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Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures.
Caroline A Oedekoven, Miriam Belmonte, Daniel Bode, Fiona K Hamey, Mairi S Shepherd, James Lok Chi Che, Grace Boyd, Craig McDonald, Serena Belluschi, Evangelia Diamanti, Hugo P Bastos, Katherine S Bridge, Berthold Göttgens, Elisa Laurenti, David G Kent
Apr 12, 2021
Advances in the isolation and gene expression profiling of single hematopoietic stem cells (HSCs) have permitted in-depth resolution of their molecular program. However, long-term HSCs can only be isolated to near purity from...
Cell Cycle Hematopoietic Stem Cells quiescence single-cell RNA sequencing single-cell assays Stem Cell Niche Transplantation Animals Arylsulfotransferase Bone Marrow Transplantation Cell Culture Techniques Cell Cycle Cell Differentiation Cells Cultured Cytokines Hematopoietic Stem Cells Hibernation Mice Mice Inbred C57BL Multiprotein Complexes Signaling Lymphocytic Activation Molecule Family Member 1 Single-Cell Analysis Stem Cell Niche Suppressor of Cytokine Signaling Proteins Transcription Factor AP-1 Transcriptome