase in resection conferring survival. 5-ALA was shown to...
FUTURE-GB
Puneet Plaha, Sophie Camp, Jonathan Cook, Peter McCulloch, Natalie Voets, Ruichong Ma, Martin JB Taphoorn, Linda Dirven, Matthew Grech-Sollars, Colin Watts, Helen Bulbeck, Michael D Jenkinson, Matthew Williams, Adrian Lim, Luke Dixon, Stephen John Price, Keyoumars Ashkan, Vasileios Apostolopoulos, Vicki S Barber, Amy Taylor, FUTURE-GB collaborators, Dipankar Nandi
Dec 16, 2022
INTRODUCTION: Surgery remains the mainstay for treatment of primary glioblastoma, followed by radiotherapy and chemotherapy. Current standard of care during surgery involves the intraoperative use of image-guidance and...
Peptide-targeted dendrimeric prodrugs of 5-aminolevulinic acid
Photodynamic therapy (PDT) is a promising approach for the targeted treatment of cancer and various other human disorders. An effective, clinically approved approach in PDT involves the administration of 5-aminolevulinic acid...
Aminolevulinic Acid click chemistry Fluorescence diagnosis Peptide Photodynamic therapy prodrug protoporphyrin IX /dk/atira/pure/subjectarea/asjc/1300/1303 name=Biochemistry /dk/atira/pure/subjectarea/asjc/1300/1312 name=Molecular Biology /dk/atira/pure/subjectarea/asjc/3000/3002 name=Drug Discovery /dk/atira/pure/subjectarea/asjc/1600/1605 name=Organic Chemistry /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being