Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape.
Abimbola O Kolawole,
Carmen Mirabelli,
David R Hill,
Sophia A Svoboda,
Andrew B Janowski,
Karla D Passalacqua,
Benancio N Rodriguez,
Michael K Dame,
Pamela Freiden,
Ryan P Berger,
Diem-Lan Vu,
Myra Hosmillo,
Mary XD O'Riordan,
Stacey Schultz-Cherry,
Susana Guix,
Jason R Spence,
David Wang,
Christiane E Wobus
Jan 13, 2020
Human astroviruses (HAstV) are understudied positive-strand RNA viruses that cause gastroenteritis mostly in children and the elderly. Three clades of astroviruses, classic, MLB-type and VA-type have been reported in humans. One...