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Age at Menarche and Blood Pressure in Pregnancy.
Monitoring of Optimal Cerebral Perfusion Pressure in Traumatic Brain Injured Patients Using a Multi-Window Weighting Algorithm.
Xiuyun Liu, Natasha M Maurits, Marcel JH Aries, Marek Czosnyka, Ari Ercole, Joseph Donnelly, Danilo Cardim, Dong-Joo Kim, Celeste Dias, Manuel Cabeleira, Peter Smielewski
Nov 23, 2017
Methods to identify an autoregulation guided "optimal" cerebral perfusion pressure (CPPopt) for traumatic brain injury patients (TBI) have been reported through several studies. An important drawback of existing methodology is...
CPPopt TBI cerebral autoregulation multi-window algorithm pressure reactivity index Adult Algorithms Arterial Pressure Brain Injuries Traumatic Cerebrovascular Circulation Data Interpretation Statistical Female Glasgow Coma Scale Glasgow Outcome Scale Humans Intracranial Pressure Male Middle Aged Neurophysiological Monitoring Outcome Assessment Health Care Reproducibility of Results Retrospective Studies Young Adult
Principles of cerebral hemodynamics when intracranial pressure is raised
Mi Ok Kim, Audrey Adji, Michael F O'Rourke, Alberto P Avolio, Peter Smielewski, John D Pickard, Marek Czosnyka
May 06, 2015
Transfer-function-free technique for the noninvasive determination of the human arterial pressure waveform.
Alessandro Giudici, Carlo Palombo, Carmela Morizzo, Michaela Kozakova, J Kennedy Cruickshank, Ian B Wilkinson, Ashraf W Khir
Sep 23, 2021
Using the relationship between brain tissue regional saturation of oxygen and mean arterial pressure to determine the optimal mean arterial pressure in patients following cardiac arrest
Mypinder S Sekhon, Peter Smielewski, Tahara D Bhate, Penelope M Brasher, Denise Foster, David K Menon, Arun K Gupta, Marek Czosnyka, William R Henderson, Kenneth Gin, Graham Wong, Donald E Griesdale
Mar 19, 2019
INTRODUCTION: Prospectively assess cerebral autoregulation and optimal mean arterial pressure (MAPOPT) using the dynamic relationship between MAP and regional saturation of oxygen (rSO2) using near-infrared spectroscopy....
Simultaneous Transients of Intracranial Pressure and Heart Rate in Traumatic Brain Injury
Giovanna Maria Dimitri, Shruti Agrawal, Adam Young, Joseph Donnelly, Xiuyun Liu, Peter Smielewski, Peter Hutchinson, Marek Czosnyka, Pietro Lio, Christina Haubrich
Aug 02, 2019
OBJECTIVES: The detection of increasing intracranial pressure (ICP) is important in preventing secondary brain injuries. Before mean ICP increases critically, transient ICP elevations may be observed. We have observed ICP...
Relationship Between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute TBI Patients
François Mathieu, Frederick A Zeiler, Daniel P Whitehouse, Tilak Das, Ari Ercole, Peter Smielewski, Peter J Hutchinson, Marek Czosnyka, Virginia FJ Newcombe, David K Menon
Nov 13, 2019
BACKGROUND: Failure of cerebral autoregulation and progression of intracranial lesion have both been shown to contribute to poor outcome in patients with acute traumatic brain injury (TBI), but the interplay between the two...
Neurophysiological Monitoring Traumatic brain injury Traumatic intracranial hemorrhage Adult Arterial Pressure Brain Contusion Brain Edema Brain Injuries Traumatic Cerebrovascular Circulation Disease Progression Female Glasgow Coma Scale Glasgow Outcome Scale Homeostasis Humans Intensive Care Units Intracranial hemorrhage Traumatic Intracranial Pressure Male Middle Aged Retrospective Studies Tomography X-Ray Computed Young Adult
Pressure reactivity index
Autoregulation after traumatic brain injury can be monitored continuously using simple signal processing of intracranial pressure and arterial blood pressure. The pressure reactivity index (PRx) showed several benefits when it...
Increased ICP and Its Cerebral Haemodynamic Sequelae.
Joseph Donnelly, Marek Czosnyka, Spencer Harland, Georgios V Varsos, Danilo Cardim, Chiara Robba, Xiuyun Liu, Philip N Ainslie, Peter Smielewski
May 22, 2018
OBJECTIVES: Increased intracranial pressure (ICP) is a pathological feature of many neurological diseases; however, the local and systemic sequelae of raised ICP are incompletely understood. Using an experimental paradigm, we...
Do ICP-Derived Parameters Differ in Vegetative State from Other Outcome Groups After Traumatic Brain Injury?
Marek Czosnyka, Joseph Donnelly, Leanne Calviello, Peter Smielewski, David K Menon, John D Pickard
Jul 20, 2018
OBJECTIVE: In nearly 1,000 traumatic brain injury (TBI) patients monitored in the years 1992-2014, we identified 18 vegetative state (VS) cases. Our database provided access to continuous computer-recorded signals, which we used...
Brain injury Intracranial Pressure outcome Slow waves Vegetative state Arterial Pressure Brain Injuries Traumatic Case-Control Studies Cerebrovascular Circulation Glasgow Outcome Scale Humans Intracranial Hypertension Intracranial Pressure Outcome Assessment Health Care Persistent Vegetative State Prognosis
Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure
Thomas Weber, Athanase D Protogerou, Mohsen Agharazii, Antonis Argyris, Sola Aoun Bahous, Jose R Banegas, Ronald K Binder, Jacques Blacher, Andréa Araujo Brandao, Juan J Cruz, Kathrin Danninger, Cristina Giannatasio, Auxiliadora Graciani, Bernhard Hametner, Piotr Jankowski, Yan Li, Alessandro Maloberti, Christopher C Mayer, Barry J McDonnell, Carmel M McEniery, Marco Antonio Mota Gomes, Annelise Machado Gomes, Maria Lorenza Muiesan, Janos Nemcsik, Anna Paini, Enrique Rodilla, Aletta E Schutte, Petros P Sfikakis, Dimitrios Terentes-Printzios, Alexandre Vallée, Charalambos Vlachopoulos, Lisa Ware, Ian Wilkinson, Robert Zweiker, James E Sharman, Siegfried Wassertheurer, International Academic 24-Hour Ambulatory Aortic Blood Pressure Consortium (i24abc.org)
Jan 07, 2022
Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared...
Visualisation of the 'Optimal Cerebral Perfusion' Landscape in Severe Traumatic Brain Injury Patients.
Ari Ercole, Peter Smielewski, Marcel JH Aries, Robin Wesselink, Jan Willem J Elting, Joseph Donnelly, Marek Czosnyka, Natasha M Maurits
Dec 04, 2017
OBJECTIVE: An 'optimal' cerebral perfusion pressure (CPPopt) can be defined as the point on the CPP scale corresponding to the greatest autoregulatory capacity. This can be established by examining the pressure reactivity index...
Univariate comparison of performance of different cerebrovascular reactivity indices for outcome association in adult TBI
Frederick A Zeiler, Ari Ercole, Manuel Cabeleira, Tommaso Zoerle, Nino Stocchetti, David K Menon, Peter Smielewski, Marek Czosnyka, CENTER-TBI High Resolution Sub-Study Participants and Investigators
Feb 11, 2019
Approaches to treat pulmonary arterial hypertension by targeting BMPR2
Pulmonary arterial hypertension (PAH) is estimated to affect between 10 and 50 people per million worldwide. The lack of cure and devastating nature of the disease means that treatment is crucial to arrest rapid clinical...
Evaluation of the relationship between slow-waves of intracranial pressure, mean arterial pressure and brain tissue oxygen in TBI
Frederick A Zeiler, Manuel Cabeleira, Peter J Hutchinson, Nino Stocchetti, Marek Czosnyka, Peter Smielewski, Ari Ercole, CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
May 11, 2020
Brain tissue oxygen (PbtO2) monitoring in traumatic brain injury (TBI) has demonstrated strong associations with global outcome. Additionally, PbtO2 signals have been used to derive indices thought to be associated with...
Observations on the Cerebral Effects of Refractory Intracranial Hypertension After Severe Traumatic Brain Injury.
Joseph Donnelly, Peter Smielewski, Hadie Adams, Frederick A Zeiler, Danilo Cardim, Xiuyun Liu, Marta Fedriga, Peter Hutchinson, David K Menon, Marek Czosnyka
Jul 02, 2019
BACKGROUND: Raised intracranial pressure (ICP) is a prominent cause of morbidity and mortality after severe traumatic brain injury (TBI). However, in the clinical setting, little is known about the cerebral physiological...
autoregulation Cerebral hemodynamics Cerebral oxygenation cerebral perfusion pressure Intracranial Hypertension Intracranial Pressure Traumatic brain injury Adolescent Adult Arterial Pressure Brain Brain Injuries Traumatic Cerebrovascular Circulation Decompressive Craniectomy Female Glasgow Coma Scale Homeostasis Humans Intracranial Hypertension Male Mortality Oxygen Retrospective Studies Severity of Illness Index Time Factors Young Adult
Pressure Reactivity-Based Optimal Cerebral Perfusion Pressure in a Traumatic Brain Injury Cohort.
J Donnelly, M Czosnyka, H Adams, C Robba, LA Steiner, D Cardim, B Cabella, X Liu, A Ercole, PJ Hutchinson, DK Menon, MJH Aries, P Smielewski
Mar 16, 2018
OBJECTIVES: Retrospective data from patients with severe traumatic brain injury (TBI) indicate that deviation from the continuously calculated pressure reactivity-based "optimal" cerebral perfusion pressure (CPPopt) is...
autoregulation Cerebral hemodynamics cerebral perfusion pressure Intracranial Pressure Traumatic brain injury Adult Arterial Pressure Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Disease Management Female Glasgow Outcome Scale Humans Intracranial Pressure Male Monitoring Physiologic Retrospective Studies Trauma Severity Indices
The Burden of Brain Hypoxia and Optimal Mean Arterial Pressure in Patients With Hypoxic Ischemic Brain Injury After Cardiac Arrest.
Mypinder S Sekhon, Peter Gooderham, David K Menon, Penelope MA Brasher, Denise Foster, Danilo Cardim, Marek Czosnyka, Peter Smielewski, Arun K Gupta, Philip N Ainslie, Donald EG Griesdale
Apr 03, 2019
OBJECTIVES: In patients at risk of hypoxic ischemic brain injury following cardiac arrest, we sought to: 1) characterize brain oxygenation and determine the prevalence of brain hypoxia, 2) characterize autoregulation using the...
Validation of Pressure Reactivity and Pulse Amplitude Indices against the Lower Limit of Autoregulation, Part I
Frederick A Zeiler, Joseph Donnelly, Leanne Calviello, Jennifer K Lee, Peter Smielewski, Ken Brady, Dong-Joo Kim, Marek Czosnyka
Oct 18, 2018
The purpose of this study was to provide validation of intracranial pressure (ICP) derived continuous indices of cerebrovascular reactivity against the lower limit of autoregulation (LLA). Utilizing an intracranial hypertension...
Relationship between fiducial points on the peripheral and central blood pressure waveforms
Ye Li, Antoine Guilcher, Peter H Charlton, Samuel Vennin, Jordi Alastruey, Phil Chowienczyk
Mar 01, 2021
Central systolic blood pressure (cSBP, the peak of the central waveform) is usually regarded as the determinant of peripheral systolic blood pressure with amplification of peripheral systolic blood pressure (pSBP) measured with...
blood pressure measurement/monitoring central pressure left ventricular contractility peripheral pressure Adult Aged Arterial Pressure arteries Blood Pressure Determination Case-Control Studies Computer Simulation Female Humans Hypertension Male Middle Aged Models Cardiovascular Numerical analysis Computer-Assisted Predictive Value of Tests Systole Time Factors Ventricular Function Left
Wavelet pressure reactivity index
Xiuyun Liu, Marek Czosnyka, Joseph Donnelly, Danilo Cardim, Manuel Cabeleira, Peter J Hutchinson, Xiao Hu, Peter Smielewski, Ken Brady
Nov 21, 2018
KEY POINTS: The brain is vulnerable to damage from too little or too much blood flow. A physiological mechanism termed cerebral autoregulation (CA) exists to maintain stable blood flow even if cerebral perfusion pressure (CPP)...
Anti-decubitus bed mattress may interfere with cerebrovascular pressure reactivity measures due to induced ICP and ABP cyclic peaks.
Tas Jeanette, Borg Melisa, Smielewski Peter, Czosnyka Marek, Beqiri Erta, Ercole Ari, Aries Marcel
Jan 29, 2020
Severe traumatic brain injury (TBI) patients are monitored with continuous arterial blood pressure (ABP) and intracranial pressure (ICP). The pressure reactivity index (PRx) is a frequently used correlation coefficient between...
HIF isoforms in the skin differentially regulate systemic arterial pressure.
Andrew S Cowburn, Norihiko Takeda, Adam T Boutin, Jung-Whan Kim, Jane C Sterling, Manando Nakasaki, Mark Southwood, Ananda W Goldrath, Colin Jamora, Victor Nizet, Edwin R Chilvers, Randall S Johnson
Jun 19, 2018
Vascular flow through tissues is regulated via a number of homeostatic mechanisms. Localized control of tissue blood flow, or autoregulation, is a key factor in regulating tissue perfusion and oxygenation. We show here that the...
HIF-alpha Arginase vascular tone Adult Aged Animals Arginase Arterial Pressure Basic Helix-Loop-Helix Transcription Factors Blotting Western Female Humans Hypertension Hypoxia-Inducible Factor 1 alpha Subunit Immunohistochemistry Keratinocytes Male Mice Mice Inbred C57BL Mice Knockout Middle Aged Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Regional Blood Flow Reverse Transcriptase Polymerase Chain Reaction Skin Young Adult
Relationship Between Brain Pulsatility and Cerebral Perfusion Pressure
Leanne A Calviello, Nicolás de Riva, Joseph Donnelly, Marek Czosnyka, Peter Smielewski, David K Menon, Frederick A Zeiler
Aug 08, 2017
BACKGROUND: Determination of relationships between transcranial Doppler (TCD)-based spectral pulsatility index (sPI) and pulse amplitude (AMP) of intracranial pressure (ICP) in 2 groups of severe traumatic brain injury (TBI)...
cerebral perfusion pressure Intracranial Pressure Neurocritical care Pulsatility index Transcranial Doppler Traumatic brain injury Adolescent Adult Aged Arterial Pressure Brain Injuries Traumatic Cerebrovascular Circulation Critical Care Female Humans Intracranial Pressure Male Middle Aged Neurophysiological Monitoring Pulsatile Flow Retrospective Studies Ultrasonography Doppler Transcranial Young Adult
The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness.
Kaisa M Mäki-Petäjä, Sharon ML Barrett, Sarah V Evans, Joseph Cheriyan, Carmel M McEniery, Ian B Wilkinson
Oct 14, 2016
aortic stiffness Autonomic Nervous System blood pressure Healthy Volunteers Heart Rate Hemodynamics Adult Arterial Pressure Autonomic Nervous System Cross-Over Studies Cross-Sectional Studies Double-Blind Method Female Hand Strength Healthy Volunteers Heart Rate Hemodynamics Humans Hypertension Male Pentolinium Tartrate Prognosis Pulse Wave Analysis Role Vascular Stiffness Young Adult
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