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Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist.
Aimee L Brame, Janet J Maguire, Peiran Yang, Alex Dyson, Rubben Torella, Joseph Cheriyan, Mervyn Singer, Robert C Glen, Ian B Wilkinson, Anthony P Davenport
Apr 29, 2015
[Pyr1]apelin-13 pulmonary arterial hypertension β-arrestin G-protein coupled receptors Animals Antipyretics Apelin Receptors Disease Models Animal GTP-Binding Proteins Humans Hypertension Pulmonary Intercellular Signaling Peptides and Proteins Male Rats Rats Wistar Receptors G-Protein-Coupled Research Design Saphenous Vein Vasodilation