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The aberrant aggregation of proteins is a key molecular event in the development and progression of a wide range of neurodegenerative disorders. We have shown previously that squalamine and trodusquemine, two natural products in...

neuroscience protein misfolding diseases Amyloid-β Alzheimer’s disease α-synuclein Parkinson’s disease OLIGOMERS aminosterols small molecule drug discovery

Original Article Alzheimer’s disease Amyloid-β MAPT Tau Isoform Expression Sheep

Alzheimer’s disease Amyloid-β Isoform Expression MAPT Sheep Tau Aged Animals Alzheimer Disease Amyloid beta-Peptides Neurodegenerative Diseases Protein Isoforms Sheep Sheep Domestic tau Proteins

Alzheimer's Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. To investigate the link between...

Alzheimer’s disease Amyloid-β knock-in mouse model Tau Animals Mice Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Brain Disease Models Animal Mice Transgenic Plaque Amyloid tau Proteins

Acrylamide quenching Amyloid fibril Amyloid-β Aβ oligomer tyrosine fluorescence Amino Acid Sequence Amyloid beta-Peptides Dimerization Molecular Probe Techniques Molecular Sequence Data Multiprotein Complexes Peptide Fragments Protein Conformation Solvents Structure-Activity Relationship Tyrosine

3D structure of amyloid aggregates Alzheimer's Disease arctic mutant SIM Amyloid-β amyloid-β (Aβ) microscopic imaging Molecular dynamics neurodegeneration protein aggregation structural model Amyloid beta-Peptides Humans Kinetics Microscopy Confocal Microscopy Fluorescence Models Molecular Mutation Optical Imaging Protein Conformation Protein Multimerization

Aggregation of α-synuclein plays a key role in the development of Parkinson's disease. Soluble aggregates are present not only within human brain but also the CSF and blood. Characterizing the aggregates present in these...

Parkinson’s disease Aggregates Amyloid-β early-disease serum biomarkers Super-resolution imaging α-synuclein aggregates Amyloid beta-Peptides Biomarkers Brain Humans Parkinson Disease Protein Aggregates ALPHA-SYNUCLEIN

Alzheimer’s disease is associated with the aggregation of the amyloid-β peptide (Aβ), resulting in the deposition of amyloid plaques in brain tissue. Recent scrutiny of the mechanisms by which Aβ aggregates induce neuronal...

protein misfolded oligomers structure–toxicity relationship rationally designed antibodies research tools biophysics Amyloid-β Alzheimer’s disease

Alzheimer's disease is associated with the aggregation of the amyloid-β peptide (Aβ), resulting in the deposition of amyloid plaques in brain tissue. Recent scrutiny of the mechanisms by which Aβ aggregates induce neuronal...

Alzheimer’s disease Amyloid-β biophysics protein misfolded oligomers rationally designed antibodies research tools structure–toxicity relationship Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Antibodies Antibody Formation Brain Drug Design Humans Neurons Peptide Fragments Plaque Amyloid Protein Aggregates Protein Engineering Structure-Activity Relationship

Sheep Tau Alzheimer’s disease MAPT Isoform Expression Amyloid-β Animals Sheep Domestic Alzheimer Disease Neurodegenerative Diseases tau Proteins Protein Isoforms Aged Amyloid beta-Peptides

BACKGROUND: What combination of risk factors for Alzheimer's disease (AD) are most predictive of cognitive decline in cognitively unimpaired individuals remains largely unclear. We studied associations between APOE genotype...

APOE genotype Amyloid-β cognitive decline Longitudinal design neuropsychology polygenic risk score Preclinical Alzheimer’s disease Female Humans Male Alzheimer Disease Amyloid beta-Peptides Cognitive Dysfunction Genotype Apolipoproteins E Memory Disorders Risk Factors Positron-Emission Tomography Apolipoprotein E4

Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people and currently lacking available disease-modifying treatments. Appropriate disease models are necessary to investigate disease mechanisms...

Drosophila melanogaster Alzheimer's Disease Amyloid-β endo-lysosomal system neurodegeneration Alzheimer Disease Amyloid Precursor Protein Secretases Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Animals Genetically Modified Brain Disease Models Animal Drosophila Proteins Drosophila melanogaster Humans Neurodegenerative Diseases Oxidative Stress

The aberrant aggregation of proteins is a key molecular event in the development and progression of a wide range of neurodegenerative disorders. We have shown previously that squalamine and trodusquemine, two natural products in...

Alzheimer’s disease Parkinson’s disease aminosterols Amyloid-β OLIGOMERS protein misfolding diseases small molecule drug discovery α-synuclein