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Results: 81
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, Blue Mountains Eye Study—GWAS group, Pieter Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Emmanuelle Souzeau, Sandra E Staffieri, Jost B Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H Kang, Sionne EM Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, NEIGHBORHOOD Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline CW Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart MacGregor
Sep 05, 2018
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In...
ADAMTS Proteins Asian People Cornea Corneal Diseases Corneal Dystrophies Hereditary Decorin Ehlers-Danlos Syndrome Eye Diseases Hereditary Fibrillin-1 Gene Expression Genome Human Genome-Wide Association Study Glaucoma Open-Angle Humans Keratoconus Loeys-Dietz Syndrome Lumican Marfan Syndrome Mendelian Randomization Analysis Myopia Polymorphism Single Nucleotide Proteoglycans Quantitative Trait Loci Quantitative Trait Heritable Transforming Growth Factor beta2 White People
Differences in objectively measured physical activity and sedentary behaviour between white Europeans and south Asians recruited from primary care
Gregory JH Biddle, Charlotte L Edwardson, Alex V Rowlands, Melanie J Davies, Danielle H Bodicoat, Wendy Hardeman, Helen Eborall, Stephen Sutton, Simon Griffin, Kamlesh Khunti, Thomas Yates
Feb 07, 2019
Validation of the Empathy Quotient in Mainland China.
Q Zhao, DL Neumann, X Cao, S Baron-Cohen, X Sun, Y Cao, C Yan, Y Wang, L Shao, DHK Shum
Aug 04, 2017
Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies.
Preterm birth race Racial group Small for gestational age Spontaneous abortion Abortion Spontaneous Adult Age Factors Asian People Black People Body Mass Index Caribbean Region Female Humans Incidence Infant Small for Gestational Age London obesity Pregnancy premature birth Retrospective Studies Risk Factors White People Young Adult
Serum metabolomics profiles in response to n-3 fatty acids in Chinese patients with type 2 diabetes
Ju-Sheng Zheng, Mei Lin, Fumiaki Imamura, Wenwen Cai, Ling Wang, Jue-Ping Feng, Yue Ruan, Jun Tang, Fenglei Wang, Hong Yang, Duo Li
Jul 26, 2016
Distribution and association of interpregnancy weight change with subsequent pregnancy outcomes in Asian women.
Chee Wai Ku, Tuck Seng Cheng, Chee Onn Ku, Kathy Xinzhuo Zhou, Yin Bun Cheung, Keith M Godfrey, Wee Meng Han, Fabian Yap, Jerry Kok Yen Chan, See Ling Loy
Mar 24, 2023
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences.
Jia-Wern Pan, Muhammad Mamduh Ahmad Zabidi, Pei-Sze Ng, Mei-Yee Meng, Siti Norhidayu Hasan, Bethan Sandey, Stephen-John Sammut, Cheng-Har Yip, Pathmanathan Rajadurai, Oscar M Rueda, Carlos Caldas, Suet-Feung Chin, Soo-Hwang Teo
Nov 02, 2020
Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations.
Takashi Gakuhari, Shigeki Nakagome, Simon Rasmussen, Morten E Allentoft, Takehiro Sato, Thorfinn Korneliussen, Blánaid Ní Chuinneagáin, Hiromi Matsumae, Kae Koganebuchi, Ryan Schmidt, Souichiro Mizushima, Osamu Kondo, Nobuo Shigehara, Minoru Yoneda, Ryosuke Kimura, Hajime Ishida, Tadayuki Masuyama, Yasuhiro Yamada, Atsushi Tajima, Hiroki Shibata, Atsushi Toyoda, Toshiyuki Tsurumoto, Tetsuaki Wakebe, Hiromi Shitara, Tsunehiko Hanihara, Eske Willerslev, Martin Sikora, Hiroki Oota
Oct 12, 2020
Anatomically modern humans reached East Asia more than 40,000 years ago. However, key questions still remain unanswered with regard to the route(s) and the number of wave(s) in the dispersal into East Eurasia. Ancient genomes at...
Association of alcohol consumption with prevalence of fatty liver after adjustment for dietary patterns
Ryoko Tajima, Fumiaki Imamura, Takeshi Kimura, Satomi Kobayashi, Katsunori Masuda, Kaoruko Iida
Jul 24, 2019
Effects of n-3 fatty acid supplements on glycemic traits in Chinese type 2 diabetic patients
Ju-Sheng Zheng, Mei Lin, Ling Fang, Ying Yu, Liping Yuan, Yongxin Jin, Jueping Feng, Ling Wang, Hong Yang, Weiyu Chen, Dandan Li, Jun Tang, Wenwen Cai, Meiqi Shi, Zihao Li, Fenglei Wang, Duo Li
Jul 04, 2016
Randomized controlled trial Type 2 diabetes n-3 Fatty acids Aged Asian People Cholesterol LDL Corn Oil Diabetes mellitus Type 2 Dietary Supplements Docosahexaenoic Acids Double-Blind Method Eicosapentaenoic Acid Fatty Acids Omega-3 Female Fish Oils Glycated Hemoglobin Humans Linseed Oil Male Middle Aged
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
W Zhao, A Rasheed, E Tikkanen, J-J Lee, AS Butterworth, JMM Howson, TL Assimes, R Chowdhury, M Orho-Melander, S Damrauer, A Small, S Asma, M Imamura, T Yamauch, JC Chambers, P Chen, BR Sapkota, N Shah, S Jabeen, P Surendran, Y Lu, W Zhang, A Imran, S Abbas, F Majeed, K Trindade, N Qamar, NH Mallick, Z Yaqoob, T Saghir, SNH Rizvi, A Memon, SZ Rasheed, F-U-R Memon, K Mehmood, N Ahmed, IH Qureshi, Tanveer-Us-Salam, W Iqbal, U Malik, N Mehra, JZ Kuo, WH-H Sheu, X Guo, CA Hsiung, J-MJ Juang, KD Taylor, Y-J Hung, W-J Lee, T Quertermous, I-T Lee, C-C Hsu, EP Bottinger, S Ralhan, YY Teo, T-D Wang, DS Alam, E Di Angelantonio, S Epstein, SF Nielsen, BG Nordestgaard, A Tybjaerg-Hansen, R Young, CHD Exome+ Consortium, M Benn, R Frikke-Schmidt, PR Kamstrup, EPIC-CVD Consortium, EPIC-InterAct Consortium, Michigan Biobank, JW Jukema, N Sattar, R Smit, R-H Chung, K-W Liang, S Anand, DK Sanghera, S Ripatti, RJF Loos, JS Kooner, ES Tai, JI Rotter, Y-DI Chen, P Frossard, S Maeda, T Kadowaki, M Reilly, G Pare, O Melander, V Salomaa, DJ Rader, J Danesh, BF Voight, D Saleheen
Nov 21, 2017
Asia Asian People Biomarkers Comorbidity Coronary Disease Diabetes mellitus Type 2 Europe Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study HLA-DRB5 Chains Humans Metabolic Networks and Pathways Metabolic Syndrome Molecular Targeted Therapy Mutation Missense Polymorphism Single Nucleotide Risk Factors White People
Patient experience of access to primary care
Adolescent Adult Appointments and Schedules Asian People Attitude to Health England Family Practice Female Health Care Surveys Health Services Accessibility Humans Logistic Models London Male Middle Aged Office Visits patient satisfaction Primary Health Care Probability State Medicine Surveys and Questionnaires White People
Rationale and design of the ADDITION-Leicester study, a systematic screening programme and randomised controlled trial of multi-factorial cardiovascular risk intervention in people with type 2 diabetes mellitus detected by screening.
DR Webb, K Khunti, B Srinivasan, LJ Gray, N Taub, S Campbell, J Barnett, J Henson, S Hiles, A Farooqi, SJ Griffin, NJ Wareham, MJ Davies
Jun 16, 2011
Adult Aged Asia Asian People Cardiovascular Diseases Community Health Services Cost-Benefit Analysis Diabetes mellitus Type 2 Early Diagnosis England Female Glucose Tolerance Test Humans Male Mass Screening Middle Aged Predictive Value of Tests Prospective Studies Research Design Risk Assessment Risk Factors Single-Blind Method Treatment Outcome
The first horse herders and the impact of early Bronze Age steppe expansions into Asia.
Peter de Barros Damgaard, Rui Martiniano, Jack Kamm, J Víctor Moreno-Mayar, Guus Kroonen, Michaël Peyrot, Gojko Barjamovic, Simon Rasmussen, Claus Zacho, Nurbol Baimukhanov, Victor Zaibert, Victor Merz, Arjun Biddanda, Ilja Merz, Valeriy Loman, Valeriy Evdokimov, Emma Usmanova, Brian Hemphill, Andaine Seguin-Orlando, Fulya Eylem Yediay, Inam Ullah, Karl-Göran Sjögren, Katrine Højholt Iversen, Jeremy Choin, Constanza de la Fuente, Melissa Ilardo, Hannes Schroeder, Vyacheslav Moiseyev, Andrey Gromov, Andrei Polyakov, Sachihiro Omura, Süleyman Yücel Senyurt, Habib Ahmad, Catriona McKenzie, Ashot Margaryan, Abdul Hameed, Abdul Samad, Nazish Gul, Muhammad Hassan Khokhar, OI Goriunova, Vladimir I Bazaliiskii, John Novembre, Andrzej W Weber, Ludovic Orlando, Morten E Allentoft, Rasmus Nielsen, Kristian Kristiansen, Martin Sikora, Alan K Outram, Richard Durbin, Eske Willerslev
Oct 30, 2020
The Yamnaya expansions from the western steppe into Europe and Asia during the Early Bronze Age (~3000 BCE) are believed to have brought with them Indo-European languages and possibly horse husbandry. We analyzed 74 ancient...
The Chinese version of obsessive compulsive drug use scale
Hengfen Gong, Yingying Zhang, Qihuan Ren, Zhirong Zhou, Huijing Zhou, Xirong Sun, Chencheng Zhang, Valerie Voon, Min Zhao, Shunying Yu
Nov 24, 2020
BACKGROUND: The Obsessive Compulsive Drug Use Scale (OCDUS) measures the overall craving level within a period from a multidimensional perspective. However, no studies have addressed the validity of the new OCDUS factor...
Regional TMPRSS2 V197M Allele Frequencies Are Correlated with COVID-19 Case Fatality Rates.
Sungwon Jeon, Asta Blazyte, Changhan Yoon, Hyojung Ryu, Yeonsu Jeon, Youngjune Bhak, Dan Bolser, Andrea Manica, Eun-Seok Shin, Yun Sung Cho, Byung Chul Kim, Namhee Ryoo, Hansol Choi, Jong Bhak
Nov 09, 2021
Coronavirus disease, COVID-19 (coronavirus disease 2019), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has a higher case fatality rate in European countries than in others, especially East Asian ones....
Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models
Peh Joo Ho, Weang Kee Ho, Alexis J Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M Dunning, Manjeet K Bolla, Antonis C Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
May 27, 2022
BACKGROUND: Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. METHODS...
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals.
Qin Qin Huang, Neneh Sallah, Diana Dunca, Bhavi Trivedi, Karen A Hunt, Sam Hodgson, Samuel A Lambert, Elena Arciero, John Wright, Chris Griffiths, Richard C Trembath, Harry Hemingway, Michael Inouye, Sarah Finer, David A van Heel, R Thomas Lumbers, Hilary C Martin, Karoline Kuchenbaecker
Sep 09, 2022
Individuals with South Asian ancestry have a higher risk of heart disease than other groups but have been largely excluded from genetic research. Using data from 22,000 British Pakistani and Bangladeshi individuals with linked...
Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.
Xiang Shu, Jirong Long, Qiuyin Cai, Sun-Seog Kweon, Ji-Yeob Choi, Michiaki Kubo, Sue K Park, Manjeet K Bolla, Joe Dennis, Qin Wang, Yaohua Yang, Jiajun Shi, Xingyi Guo, Bingshan Li, Ran Tao, Kristan J Aronson, Kelvin YK Chan, Tsun L Chan, Yu-Tang Gao, Mikael Hartman, Weang Kee Ho, Hidemi Ito, Motoki Iwasaki, Hiroji Iwata, Esther M John, Yoshio Kasuga, Ui Soon Khoo, Mi-Kyung Kim, Sun-Young Kong, Allison W Kurian, Ava Kwong, Eun-Sook Lee, Jingmei Li, Artitaya Lophatananon, Siew-Kee Low, Shivaani Mariapun, Koichi Matsuda, Keitaro Matsuo, Kenneth Muir, Dong-Young Noh, Boyoung Park, Min-Ho Park, Chen-Yang Shen, Min-Ho Shin, John J Spinelli, Atsushi Takahashi, Chiuchen Tseng, Shoichiro Tsugane, Anna H Wu, Yong-Bing Xiang, Taiki Yamaji, Ying Zheng, Roger L Milne, Alison M Dunning, Paul DP Pharoah, Montserrat García-Closas, Soo-Hwang Teo, Xiao-Ou Shu, Daehee Kang, Douglas F Easton, Jacques Simard, Wei Zheng
Mar 12, 2020
Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from...
Ancient origins of low lean mass among South Asians and implications for modern type 2 diabetes susceptibility.
Elucidating the genetic architecture of reproductive ageing in the Japanese population.
Momoko Horikoshi, Felix R Day, Masato Akiyama, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Kazuyoshi Ishigaki, Masahiro Kanai, Hollis Wright, Carlos A Toro, Sergio R Ojeda, Alejandro Lomniczi, Michiaki Kubo, Ken K Ong, John RB Perry
Aug 16, 2018
Population studies elucidating the genetic architecture of reproductive ageing have been largely limited to European ancestries, restricting the generalizability of the findings and overlooking possible key genes poorly captured...
The Bangladesh Risk of Acute Vascular Events (BRAVE) Study
Rajiv Chowdhury, Dewan S Alam, Ismail Ibrahim Fakir, Sheikh Daud Adnan, Aliya Naheed, Ishrat Tasmin, Md Mostafa Monower, Farzana Hossain, Fatema Mahjabin Hossain, Md Mostafizur Rahman, Sadia Afrin, Anjan Kumar Roy, Minara Akter, Sima Akter Sume, Ajoy Kumer Biswas, Lisa Pennells, Praveen Surendran, Robin D Young, Sarah A Spackman, Khaled Hasan, Eric Harshfield, Nasir Sheikh, Richard Houghton, Danish Saleheen, Joanna MM Howson, Adam S Butterworth, Cardiology Research Group, Rubhana Raqib, Abdulla Al Shafi Majumder, John Danesh, Emanuele Di Angelantonio
Jun 05, 2015
Language spoken at home and the association between ethnicity and doctor-patient communication in primary care
MEDICAL EDUCATION & TRAINING PRIMARY CARE Adult Asian People communication Communication Barriers Cross-Sectional Studies Ethnicity Female Health Care Surveys Humans language Male Physician-Patient Relations Primary Health Care Quality of Health Care Surveys and Questionnaires United Kingdom White People
Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry.
Zhaohui Du, Guimin Gao, Babatunde Adedokun, Thomas Ahearn, Kathryn L Lunetta, Gary Zirpoli, Melissa A Troester, Edward A Ruiz-Narváez, Stephen A Haddad, Parichoy PalChoudhury, Jonine Figueroa, Esther M John, Leslie Bernstein, Wei Zheng, Jennifer J Hu, Regina G Ziegler, Sarah Nyante, Elisa V Bandera, Sue A Ingles, Nicholas Mancuso, Michael F Press, Sandra L Deming, Jorge L Rodriguez-Gil, Song Yao, Temidayo O Ogundiran, Oladosu Ojengbe, Manjeet K Bolla, Joe Dennis, Alison M Dunning, Douglas F Easton, Kyriaki Michailidou, Paul DP Pharoah, Dale P Sandler, Jack A Taylor, Qin Wang, Clarice R Weinberg, Cari M Kitahara, William Blot, Katherine L Nathanson, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Lara E Sucheston-Campbell, Jeannette T Bensen, Stephen J Chanock, Andrew F Olshan, Christine B Ambrosone, Olufunmilayo I Olopade, Joel Yarney, Baffour Awuah, Beatrice Wiafe-Addai, David V Conti, GBHS Study Team, Julie R Palmer, Montserrat Garcia-Closas, Dezheng Huo, Christopher A Haiman
May 11, 2021
BACKGROUND: Polygenic risk scores (PRSs) have been demonstrated to identify women of European, Asian, and Latino ancestry at elevated risk of developing breast cancer (BC). We evaluated the performance of existing PRSs trained...
The transferability of lipid loci across African, Asian and European cohorts.
Karoline Kuchenbaecker, Nikita Telkar, Theresa Reiker, Robin G Walters, Kuang Lin, Anders Eriksson, Deepti Gurdasani, Arthur Gilly, Lorraine Southam, Emmanouil Tsafantakis, Maria Karaleftheri, Janet Seeley, Anatoli Kamali, Gershim Asiki, Iona Y Millwood, Michael Holmes, Huaidong Du, Yu Guo, Meena Kumari, George Dedoussis, Liming Li, Zhengming Chen, Manjinder S Sandhu, Eleftheria Zeggini, Understanding Society Scientific Group
Oct 29, 2019
Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations...
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