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Cardiac arrhythmogenesis
Around 3.7 million individuals worldwide die each year from cardiac arrhythmias; this exceeds the total numbers of deaths from all cancers in the Western world. Despite major progress in interventional including device therapy...
Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts.
SC Salvage, JH King, KH Chandrasekharan, DIG Jafferji, L Guzadhur, HR Matthews, CL-H Huang, JA Fraser
May 29, 2015
CPVT Na+ currents atrial arrhythmia conduction velocity flecainide ryanodine receptor Animals Anti-Arrhythmia Agents Atrial fibrillation Flecainide Ion Channel Gating Membrane Potentials Mice Mutation NAV1.5 Voltage-Gated Sodium Channel Ryanodine Receptor Calcium Release Channel sodium Treatment Outcome Voltage-Gated Sodium Channel Blockers
Update on antiarrhythmic drug pharmacology.
Cardiac arrhythmias constitute a major public health problem. Pharmacological intervention remains mainstay to their clinical management. This, in turn, depends upon systematic drug classification schemes relating their...
Modernized Oxford Classification Vaughan-Williams antiarrhythmic drugs cardiac arrhythmias sicilian gambit Action Potentials Animals Anti-Arrhythmia Agents Arrhythmias Cardiac Heart Conduction System Heart Rate Humans Molecular Targeted Therapy Myocardial Contraction Treatment Outcome Ventricular Function Ventricular Remodeling
Multiple targets for flecainide action
SC Salvage, KH Chandrasekharan, K Jeevaratnam, AF Dulhunty, AJ Thompson, AP Jackson, CL-H Huang
Jun 29, 2017
Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions
Samantha C Salvage, Esther M Gallant, James A Fraser, Christopher L-H Huang, Angela F Dulhunty
Aug 16, 2021
Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial fibrillation. CPVT has been successfully treated with flecainide...
RyR2 RyR2 activation RyR2 inhibition RyR2-P2328S Atrial fibrillation Catecholaminergic polymorphic ventricular tachycardia flecainide Animals Anti-Arrhythmia Agents Arrhythmias Cardiac Calcium flecainide Ion Channel Gating Lipid Bilayers Membrane Potentials Mice Ryanodine Receptor Calcium Release Channel Sarcoplasmic Reticulum Voltage-Gated Sodium Channel Blockers