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In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors.
Jingxu Guo, Alice Douangamath, Weixiao Song, Alun R Coker, AW Edith Chan, Steve P Wood, Jonathan B Cooper, Efrat Resnick, Nir London, Frank von Delft
Sep 25, 2020
Outbreaks of human epidemic nonbacterial gastroenteritis are mainly caused by noroviruses. Viral replication requires a 3C-like cysteine protease (3CLpro) which processes the 200 kDa viral polyprotein into six functional...