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Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
Eric M Reiman, Joseph F Arboleda-Velasquez, Yakeel T Quiroz, Matthew J Huentelman, Thomas G Beach, Richard J Caselli, Yinghua Chen, Yi Su, Amanda J Myers, John Hardy, Jean Paul Vonsattel, Steven G Younkin, David A Bennett, Philip L De Jager, Eric B Larson, Paul K Crane, C Dirk Keene, M Ilyas Kamboh, Julia K Kofler, Linda Duque, John R Gilbert, Harry E Gwirtsman, Joseph D Buxbaum, Dennis W Dickson, Matthew P Frosch, Bernardino F Ghetti, Kathryn L Lunetta, Li-San Wang, Bradley T Hyman, Walter A Kukull, Tatiana Foroud, Jonathan L Haines, Richard P Mayeux, Margaret A Pericak-Vance, Julie A Schneider, John Q Trojanowski, Lindsay A Farrer, Gerard D Schellenberg, Gary W Beecham, Thomas J Montine, Gyungah R Jun, Alzheimer’s Disease Genetics Consortium
Feb 02, 2021
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known whether...