Search
Results: 7
Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis.
Gemma D Banham, Colin YC Lee, John R Ferdinand, Rebeccah J Matthews, Chenzhi Jing, Nicholas Smithers, Rab K Prinjha, Menna R Clatworthy
May 24, 2022
IgG antibodies form immune complexes (IC) that propagate inflammation and tissue damage in autoimmune diseases such as systemic lupus erythematosus. IgG IC engage Fcγ receptors (FcγR) on mononuclear phagocytes (MNP), leading to...
A double-edged sword
The past year has demonstrated the power of collaborative scientific effort in rapidly developed vaccines to curb the SARS-CoV-2 pandemic and repurposed drugs to improve patient outcomes in severe COVID-19 disease. The morbidity...
Deciphering the Immune Complexity in Esophageal Adenocarcinoma and Pre-Cancerous Lesions With Sequential Multiplex Immunohistochemistry and Sparse Subspace Clustering Approach.
Srinand Sundaram, Eun Na Kim, Georgina M Jones, Shamilene Sivagnanam, Monika Tripathi, Ahmad Miremadi, Massimiliano di Pietro, Lisa M Coussens, Rebecca C Fitzgerald, Young Hwan Chang, Lizhe Zhuang
Jun 07, 2022
Esophageal adenocarcinoma (EAC) develops from a chronic inflammatory environment across four stages: intestinal metaplasia, known as Barrett's esophagus, low- and high-grade dysplasia, and adenocarcinoma. Although the genomic...
Barrett’s esophagus Esophageal Adenocarcinoma immune complexity multiplex imaging sparse subspace clustering Adenocarcinoma Antigen-Antibody Complex Barrett Esophagus Cluster Analysis Ecosystem Esophageal Neoplasms Forkhead Transcription Factors Humans Immunohistochemistry Metaplasia Tumor Microenvironment
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.
Lisa C Willcocks, Paul A Lyons, Menna R Clatworthy, James I Robinson, Wanling Yang, Stephen A Newland, Vincent Plagnol, Naomi N McGovern, Alison M Condliffe, Edwin R Chilvers, Dwomoa Adu, Elaine C Jolly, Richard Watts, Yu Lung Lau, Ann W Morgan, Gerard Nash, Kenneth GC Smith
Jun 28, 2018
Copy number (CN) variation (CNV) has been shown to be common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low CN of FCGR3B has recently been associated with systemic...